A novel Bayesian seamless phase I/II design.
This paper proposes a novel bayesian phase I/II design featuring using a hybrid mTPI method in phase I for targeting the MTD level and a randomization allocation schema for adaptively assigning patients to desirable doses in phase II. The mechanism of simultaneously escalating dose in phase I and ex...
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Auteurs principaux: | Haitao Pan, Ping Huang, Zuoren Wang, Ling Wang, Chanjuan Li, Jielai Xia |
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Format: | article |
Langue: | EN |
Publié: |
Public Library of Science (PLoS)
2013
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Accès en ligne: | https://doaj.org/article/c28b4f8fc7bf4b3081b4aec5fe47035a |
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