Diagnostic accuracy of urine dipstick testing for albumin-to-creatinine ratio and albuminuria: A systematic review and meta-analysis

Background: The accuracy of urine dipsticks to detect increased albuminuria is uncertain. We aimed to assess the diagnostic accuracy of urine dipsticks for detecting albuminuria. Methods: A systematic review of studies that assessed the diagnostic accuracy of urine dipstick testing for detecting alb...

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Autores principales:	Jhonatan R. Mejia, Jose Ernesto Fernandez-Chinguel, Gandy Dolores-Maldonado, Naysha Becerra-Chauca, Sergio Goicochea-Lugo, Percy Herrera-Añazco, Jessica Hanae Zafra-Tanaka, Alvaro Taype-Rondan
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Albuminuria Sensitivity and specificity Renal insufficiency Chronic Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/c28c09640d434e74a95344e5ec49be0b
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spelling	oai:doaj.org-article:c28c09640d434e74a95344e5ec49be0b2021-12-02T05:02:17ZDiagnostic accuracy of urine dipstick testing for albumin-to-creatinine ratio and albuminuria: A systematic review and meta-analysis2405-844010.1016/j.heliyon.2021.e08253https://doaj.org/article/c28c09640d434e74a95344e5ec49be0b2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021023562https://doaj.org/toc/2405-8440Background: The accuracy of urine dipsticks to detect increased albuminuria is uncertain. We aimed to assess the diagnostic accuracy of urine dipsticks for detecting albuminuria. Methods: A systematic review of studies that assessed the diagnostic accuracy of urine dipstick testing for detecting albuminuria has been conducted (using as reference standard the albuminuria in a 24-hour sample or the albumin-to-creatinine ratio) in Scopus, PubMed, and Google Scholar. The risk of bias of the included studies has been assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. Whenever possible, we performed meta-analyses for sensitivity and specificity. The certainty of the evidence has also been assessed using the Grading of Recommendations Assessment, Development, and Evaluation methodology. Results: A total of 14 studies have been included in this review, having assessed all albumin-to-creatinine ratio (ACR) as assessed standard. Each study used different dipstick types. The resulting pooled sensitivity and specificity for each cutoff point were as follows: for ACR >30 mg/g (13 studies): 0.82 (95% confidence interval: 0.76–0.87) and 0.88 (0.83–0.91); for ACR 30–300 mg/g (7 studies): 0.72 (0.68–0.77) and 0.82 (0.76–0.89); and for ACR >300 mg/g (7 studies): 0.84 (0.71–0.90) and 0.97 (0.95–0.99), respectively. An overall high risk of bias, an important heterogeneity in all pooled analysis, and a very low certainty of the evidence have been found. Conclusions: Pooled sensitivity and specificity of urine dipsticks have been calculated for different ACR cutoff points. However, the dipstick types differed across studies, and the certainty of the evidence was very low. Thus, further well-designed studies are needed to reach more confident estimates and to assess accuracy differences across dipstick types. Registration: PROSPERO (CRD42019124637).Jhonatan R. MejiaJose Ernesto Fernandez-ChinguelGandy Dolores-MaldonadoNaysha Becerra-ChaucaSergio Goicochea-LugoPercy Herrera-AñazcoJessica Hanae Zafra-TanakaAlvaro Taype-RondanElsevierarticleAlbuminuriaSensitivity and specificityRenal insufficiencyChronicScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08253- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Albuminuria Sensitivity and specificity Renal insufficiency Chronic Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Albuminuria Sensitivity and specificity Renal insufficiency Chronic Science (General) Q1-390 Social sciences (General) H1-99 Jhonatan R. Mejia Jose Ernesto Fernandez-Chinguel Gandy Dolores-Maldonado Naysha Becerra-Chauca Sergio Goicochea-Lugo Percy Herrera-Añazco Jessica Hanae Zafra-Tanaka Alvaro Taype-Rondan Diagnostic accuracy of urine dipstick testing for albumin-to-creatinine ratio and albuminuria: A systematic review and meta-analysis
description	Background: The accuracy of urine dipsticks to detect increased albuminuria is uncertain. We aimed to assess the diagnostic accuracy of urine dipsticks for detecting albuminuria. Methods: A systematic review of studies that assessed the diagnostic accuracy of urine dipstick testing for detecting albuminuria has been conducted (using as reference standard the albuminuria in a 24-hour sample or the albumin-to-creatinine ratio) in Scopus, PubMed, and Google Scholar. The risk of bias of the included studies has been assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. Whenever possible, we performed meta-analyses for sensitivity and specificity. The certainty of the evidence has also been assessed using the Grading of Recommendations Assessment, Development, and Evaluation methodology. Results: A total of 14 studies have been included in this review, having assessed all albumin-to-creatinine ratio (ACR) as assessed standard. Each study used different dipstick types. The resulting pooled sensitivity and specificity for each cutoff point were as follows: for ACR >30 mg/g (13 studies): 0.82 (95% confidence interval: 0.76–0.87) and 0.88 (0.83–0.91); for ACR 30–300 mg/g (7 studies): 0.72 (0.68–0.77) and 0.82 (0.76–0.89); and for ACR >300 mg/g (7 studies): 0.84 (0.71–0.90) and 0.97 (0.95–0.99), respectively. An overall high risk of bias, an important heterogeneity in all pooled analysis, and a very low certainty of the evidence have been found. Conclusions: Pooled sensitivity and specificity of urine dipsticks have been calculated for different ACR cutoff points. However, the dipstick types differed across studies, and the certainty of the evidence was very low. Thus, further well-designed studies are needed to reach more confident estimates and to assess accuracy differences across dipstick types. Registration: PROSPERO (CRD42019124637).
format	article
author	Jhonatan R. Mejia Jose Ernesto Fernandez-Chinguel Gandy Dolores-Maldonado Naysha Becerra-Chauca Sergio Goicochea-Lugo Percy Herrera-Añazco Jessica Hanae Zafra-Tanaka Alvaro Taype-Rondan
author_facet	Jhonatan R. Mejia Jose Ernesto Fernandez-Chinguel Gandy Dolores-Maldonado Naysha Becerra-Chauca Sergio Goicochea-Lugo Percy Herrera-Añazco Jessica Hanae Zafra-Tanaka Alvaro Taype-Rondan
author_sort	Jhonatan R. Mejia
title	Diagnostic accuracy of urine dipstick testing for albumin-to-creatinine ratio and albuminuria: A systematic review and meta-analysis
title_short	Diagnostic accuracy of urine dipstick testing for albumin-to-creatinine ratio and albuminuria: A systematic review and meta-analysis
title_full	Diagnostic accuracy of urine dipstick testing for albumin-to-creatinine ratio and albuminuria: A systematic review and meta-analysis
title_fullStr	Diagnostic accuracy of urine dipstick testing for albumin-to-creatinine ratio and albuminuria: A systematic review and meta-analysis
title_full_unstemmed	Diagnostic accuracy of urine dipstick testing for albumin-to-creatinine ratio and albuminuria: A systematic review and meta-analysis
title_sort	diagnostic accuracy of urine dipstick testing for albumin-to-creatinine ratio and albuminuria: a systematic review and meta-analysis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c28c09640d434e74a95344e5ec49be0b
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Diagnostic accuracy of urine dipstick testing for albumin-to-creatinine ratio and albuminuria: A systematic review and meta-analysis

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