The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited
The molecular switch between how tumour necrosis factor (TNF) controls inflammation versus cell death is less well defined. Here, the authors show that the nuclear receptor retinoic acid receptor gamma is released from the nucleus to disrupt TNF initiated cell death complexes in the cytoplasm.
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Nature Portfolio
2017
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oai:doaj.org-article:c2a2b26baafd482aa19951e1856e3a452021-12-02T15:38:53ZThe cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited10.1038/s41467-017-00496-62041-1723https://doaj.org/article/c2a2b26baafd482aa19951e1856e3a452017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00496-6https://doaj.org/toc/2041-1723The molecular switch between how tumour necrosis factor (TNF) controls inflammation versus cell death is less well defined. Here, the authors show that the nuclear receptor retinoic acid receptor gamma is released from the nucleus to disrupt TNF initiated cell death complexes in the cytoplasm.Qing XuSiriporn JitkaewSwati ChoksiChamila KadigamuwaJianhui QuMoran ChoeJonathan JangChengyu LiuZheng-gang LiuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Qing Xu Siriporn Jitkaew Swati Choksi Chamila Kadigamuwa Jianhui Qu Moran Choe Jonathan Jang Chengyu Liu Zheng-gang Liu The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited |
| description |
The molecular switch between how tumour necrosis factor (TNF) controls inflammation versus cell death is less well defined. Here, the authors show that the nuclear receptor retinoic acid receptor gamma is released from the nucleus to disrupt TNF initiated cell death complexes in the cytoplasm. |
| format |
article |
| author |
Qing Xu Siriporn Jitkaew Swati Choksi Chamila Kadigamuwa Jianhui Qu Moran Choe Jonathan Jang Chengyu Liu Zheng-gang Liu |
| author_facet |
Qing Xu Siriporn Jitkaew Swati Choksi Chamila Kadigamuwa Jianhui Qu Moran Choe Jonathan Jang Chengyu Liu Zheng-gang Liu |
| author_sort |
Qing Xu |
| title |
The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited |
| title_short |
The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited |
| title_full |
The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited |
| title_fullStr |
The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited |
| title_full_unstemmed |
The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited |
| title_sort |
cytoplasmic nuclear receptor rarγ controls rip1 initiated cell death when ciap activity is inhibited |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/c2a2b26baafd482aa19951e1856e3a45 |
| work_keys_str_mv |
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| _version_ |
1718386072822480896 |