A CASE REPORT OF IMIPENEM-INDUCED SEIZURE DUE TO DRUG INTERACTION AND ACCIDENTAL HIGH DOSE

BACKGROUND AND OBJECTIVE: Although most antibiotics are safe for central nervous system (CNS) and their neurotoxicity is infrequent, beta-lactam antibiotics (especially imipenem) are most commonly antibacterial agents associated with CNS adverse events such as seizure. In this report a case of impor...

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Autores principales:	M Rafati, SH Ala
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2008
Materias:	imipenem seizure adverse drug reaction drug interaction Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c29961f174204c9aacb33347d6816436
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spelling	oai:doaj.org-article:c29961f174204c9aacb33347d68164362021-11-10T09:07:28ZA CASE REPORT OF IMIPENEM-INDUCED SEIZURE DUE TO DRUG INTERACTION AND ACCIDENTAL HIGH DOSE1561-41072251-7170https://doaj.org/article/c29961f174204c9aacb33347d68164362008-06-01T00:00:00Zhttp://jbums.org/article-1-2997-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Although most antibiotics are safe for central nervous system (CNS) and their neurotoxicity is infrequent, beta-lactam antibiotics (especially imipenem) are most commonly antibacterial agents associated with CNS adverse events such as seizure. In this report a case of important drug interaction following imipenem administration was introduced.CASE: A 66 year old man was presented with chief complaint of abdominal pain and difficulty to eat food. After diagnosis of cardia cancer (adenocarcinoma), the patient underwent laparotomy and total gastrectomy and transported to the intensive care unit (ICU). Due to respiratory infection, imipenem (1.5 g per 6 hrs) and ciprofloxacin (750 mg per 8 hrs) ordered and the patient experienced a resistant seizure after the third doses of imipenem that was not improved with diazepam and phenytoin and controlled after using thiopental. After controlling seizure, administration of phenytoin with maintenance dose continued and the patient did not regain consciousness degree that he had before the occurrence of seizure. Two week later, the patient died due to septic shock and severe physiological instability while the seizure was one of the main causes of his complication and mortality.CONCLUSION: Unintentional using of higher doses of imipenem and ciprofloxacin (4g and 1500mg, respectively and co-administration of them in critically ill patient produced severe seizure. With determination of assistant factors (high age and decreased renal function) and removing of risk factors (high dose and co-administration of two or more suspected drugs), these dangerous adverse reactions can be prevented.M Rafati,SH AlaBabol University of Medical Sciencesarticleimipenemseizureadverse drug reactiondrug interactionMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 10, Iss 2, Pp 82-86 (2008)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	imipenem seizure adverse drug reaction drug interaction Medicine R Medicine (General) R5-920
spellingShingle	imipenem seizure adverse drug reaction drug interaction Medicine R Medicine (General) R5-920 M Rafati, SH Ala A CASE REPORT OF IMIPENEM-INDUCED SEIZURE DUE TO DRUG INTERACTION AND ACCIDENTAL HIGH DOSE
description	BACKGROUND AND OBJECTIVE: Although most antibiotics are safe for central nervous system (CNS) and their neurotoxicity is infrequent, beta-lactam antibiotics (especially imipenem) are most commonly antibacterial agents associated with CNS adverse events such as seizure. In this report a case of important drug interaction following imipenem administration was introduced.CASE: A 66 year old man was presented with chief complaint of abdominal pain and difficulty to eat food. After diagnosis of cardia cancer (adenocarcinoma), the patient underwent laparotomy and total gastrectomy and transported to the intensive care unit (ICU). Due to respiratory infection, imipenem (1.5 g per 6 hrs) and ciprofloxacin (750 mg per 8 hrs) ordered and the patient experienced a resistant seizure after the third doses of imipenem that was not improved with diazepam and phenytoin and controlled after using thiopental. After controlling seizure, administration of phenytoin with maintenance dose continued and the patient did not regain consciousness degree that he had before the occurrence of seizure. Two week later, the patient died due to septic shock and severe physiological instability while the seizure was one of the main causes of his complication and mortality.CONCLUSION: Unintentional using of higher doses of imipenem and ciprofloxacin (4g and 1500mg, respectively and co-administration of them in critically ill patient produced severe seizure. With determination of assistant factors (high age and decreased renal function) and removing of risk factors (high dose and co-administration of two or more suspected drugs), these dangerous adverse reactions can be prevented.
format	article
author	M Rafati, SH Ala
author_facet	M Rafati, SH Ala
author_sort	M Rafati,
title	A CASE REPORT OF IMIPENEM-INDUCED SEIZURE DUE TO DRUG INTERACTION AND ACCIDENTAL HIGH DOSE
title_short	A CASE REPORT OF IMIPENEM-INDUCED SEIZURE DUE TO DRUG INTERACTION AND ACCIDENTAL HIGH DOSE
title_full	A CASE REPORT OF IMIPENEM-INDUCED SEIZURE DUE TO DRUG INTERACTION AND ACCIDENTAL HIGH DOSE
title_fullStr	A CASE REPORT OF IMIPENEM-INDUCED SEIZURE DUE TO DRUG INTERACTION AND ACCIDENTAL HIGH DOSE
title_full_unstemmed	A CASE REPORT OF IMIPENEM-INDUCED SEIZURE DUE TO DRUG INTERACTION AND ACCIDENTAL HIGH DOSE
title_sort	case report of imipenem-induced seizure due to drug interaction and accidental high dose
publisher	Babol University of Medical Sciences
publishDate	2008
url	https://doaj.org/article/c29961f174204c9aacb33347d6816436
work_keys_str_mv	AT mrafati acasereportofimipeneminducedseizureduetodruginteractionandaccidentalhighdose AT shala acasereportofimipeneminducedseizureduetodruginteractionandaccidentalhighdose AT mrafati casereportofimipeneminducedseizureduetodruginteractionandaccidentalhighdose AT shala casereportofimipeneminducedseizureduetodruginteractionandaccidentalhighdose
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A CASE REPORT OF IMIPENEM-INDUCED SEIZURE DUE TO DRUG INTERACTION AND ACCIDENTAL HIGH DOSE

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