Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus

Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus

Author summary Bone mineral density and lean skeletal mass are heritable traits. Here, Medina-Gomez and colleagues perform bivariate GWAS analyses of total body lean mass and bone mass density in children, and show genetic loci with pleiotropic effects on both traits.

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Autores principales: Carolina Medina-Gomez, John P. Kemp, Niki L. Dimou, Eskil Kreiner, Alessandra Chesi, Babette S. Zemel, Klaus Bønnelykke, Cindy G. Boer, Tarunveer S. Ahluwalia, Hans Bisgaard, Evangelos Evangelou, Denise H. M. Heppe, Lynda F. Bonewald, Jeffrey P. Gorski, Mohsen Ghanbari, Serkalem Demissie, Gustavo Duque, Matthew T. Maurano, Douglas P. Kiel, Yi-Hsiang Hsu, Bram C.J. van der Eerden, Cheryl Ackert-Bicknell, Sjur Reppe, Kaare M. Gautvik, Truls Raastad, David Karasik, Jeroen van de Peppel, Vincent W. V. Jaddoe, André G. Uitterlinden, Jonathan H. Tobias, Struan F.A. Grant, Pantelis G. Bagos, David M. Evans, Fernando Rivadeneira
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/c29862cdbe2e426d82346b87b13a5d6e
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spelling oai:doaj.org-article:c29862cdbe2e426d82346b87b13a5d6e2021-12-02T13:57:33ZBivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus10.1038/s41467-017-00108-32041-1723https://doaj.org/article/c29862cdbe2e426d82346b87b13a5d6e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00108-3https://doaj.org/toc/2041-1723Author summary Bone mineral density and lean skeletal mass are heritable traits. Here, Medina-Gomez and colleagues perform bivariate GWAS analyses of total body lean mass and bone mass density in children, and show genetic loci with pleiotropic effects on both traits.Carolina Medina-GomezJohn P. KempNiki L. DimouEskil KreinerAlessandra ChesiBabette S. ZemelKlaus BønnelykkeCindy G. BoerTarunveer S. AhluwaliaHans BisgaardEvangelos EvangelouDenise H. M. HeppeLynda F. BonewaldJeffrey P. GorskiMohsen GhanbariSerkalem DemissieGustavo DuqueMatthew T. MauranoDouglas P. KielYi-Hsiang HsuBram C.J. van der EerdenCheryl Ackert-BicknellSjur ReppeKaare M. GautvikTruls RaastadDavid KarasikJeroen van de PeppelVincent W. V. JaddoeAndré G. UitterlindenJonathan H. TobiasStruan F.A. GrantPantelis G. BagosDavid M. EvansFernando RivadeneiraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Carolina Medina-Gomez
John P. Kemp
Niki L. Dimou
Eskil Kreiner
Alessandra Chesi
Babette S. Zemel
Klaus Bønnelykke
Cindy G. Boer
Tarunveer S. Ahluwalia
Hans Bisgaard
Evangelos Evangelou
Denise H. M. Heppe
Lynda F. Bonewald
Jeffrey P. Gorski
Mohsen Ghanbari
Serkalem Demissie
Gustavo Duque
Matthew T. Maurano
Douglas P. Kiel
Yi-Hsiang Hsu
Bram C.J. van der Eerden
Cheryl Ackert-Bicknell
Sjur Reppe
Kaare M. Gautvik
Truls Raastad
David Karasik
Jeroen van de Peppel
Vincent W. V. Jaddoe
André G. Uitterlinden
Jonathan H. Tobias
Struan F.A. Grant
Pantelis G. Bagos
David M. Evans
Fernando Rivadeneira
Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus
description Author summary Bone mineral density and lean skeletal mass are heritable traits. Here, Medina-Gomez and colleagues perform bivariate GWAS analyses of total body lean mass and bone mass density in children, and show genetic loci with pleiotropic effects on both traits.
format article
author Carolina Medina-Gomez
John P. Kemp
Niki L. Dimou
Eskil Kreiner
Alessandra Chesi
Babette S. Zemel
Klaus Bønnelykke
Cindy G. Boer
Tarunveer S. Ahluwalia
Hans Bisgaard
Evangelos Evangelou
Denise H. M. Heppe
Lynda F. Bonewald
Jeffrey P. Gorski
Mohsen Ghanbari
Serkalem Demissie
Gustavo Duque
Matthew T. Maurano
Douglas P. Kiel
Yi-Hsiang Hsu
Bram C.J. van der Eerden
Cheryl Ackert-Bicknell
Sjur Reppe
Kaare M. Gautvik
Truls Raastad
David Karasik
Jeroen van de Peppel
Vincent W. V. Jaddoe
André G. Uitterlinden
Jonathan H. Tobias
Struan F.A. Grant
Pantelis G. Bagos
David M. Evans
Fernando Rivadeneira
author_facet Carolina Medina-Gomez
John P. Kemp
Niki L. Dimou
Eskil Kreiner
Alessandra Chesi
Babette S. Zemel
Klaus Bønnelykke
Cindy G. Boer
Tarunveer S. Ahluwalia
Hans Bisgaard
Evangelos Evangelou
Denise H. M. Heppe
Lynda F. Bonewald
Jeffrey P. Gorski
Mohsen Ghanbari
Serkalem Demissie
Gustavo Duque
Matthew T. Maurano
Douglas P. Kiel
Yi-Hsiang Hsu
Bram C.J. van der Eerden
Cheryl Ackert-Bicknell
Sjur Reppe
Kaare M. Gautvik
Truls Raastad
David Karasik
Jeroen van de Peppel
Vincent W. V. Jaddoe
André G. Uitterlinden
Jonathan H. Tobias
Struan F.A. Grant
Pantelis G. Bagos
David M. Evans
Fernando Rivadeneira
author_sort Carolina Medina-Gomez
title Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus
title_short Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus
title_full Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus
title_fullStr Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus
title_full_unstemmed Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus
title_sort bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the srebf1/tom1l2 locus
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/c29862cdbe2e426d82346b87b13a5d6e
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