Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma

Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma

Lipid accumulation in the liver leads to nonalcoholic fatty liver disease (NAFLD) that is a risk factor for developing hepatocellular carcinoma (HCC). Here, the authors show that activation of the translation initiation factor eIF6 promotes lipid accumulation in the liver and targeting eIF6 in murin...

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Autores principales: Alessandra Scagliola, Annarita Miluzio, Gabriele Ventura, Stefania Oliveto, Chiara Cordiglieri, Nicola Manfrini, Delia Cirino, Sara Ricciardi, Luca Valenti, Guido Baselli, Roberta D’Ambrosio, Marco Maggioni, Daniela Brina, Alberto Bresciani, Stefano Biffo
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c2901b240ab0477f819e12cbe5532a69
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spelling oai:doaj.org-article:c2901b240ab0477f819e12cbe5532a692021-12-02T15:08:12ZTargeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma10.1038/s41467-021-25195-12041-1723https://doaj.org/article/c2901b240ab0477f819e12cbe5532a692021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25195-1https://doaj.org/toc/2041-1723Lipid accumulation in the liver leads to nonalcoholic fatty liver disease (NAFLD) that is a risk factor for developing hepatocellular carcinoma (HCC). Here, the authors show that activation of the translation initiation factor eIF6 promotes lipid accumulation in the liver and targeting eIF6 in murine models reduces NAFLD and associated HCC.Alessandra ScagliolaAnnarita MiluzioGabriele VenturaStefania OlivetoChiara CordiglieriNicola ManfriniDelia CirinoSara RicciardiLuca ValentiGuido BaselliRoberta D’AmbrosioMarco MaggioniDaniela BrinaAlberto BrescianiStefano BiffoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Alessandra Scagliola
Annarita Miluzio
Gabriele Ventura
Stefania Oliveto
Chiara Cordiglieri
Nicola Manfrini
Delia Cirino
Sara Ricciardi
Luca Valenti
Guido Baselli
Roberta D’Ambrosio
Marco Maggioni
Daniela Brina
Alberto Bresciani
Stefano Biffo
Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma
description Lipid accumulation in the liver leads to nonalcoholic fatty liver disease (NAFLD) that is a risk factor for developing hepatocellular carcinoma (HCC). Here, the authors show that activation of the translation initiation factor eIF6 promotes lipid accumulation in the liver and targeting eIF6 in murine models reduces NAFLD and associated HCC.
format article
author Alessandra Scagliola
Annarita Miluzio
Gabriele Ventura
Stefania Oliveto
Chiara Cordiglieri
Nicola Manfrini
Delia Cirino
Sara Ricciardi
Luca Valenti
Guido Baselli
Roberta D’Ambrosio
Marco Maggioni
Daniela Brina
Alberto Bresciani
Stefano Biffo
author_facet Alessandra Scagliola
Annarita Miluzio
Gabriele Ventura
Stefania Oliveto
Chiara Cordiglieri
Nicola Manfrini
Delia Cirino
Sara Ricciardi
Luca Valenti
Guido Baselli
Roberta D’Ambrosio
Marco Maggioni
Daniela Brina
Alberto Bresciani
Stefano Biffo
author_sort Alessandra Scagliola
title Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma
title_short Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma
title_full Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma
title_fullStr Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma
title_full_unstemmed Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma
title_sort targeting of eif6-driven translation induces a metabolic rewiring that reduces nafld and the consequent evolution to hepatocellular carcinoma
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c2901b240ab0477f819e12cbe5532a69
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