A novel Bayesian seamless phase I/II design.

This paper proposes a novel bayesian phase I/II design featuring using a hybrid mTPI method in phase I for targeting the MTD level and a randomization allocation schema for adaptively assigning patients to desirable doses in phase II. The mechanism of simultaneously escalating dose in phase I and ex...

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Autores principales:	Haitao Pan, Ping Huang, Zuoren Wang, Ling Wang, Chanjuan Li, Jielai Xia
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c28b4f8fc7bf4b3081b4aec5fe47035a
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spelling	oai:doaj.org-article:c28b4f8fc7bf4b3081b4aec5fe47035a2021-11-18T08:56:59ZA novel Bayesian seamless phase I/II design.1932-620310.1371/journal.pone.0073060https://doaj.org/article/c28b4f8fc7bf4b3081b4aec5fe47035a2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023809/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203This paper proposes a novel bayesian phase I/II design featuring using a hybrid mTPI method in phase I for targeting the MTD level and a randomization allocation schema for adaptively assigning patients to desirable doses in phase II. The mechanism of simultaneously escalating dose in phase I and expanding promising doses to phase II is inherited from a design proposed in literature. Extensive simulation studies indicate that our proposed design can vastly save sample size and efficiently assign more patients to optimal dose when compared to two competing designs.Haitao PanPing HuangZuoren WangLing WangChanjuan LiJielai XiaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e73060 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Haitao Pan Ping Huang Zuoren Wang Ling Wang Chanjuan Li Jielai Xia A novel Bayesian seamless phase I/II design.
description	This paper proposes a novel bayesian phase I/II design featuring using a hybrid mTPI method in phase I for targeting the MTD level and a randomization allocation schema for adaptively assigning patients to desirable doses in phase II. The mechanism of simultaneously escalating dose in phase I and expanding promising doses to phase II is inherited from a design proposed in literature. Extensive simulation studies indicate that our proposed design can vastly save sample size and efficiently assign more patients to optimal dose when compared to two competing designs.
format	article
author	Haitao Pan Ping Huang Zuoren Wang Ling Wang Chanjuan Li Jielai Xia
author_facet	Haitao Pan Ping Huang Zuoren Wang Ling Wang Chanjuan Li Jielai Xia
author_sort	Haitao Pan
title	A novel Bayesian seamless phase I/II design.
title_short	A novel Bayesian seamless phase I/II design.
title_full	A novel Bayesian seamless phase I/II design.
title_fullStr	A novel Bayesian seamless phase I/II design.
title_full_unstemmed	A novel Bayesian seamless phase I/II design.
title_sort	novel bayesian seamless phase i/ii design.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/c28b4f8fc7bf4b3081b4aec5fe47035a
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A novel Bayesian seamless phase I/II design.

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