The Effect of Moringa Oleifera. Lam Leaf Extract on Bcl2 and Bax Expression in Paracetamol-induced Renal Tubular Apoptosis in Rats

BACKGROUND: Paracetamol may cause apoptosis in the renal tubules. Moringa leaf (Moringa oleifera. Lam) has been shown to have antioxidant effects due to its f lavonoids. In addition, f lavonoids also have biological effects to modulate the signal-transduction pathway. OBJECTIVE: to investigate the...

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Autores principales:	Miftahul Jannah, Djoko Trihadi Lukmono Subagyo, Taufiqurrachman Nasihun
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Sultan Agung Semarang 2018
Materias:	moringa leaf bcl2 expression bax expression Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c293fac3bbbe4c508d72cf1510bf375d
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spelling	oai:doaj.org-article:c293fac3bbbe4c508d72cf1510bf375d2021-11-25T13:15:53ZThe Effect of Moringa Oleifera. Lam Leaf Extract on Bcl2 and Bax Expression in Paracetamol-induced Renal Tubular Apoptosis in Rats2085-15452339-093X10.26532/sainsmed.v8i2.1054https://doaj.org/article/c293fac3bbbe4c508d72cf1510bf375d2018-03-01T00:00:00Zhttp://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/1054https://doaj.org/toc/2085-1545https://doaj.org/toc/2339-093XBACKGROUND: Paracetamol may cause apoptosis in the renal tubules. Moringa leaf (Moringa oleifera. Lam) has been shown to have antioxidant effects due to its f lavonoids. In addition, f lavonoids also have biological effects to modulate the signal-transduction pathway. OBJECTIVE: to investigate the effect of Moringa oleifera Lam extract on Bcl-2 and Bax expression on paracetamol-induced renal tubular injury. METHODS: in this post-test only control group design study, 24 rats were divided into 4 groups: AqC-G (aquades), EtC-G (70% ethanol), MoL1-G and MoL2-G (moringa leaf extract at the dose of 1.075 g/Kg BW and 2.150 g/Kg BW respectively). Expression of Bcl2 and Bax was determined using immunohistochemical staining. The data on the number of Bcl2 and Bax expressions tested with One Way Anova followed by the Post Hoc LSD test. RESULTS: Post Hoc LSD test showed that the expression of Bcl-2 in the experimental groups ((MoL1-G (9.1) and MoL2-G (13,683)) was significantly higher compared to that of controls (p<0.001). Bax expression in the experimental groups (MoL1-G (6,85) and MoL2-G (2,633)) was significantly lower compared to that of controls, p <0.001. CONCLUSION: The administration of Moringa leaf extract at the dose of 1,075 and 2,150 increases Bcl-2 expression and decreases Bax expression in paracetamol-induced renal tubular injury.Miftahul JannahDjoko Trihadi Lukmono SubagyoTaufiqurrachman NasihunUniversitas Sultan Agung Semarangarticlemoringa leafbcl2 expressionbax expressionMedicine (General)R5-920ENSains Medika, Vol 8, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	moringa leaf bcl2 expression bax expression Medicine (General) R5-920
spellingShingle	moringa leaf bcl2 expression bax expression Medicine (General) R5-920 Miftahul Jannah Djoko Trihadi Lukmono Subagyo Taufiqurrachman Nasihun The Effect of Moringa Oleifera. Lam Leaf Extract on Bcl2 and Bax Expression in Paracetamol-induced Renal Tubular Apoptosis in Rats
description	BACKGROUND: Paracetamol may cause apoptosis in the renal tubules. Moringa leaf (Moringa oleifera. Lam) has been shown to have antioxidant effects due to its f lavonoids. In addition, f lavonoids also have biological effects to modulate the signal-transduction pathway. OBJECTIVE: to investigate the effect of Moringa oleifera Lam extract on Bcl-2 and Bax expression on paracetamol-induced renal tubular injury. METHODS: in this post-test only control group design study, 24 rats were divided into 4 groups: AqC-G (aquades), EtC-G (70% ethanol), MoL1-G and MoL2-G (moringa leaf extract at the dose of 1.075 g/Kg BW and 2.150 g/Kg BW respectively). Expression of Bcl2 and Bax was determined using immunohistochemical staining. The data on the number of Bcl2 and Bax expressions tested with One Way Anova followed by the Post Hoc LSD test. RESULTS: Post Hoc LSD test showed that the expression of Bcl-2 in the experimental groups ((MoL1-G (9.1) and MoL2-G (13,683)) was significantly higher compared to that of controls (p<0.001). Bax expression in the experimental groups (MoL1-G (6,85) and MoL2-G (2,633)) was significantly lower compared to that of controls, p <0.001. CONCLUSION: The administration of Moringa leaf extract at the dose of 1,075 and 2,150 increases Bcl-2 expression and decreases Bax expression in paracetamol-induced renal tubular injury.
format	article
author	Miftahul Jannah Djoko Trihadi Lukmono Subagyo Taufiqurrachman Nasihun
author_facet	Miftahul Jannah Djoko Trihadi Lukmono Subagyo Taufiqurrachman Nasihun
author_sort	Miftahul Jannah
title	The Effect of Moringa Oleifera. Lam Leaf Extract on Bcl2 and Bax Expression in Paracetamol-induced Renal Tubular Apoptosis in Rats
title_short	The Effect of Moringa Oleifera. Lam Leaf Extract on Bcl2 and Bax Expression in Paracetamol-induced Renal Tubular Apoptosis in Rats
title_full	The Effect of Moringa Oleifera. Lam Leaf Extract on Bcl2 and Bax Expression in Paracetamol-induced Renal Tubular Apoptosis in Rats
title_fullStr	The Effect of Moringa Oleifera. Lam Leaf Extract on Bcl2 and Bax Expression in Paracetamol-induced Renal Tubular Apoptosis in Rats
title_full_unstemmed	The Effect of Moringa Oleifera. Lam Leaf Extract on Bcl2 and Bax Expression in Paracetamol-induced Renal Tubular Apoptosis in Rats
title_sort	effect of moringa oleifera. lam leaf extract on bcl2 and bax expression in paracetamol-induced renal tubular apoptosis in rats
publisher	Universitas Sultan Agung Semarang
publishDate	2018
url	https://doaj.org/article/c293fac3bbbe4c508d72cf1510bf375d
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The Effect of Moringa Oleifera. Lam Leaf Extract on Bcl2 and Bax Expression in Paracetamol-induced Renal Tubular Apoptosis in Rats

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