ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types

The transcription factors ZEB1 and YAP function in different pathways yet both activate aggressive behaviour in cancer cells. Here, the authors describe that the proteins physically interact and that this changes the transcriptional activity of ZEB1 from a repressor to an activator.

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Detalles Bibliográficos
Autores principales:	Waltraut Lehmann, Dirk Mossmann, Julia Kleemann, Kerstin Mock, Chris Meisinger, Tilman Brummer, Ricarda Herr, Simone Brabletz, Marc P. Stemmler, Thomas Brabletz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c28d750a3a21475fbd801e7e361107d4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:c28d750a3a21475fbd801e7e361107d42021-12-02T14:40:11ZZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types10.1038/ncomms104982041-1723https://doaj.org/article/c28d750a3a21475fbd801e7e361107d42016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10498https://doaj.org/toc/2041-1723The transcription factors ZEB1 and YAP function in different pathways yet both activate aggressive behaviour in cancer cells. Here, the authors describe that the proteins physically interact and that this changes the transcriptional activity of ZEB1 from a repressor to an activator.Waltraut LehmannDirk MossmannJulia KleemannKerstin MockChris MeisingerTilman BrummerRicarda HerrSimone BrabletzMarc P. StemmlerThomas BrabletzNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Waltraut Lehmann Dirk Mossmann Julia Kleemann Kerstin Mock Chris Meisinger Tilman Brummer Ricarda Herr Simone Brabletz Marc P. Stemmler Thomas Brabletz ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types
description	The transcription factors ZEB1 and YAP function in different pathways yet both activate aggressive behaviour in cancer cells. Here, the authors describe that the proteins physically interact and that this changes the transcriptional activity of ZEB1 from a repressor to an activator.
format	article
author	Waltraut Lehmann Dirk Mossmann Julia Kleemann Kerstin Mock Chris Meisinger Tilman Brummer Ricarda Herr Simone Brabletz Marc P. Stemmler Thomas Brabletz
author_facet	Waltraut Lehmann Dirk Mossmann Julia Kleemann Kerstin Mock Chris Meisinger Tilman Brummer Ricarda Herr Simone Brabletz Marc P. Stemmler Thomas Brabletz
author_sort	Waltraut Lehmann
title	ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types
title_short	ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types
title_full	ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types
title_fullStr	ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types
title_full_unstemmed	ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types
title_sort	zeb1 turns into a transcriptional activator by interacting with yap1 in aggressive cancer types
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c28d750a3a21475fbd801e7e361107d4
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ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types

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