MicroRNAs in Molecular Classification and Pathogenesis of Breast Tumors

The current clinical practice of breast tumor classification relies on the routine immunohistochemistry-based expression analysis of hormone receptors, which is inadequate in addressing breast tumor heterogeneity and drug resistance. MicroRNA expression profiling in tumor tissue and in the circulati...

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Autores principales:	Vinitha Richard, Matthew G. Davey, Heidi Annuk, Nicola Miller, Róisín M. Dwyer, Aoife Lowery, Michael J. Kerin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microRNAs breast cancer molecular classification intrinsic subtypes hormone receptors cancer stem cells Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/c29e8ad5d7204bdc94ccd16a27c35f5c
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spelling	oai:doaj.org-article:c29e8ad5d7204bdc94ccd16a27c35f5c2021-11-11T15:28:31ZMicroRNAs in Molecular Classification and Pathogenesis of Breast Tumors10.3390/cancers132153322072-6694https://doaj.org/article/c29e8ad5d7204bdc94ccd16a27c35f5c2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5332https://doaj.org/toc/2072-6694The current clinical practice of breast tumor classification relies on the routine immunohistochemistry-based expression analysis of hormone receptors, which is inadequate in addressing breast tumor heterogeneity and drug resistance. MicroRNA expression profiling in tumor tissue and in the circulation is an efficient alternative to intrinsic molecular subtyping that enables precise molecular classification of breast tumor variants, the prediction of tumor progression, risk stratification and also identifies critical regulators of the tumor microenvironment. This review integrates data from protein, gene and miRNA expression studies to elaborate on a unique miRNA-based 10-subtype taxonomy, which we propose as the current gold standard to allow appropriate classification and separation of breast cancer into a targetable strategy for therapy.Vinitha RichardMatthew G. DaveyHeidi AnnukNicola MillerRóisín M. DwyerAoife LoweryMichael J. KerinMDPI AGarticlemicroRNAsbreast cancermolecular classificationintrinsic subtypeshormone receptorscancer stem cellsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5332, p 5332 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microRNAs breast cancer molecular classification intrinsic subtypes hormone receptors cancer stem cells Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	microRNAs breast cancer molecular classification intrinsic subtypes hormone receptors cancer stem cells Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Vinitha Richard Matthew G. Davey Heidi Annuk Nicola Miller Róisín M. Dwyer Aoife Lowery Michael J. Kerin MicroRNAs in Molecular Classification and Pathogenesis of Breast Tumors
description	The current clinical practice of breast tumor classification relies on the routine immunohistochemistry-based expression analysis of hormone receptors, which is inadequate in addressing breast tumor heterogeneity and drug resistance. MicroRNA expression profiling in tumor tissue and in the circulation is an efficient alternative to intrinsic molecular subtyping that enables precise molecular classification of breast tumor variants, the prediction of tumor progression, risk stratification and also identifies critical regulators of the tumor microenvironment. This review integrates data from protein, gene and miRNA expression studies to elaborate on a unique miRNA-based 10-subtype taxonomy, which we propose as the current gold standard to allow appropriate classification and separation of breast cancer into a targetable strategy for therapy.
format	article
author	Vinitha Richard Matthew G. Davey Heidi Annuk Nicola Miller Róisín M. Dwyer Aoife Lowery Michael J. Kerin
author_facet	Vinitha Richard Matthew G. Davey Heidi Annuk Nicola Miller Róisín M. Dwyer Aoife Lowery Michael J. Kerin
author_sort	Vinitha Richard
title	MicroRNAs in Molecular Classification and Pathogenesis of Breast Tumors
title_short	MicroRNAs in Molecular Classification and Pathogenesis of Breast Tumors
title_full	MicroRNAs in Molecular Classification and Pathogenesis of Breast Tumors
title_fullStr	MicroRNAs in Molecular Classification and Pathogenesis of Breast Tumors
title_full_unstemmed	MicroRNAs in Molecular Classification and Pathogenesis of Breast Tumors
title_sort	micrornas in molecular classification and pathogenesis of breast tumors
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c29e8ad5d7204bdc94ccd16a27c35f5c
work_keys_str_mv	AT vinitharichard micrornasinmolecularclassificationandpathogenesisofbreasttumors AT matthewgdavey micrornasinmolecularclassificationandpathogenesisofbreasttumors AT heidiannuk micrornasinmolecularclassificationandpathogenesisofbreasttumors AT nicolamiller micrornasinmolecularclassificationandpathogenesisofbreasttumors AT roisinmdwyer micrornasinmolecularclassificationandpathogenesisofbreasttumors AT aoifelowery micrornasinmolecularclassificationandpathogenesisofbreasttumors AT michaeljkerin micrornasinmolecularclassificationandpathogenesisofbreasttumors
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MicroRNAs in Molecular Classification and Pathogenesis of Breast Tumors

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