Gluten-free Diet Reduces the Risk of Irritable Bowel Syndrome: A Mendelian Randomization Analysis

Background: Whether a gluten-free diet (GFD) is a cause of irritable bowel syndrome (IBS) remains controversial. We aim at exploring the causal relationship between gluten intake and IBS within Mendelian randomization (MR) design.Methods: We conducted a two-sample MR and selected single-nucleotide p...

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Autores principales:	Yuhao Sun, Xuejie Chen, Shuyang Wang, Minzi Deng, Ying Xie, Xiaoyan Wang, Jie Chen, Therese Hesketh
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	irritable bowel syndrome gluten-free diet mendelian randomization causal association genome-wide association studies Genetics QH426-470
Acceso en línea:	https://doaj.org/article/c2838fa265c649cb96167585263cddd5
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spelling	oai:doaj.org-article:c2838fa265c649cb96167585263cddd52021-11-09T05:11:56ZGluten-free Diet Reduces the Risk of Irritable Bowel Syndrome: A Mendelian Randomization Analysis1664-802110.3389/fgene.2021.684535https://doaj.org/article/c2838fa265c649cb96167585263cddd52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.684535/fullhttps://doaj.org/toc/1664-8021Background: Whether a gluten-free diet (GFD) is a cause of irritable bowel syndrome (IBS) remains controversial. We aim at exploring the causal relationship between gluten intake and IBS within Mendelian randomization (MR) design.Methods: We conducted a two-sample MR and selected single-nucleotide polymorphisms (SNPs) associated with GFD as instrumental variables (IVs). SNPs and genetic associations with GFD and IBS were obtained from the latest genome-wide association studies (GWAS) in Europeans (GFD: cases: 1,376; controls: 63,573; IBS: cases:1,121; controls: 360,073). We performed inverse variance weighting (IVW) as the primary method with several sensitivity analyses like MR-Egger and MR-PRESSO for quality control. The above analyses were re-run using another large dataset of IBS, as well as changing the p-value threshold when screening IVs, to verify the stability of the results.Results: The final estimate indicated significant causal association [per one copy of effect allele predicted log odds ratio (OR) change in GFD intake: OR = 0.97, 95% confidence interval (CI) 0.96 to 0.99, p < 0.01] without heterogeneity statistically (Q = 2.48, p = 0.78) nor horizontal pleiotropy biasing the causality (p = 0.92). Consistent results were found in validation analyses. Results of MR Steiger directionality test indicated the accuracy of our estimate of the causal direction (Steiger p < 0.001).Conclusion: GFD might be a protective factor of IBS. Therefore, we suggest taking a diet of lower gluten intake into account in IBS prevention and clinical practice.Yuhao SunXuejie ChenShuyang WangMinzi DengYing XieXiaoyan WangJie ChenJie ChenTherese HeskethTherese HeskethFrontiers Media S.A.articleirritable bowel syndromegluten-free dietmendelian randomizationcausal associationgenome-wide association studiesGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	irritable bowel syndrome gluten-free diet mendelian randomization causal association genome-wide association studies Genetics QH426-470
spellingShingle	irritable bowel syndrome gluten-free diet mendelian randomization causal association genome-wide association studies Genetics QH426-470 Yuhao Sun Xuejie Chen Shuyang Wang Minzi Deng Ying Xie Xiaoyan Wang Jie Chen Jie Chen Therese Hesketh Therese Hesketh Gluten-free Diet Reduces the Risk of Irritable Bowel Syndrome: A Mendelian Randomization Analysis
description	Background: Whether a gluten-free diet (GFD) is a cause of irritable bowel syndrome (IBS) remains controversial. We aim at exploring the causal relationship between gluten intake and IBS within Mendelian randomization (MR) design.Methods: We conducted a two-sample MR and selected single-nucleotide polymorphisms (SNPs) associated with GFD as instrumental variables (IVs). SNPs and genetic associations with GFD and IBS were obtained from the latest genome-wide association studies (GWAS) in Europeans (GFD: cases: 1,376; controls: 63,573; IBS: cases:1,121; controls: 360,073). We performed inverse variance weighting (IVW) as the primary method with several sensitivity analyses like MR-Egger and MR-PRESSO for quality control. The above analyses were re-run using another large dataset of IBS, as well as changing the p-value threshold when screening IVs, to verify the stability of the results.Results: The final estimate indicated significant causal association [per one copy of effect allele predicted log odds ratio (OR) change in GFD intake: OR = 0.97, 95% confidence interval (CI) 0.96 to 0.99, p < 0.01] without heterogeneity statistically (Q = 2.48, p = 0.78) nor horizontal pleiotropy biasing the causality (p = 0.92). Consistent results were found in validation analyses. Results of MR Steiger directionality test indicated the accuracy of our estimate of the causal direction (Steiger p < 0.001).Conclusion: GFD might be a protective factor of IBS. Therefore, we suggest taking a diet of lower gluten intake into account in IBS prevention and clinical practice.
format	article
author	Yuhao Sun Xuejie Chen Shuyang Wang Minzi Deng Ying Xie Xiaoyan Wang Jie Chen Jie Chen Therese Hesketh Therese Hesketh
author_facet	Yuhao Sun Xuejie Chen Shuyang Wang Minzi Deng Ying Xie Xiaoyan Wang Jie Chen Jie Chen Therese Hesketh Therese Hesketh
author_sort	Yuhao Sun
title	Gluten-free Diet Reduces the Risk of Irritable Bowel Syndrome: A Mendelian Randomization Analysis
title_short	Gluten-free Diet Reduces the Risk of Irritable Bowel Syndrome: A Mendelian Randomization Analysis
title_full	Gluten-free Diet Reduces the Risk of Irritable Bowel Syndrome: A Mendelian Randomization Analysis
title_fullStr	Gluten-free Diet Reduces the Risk of Irritable Bowel Syndrome: A Mendelian Randomization Analysis
title_full_unstemmed	Gluten-free Diet Reduces the Risk of Irritable Bowel Syndrome: A Mendelian Randomization Analysis
title_sort	gluten-free diet reduces the risk of irritable bowel syndrome: a mendelian randomization analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c2838fa265c649cb96167585263cddd5
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Gluten-free Diet Reduces the Risk of Irritable Bowel Syndrome: A Mendelian Randomization Analysis

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