CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production

Abstract Eosinophils and their associated cytokines IL-4 and IL-5 are emerging as central orchestrators of the immune-metabolic axis. Herein, we demonstrate that cross-talk between the Ig-superfamily receptor CD300f and IL-5 is a key checkpoint that modifies the ability of eosinophils to regulate me...

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Autores principales:	Perri Rozenberg, Hadar Reichman, Israel Zab-Bar, Michal Itan, Metsada Pasmanik-Chor, Carine Bouffi, Udi Qimron, Ido Bachelet, Patricia C. Fulkerson, Marc E. Rothenberg, Ariel Munitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c2a3e62ec5e140ed9d6934d68101ee2c
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spelling	oai:doaj.org-article:c2a3e62ec5e140ed9d6934d68101ee2c2021-12-02T12:30:25ZCD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production10.1038/s41598-017-06397-42045-2322https://doaj.org/article/c2a3e62ec5e140ed9d6934d68101ee2c2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06397-4https://doaj.org/toc/2045-2322Abstract Eosinophils and their associated cytokines IL-4 and IL-5 are emerging as central orchestrators of the immune-metabolic axis. Herein, we demonstrate that cross-talk between the Ig-superfamily receptor CD300f and IL-5 is a key checkpoint that modifies the ability of eosinophils to regulate metabolic outcomes. Generation of Il5 Tg /Cd300f −/− mice revealed marked and distinct increases in eosinophil levels and their production of IL-4 in the white and brown adipose tissues. Consequently, Il5 Tg /Cd300f −/− mice had increased alternatively activated macrophage accumulation in the adipose tissue. Cd300f −/− mice displayed age-related accumulation of eosinophils and macrophages in the adipose tissue and decreased adipose tissue weight, which was associated with decreased diet-induced weight gain and insulin resistance. Notably, Il5 Tg /CD300f −/− were protected from diet-induced weight gain and glucose intolerance. These findings highlight the cross-talk between IL-5 receptor and CD300f as a novel pathway regulating adipose tissue eosinophils and offer new entry points for therapeutic intervention for obesity and its complications.Perri RozenbergHadar ReichmanIsrael Zab-BarMichal ItanMetsada Pasmanik-ChorCarine BouffiUdi QimronIdo BacheletPatricia C. FulkersonMarc E. RothenbergAriel MunitzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Perri Rozenberg Hadar Reichman Israel Zab-Bar Michal Itan Metsada Pasmanik-Chor Carine Bouffi Udi Qimron Ido Bachelet Patricia C. Fulkerson Marc E. Rothenberg Ariel Munitz CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production
description	Abstract Eosinophils and their associated cytokines IL-4 and IL-5 are emerging as central orchestrators of the immune-metabolic axis. Herein, we demonstrate that cross-talk between the Ig-superfamily receptor CD300f and IL-5 is a key checkpoint that modifies the ability of eosinophils to regulate metabolic outcomes. Generation of Il5 Tg /Cd300f −/− mice revealed marked and distinct increases in eosinophil levels and their production of IL-4 in the white and brown adipose tissues. Consequently, Il5 Tg /Cd300f −/− mice had increased alternatively activated macrophage accumulation in the adipose tissue. Cd300f −/− mice displayed age-related accumulation of eosinophils and macrophages in the adipose tissue and decreased adipose tissue weight, which was associated with decreased diet-induced weight gain and insulin resistance. Notably, Il5 Tg /CD300f −/− were protected from diet-induced weight gain and glucose intolerance. These findings highlight the cross-talk between IL-5 receptor and CD300f as a novel pathway regulating adipose tissue eosinophils and offer new entry points for therapeutic intervention for obesity and its complications.
format	article
author	Perri Rozenberg Hadar Reichman Israel Zab-Bar Michal Itan Metsada Pasmanik-Chor Carine Bouffi Udi Qimron Ido Bachelet Patricia C. Fulkerson Marc E. Rothenberg Ariel Munitz
author_facet	Perri Rozenberg Hadar Reichman Israel Zab-Bar Michal Itan Metsada Pasmanik-Chor Carine Bouffi Udi Qimron Ido Bachelet Patricia C. Fulkerson Marc E. Rothenberg Ariel Munitz
author_sort	Perri Rozenberg
title	CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production
title_short	CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production
title_full	CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production
title_fullStr	CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production
title_full_unstemmed	CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production
title_sort	cd300f:il-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent il-4 production
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c2a3e62ec5e140ed9d6934d68101ee2c
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CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production

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