Structural basis of RIP2 activation and signaling

The pathogen recognition receptors NOD1/2 recognize bacterial cell wall components and signal through their downstream adapter kinase RIP2 via a CARD (Caspase activation and recruitment domain) mediated oligomerization process. Here the authors present the cryo-EM structure of the active RIP2-CARD f...

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Autores principales:	Qin Gong, Ziqi Long, Franklin L. Zhong, Daniel Eng Thiam Teo, Yibo Jin, Zhan Yin, Zhao Zhi Boo, Yaming Zhang, Jiawen Zhang, Renliang Yang, Shashi Bhushan, Bruno Reversade, Zongli Li, Bin Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c29ed6dc071e4abb9215cc7c527e42b9
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spelling	oai:doaj.org-article:c29ed6dc071e4abb9215cc7c527e42b92021-12-02T16:49:22ZStructural basis of RIP2 activation and signaling10.1038/s41467-018-07447-92041-1723https://doaj.org/article/c29ed6dc071e4abb9215cc7c527e42b92018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07447-9https://doaj.org/toc/2041-1723The pathogen recognition receptors NOD1/2 recognize bacterial cell wall components and signal through their downstream adapter kinase RIP2 via a CARD (Caspase activation and recruitment domain) mediated oligomerization process. Here the authors present the cryo-EM structure of the active RIP2-CARD filament and discuss implications for NOD1/2-RIP2 signalling.Qin GongZiqi LongFranklin L. ZhongDaniel Eng Thiam TeoYibo JinZhan YinZhao Zhi BooYaming ZhangJiawen ZhangRenliang YangShashi BhushanBruno ReversadeZongli LiBin WuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qin Gong Ziqi Long Franklin L. Zhong Daniel Eng Thiam Teo Yibo Jin Zhan Yin Zhao Zhi Boo Yaming Zhang Jiawen Zhang Renliang Yang Shashi Bhushan Bruno Reversade Zongli Li Bin Wu Structural basis of RIP2 activation and signaling
description	The pathogen recognition receptors NOD1/2 recognize bacterial cell wall components and signal through their downstream adapter kinase RIP2 via a CARD (Caspase activation and recruitment domain) mediated oligomerization process. Here the authors present the cryo-EM structure of the active RIP2-CARD filament and discuss implications for NOD1/2-RIP2 signalling.
format	article
author	Qin Gong Ziqi Long Franklin L. Zhong Daniel Eng Thiam Teo Yibo Jin Zhan Yin Zhao Zhi Boo Yaming Zhang Jiawen Zhang Renliang Yang Shashi Bhushan Bruno Reversade Zongli Li Bin Wu
author_facet	Qin Gong Ziqi Long Franklin L. Zhong Daniel Eng Thiam Teo Yibo Jin Zhan Yin Zhao Zhi Boo Yaming Zhang Jiawen Zhang Renliang Yang Shashi Bhushan Bruno Reversade Zongli Li Bin Wu
author_sort	Qin Gong
title	Structural basis of RIP2 activation and signaling
title_short	Structural basis of RIP2 activation and signaling
title_full	Structural basis of RIP2 activation and signaling
title_fullStr	Structural basis of RIP2 activation and signaling
title_full_unstemmed	Structural basis of RIP2 activation and signaling
title_sort	structural basis of rip2 activation and signaling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c29ed6dc071e4abb9215cc7c527e42b9
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_version_	1718383360611450880

Structural basis of RIP2 activation and signaling

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