The association between neovascular age-related macular degeneration and regulatory T cells in peripheral blood

Christopher Fugl Madelung,1,2 Mads Krüger Falk,1,2 Torben Lykke Sørensen1,2 1Clinical Eye Research Unit, Department of Ophthalmology, Copenhagen University Hospital, Roskilde, Denmark; 2University of Copenhagen, Copenhagen, Denmark Purpose: To investigate regulatory T...

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Autores principales:	Madelung CF, Falk MK, Sørensen TL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/c28b6f8fbf414f17b7730e355a12836a
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spelling	oai:doaj.org-article:c28b6f8fbf414f17b7730e355a12836a2021-12-02T01:08:06ZThe association between neovascular age-related macular degeneration and regulatory T cells in peripheral blood1177-5483https://doaj.org/article/c28b6f8fbf414f17b7730e355a12836a2015-06-01T00:00:00Zhttp://www.dovepress.com/the-association-between-neovascular-age-related-macular-degeneration-a-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Christopher Fugl Madelung,1,2 Mads Krüger Falk,1,2 Torben Lykke Sørensen1,2 1Clinical Eye Research Unit, Department of Ophthalmology, Copenhagen University Hospital, Roskilde, Denmark; 2University of Copenhagen, Copenhagen, Denmark Purpose: To investigate regulatory T cells (Tregs) and subsets of the Treg population in patients with neovascular age-related macular degeneration (AMD).Patients and methods: Twenty-one neovascular AMD cases and 12 age-matched controls without retinal pathology were selected. Patients were recruited from our outpatient retinal clinic. Control individuals were typically spouses. The diagnosis of neovascular AMD was confirmed using fluorescein and indocyaningreen angiography. Fresh venous blood was analyzed by flow cytometry using fluorochrome-conjugated antibodies to the Treg surface antigens CD4, CD25, CD127, CD45RA, and CD31. Main outcome measures were the percentage of CD25highCD127low Tregs, the percentage of CD45RA+ naïve Tregs, and the percentage of CD31+ recent thymic emigrant Tregs.Results: Comparing patients with neovascular AMD to controls, no significant differences were found in the percentages of CD4+ lymphocytes, CD25highCD127low Tregs, CD45RA+ naïve Tregs, or CD31+ recent thymic emigrant Tregs.Conclusion: Our data does not indicate an altered state of systemic Treg cells in neovascular AMD. Keywords: Tregs, macular degeneration, immunosenescence, CD45RA antigens, CD31 antigensMadelung CFFalk MKSørensen TLDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 1147-1154 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Madelung CF Falk MK Sørensen TL The association between neovascular age-related macular degeneration and regulatory T cells in peripheral blood
description	Christopher Fugl Madelung,1,2 Mads Krüger Falk,1,2 Torben Lykke Sørensen1,2 1Clinical Eye Research Unit, Department of Ophthalmology, Copenhagen University Hospital, Roskilde, Denmark; 2University of Copenhagen, Copenhagen, Denmark Purpose: To investigate regulatory T cells (Tregs) and subsets of the Treg population in patients with neovascular age-related macular degeneration (AMD).Patients and methods: Twenty-one neovascular AMD cases and 12 age-matched controls without retinal pathology were selected. Patients were recruited from our outpatient retinal clinic. Control individuals were typically spouses. The diagnosis of neovascular AMD was confirmed using fluorescein and indocyaningreen angiography. Fresh venous blood was analyzed by flow cytometry using fluorochrome-conjugated antibodies to the Treg surface antigens CD4, CD25, CD127, CD45RA, and CD31. Main outcome measures were the percentage of CD25highCD127low Tregs, the percentage of CD45RA+ naïve Tregs, and the percentage of CD31+ recent thymic emigrant Tregs.Results: Comparing patients with neovascular AMD to controls, no significant differences were found in the percentages of CD4+ lymphocytes, CD25highCD127low Tregs, CD45RA+ naïve Tregs, or CD31+ recent thymic emigrant Tregs.Conclusion: Our data does not indicate an altered state of systemic Treg cells in neovascular AMD. Keywords: Tregs, macular degeneration, immunosenescence, CD45RA antigens, CD31 antigens
format	article
author	Madelung CF Falk MK Sørensen TL
author_facet	Madelung CF Falk MK Sørensen TL
author_sort	Madelung CF
title	The association between neovascular age-related macular degeneration and regulatory T cells in peripheral blood
title_short	The association between neovascular age-related macular degeneration and regulatory T cells in peripheral blood
title_full	The association between neovascular age-related macular degeneration and regulatory T cells in peripheral blood
title_fullStr	The association between neovascular age-related macular degeneration and regulatory T cells in peripheral blood
title_full_unstemmed	The association between neovascular age-related macular degeneration and regulatory T cells in peripheral blood
title_sort	association between neovascular age-related macular degeneration and regulatory t cells in peripheral blood
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/c28b6f8fbf414f17b7730e355a12836a
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The association between neovascular age-related macular degeneration and regulatory T cells in&nbsp;peripheral blood

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