Atrial fibrillation is associated with increased risk of lethal ventricular arrhythmias

Abstract Atrial fibrillation (AF) is associated with various major adverse cardiac events such as ischemic stroke, heart failure, and increased overall mortality. However, its association with lethal ventricular arrhythmias such as ventricular tachycardia (VT), ventricular flutter (VFL), and ventric...

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Autores principales:	Yun Gi Kim, Yun Young Choi, Kyung-Do Han, Kyongjin Min, Ha Young Choi, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c2a7ab22db5045e194124e3bd98d162d
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spelling	oai:doaj.org-article:c2a7ab22db5045e194124e3bd98d162d2021-12-02T18:02:14ZAtrial fibrillation is associated with increased risk of lethal ventricular arrhythmias10.1038/s41598-021-97335-y2045-2322https://doaj.org/article/c2a7ab22db5045e194124e3bd98d162d2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97335-yhttps://doaj.org/toc/2045-2322Abstract Atrial fibrillation (AF) is associated with various major adverse cardiac events such as ischemic stroke, heart failure, and increased overall mortality. However, its association with lethal ventricular arrhythmias such as ventricular tachycardia (VT), ventricular flutter (VFL), and ventricular fibrillation (VF) is controversial. We conducted this study to determine whether AF can increase the risk of VT, VFL, and VF. We utilized the Korean National Health Insurance Service database for this nationwide population-based study. This study enrolled people who underwent a nationwide health screen in 2009 for whom clinical follow-up data were available until December 2018. Primary outcome endpoint was the occurrence of VT, VFL, or VF in people who were and were not diagnosed with new-onset AF in 2009. We analyzed a total of 9,751,705 people. In 2009, 12,689 people were diagnosed with new-onset AF (AF group). The incidence (events per 1000 person-years of follow-up) of VT, VFL, and VF was 2.472 and 0.282 in the AF and non-AF groups, respectively. After adjustment for covariates, new-onset AF was associated with 4.6-fold increased risk (p < 0.001) of VT, VFL, and VF over 10 years of follow-up. The risk of VT, VFL, and VF was even higher if identification of AF was based on intensified criteria (≥ 2 outpatient records or ≥ 1 inpatient record; hazard ratio = 5.221; p < 0.001). In conclusion, the incidence of VT, VFL, and VF was significantly increased in people with new-onset AF. The potential risk of suffering lethal ventricular arrhythmia in people with AF should be considered in clinical practice.Yun Gi KimYun Young ChoiKyung-Do HanKyongjin MinHa Young ChoiJaemin ShimJong-Il ChoiYoung-Hoon KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yun Gi Kim Yun Young Choi Kyung-Do Han Kyongjin Min Ha Young Choi Jaemin Shim Jong-Il Choi Young-Hoon Kim Atrial fibrillation is associated with increased risk of lethal ventricular arrhythmias
description	Abstract Atrial fibrillation (AF) is associated with various major adverse cardiac events such as ischemic stroke, heart failure, and increased overall mortality. However, its association with lethal ventricular arrhythmias such as ventricular tachycardia (VT), ventricular flutter (VFL), and ventricular fibrillation (VF) is controversial. We conducted this study to determine whether AF can increase the risk of VT, VFL, and VF. We utilized the Korean National Health Insurance Service database for this nationwide population-based study. This study enrolled people who underwent a nationwide health screen in 2009 for whom clinical follow-up data were available until December 2018. Primary outcome endpoint was the occurrence of VT, VFL, or VF in people who were and were not diagnosed with new-onset AF in 2009. We analyzed a total of 9,751,705 people. In 2009, 12,689 people were diagnosed with new-onset AF (AF group). The incidence (events per 1000 person-years of follow-up) of VT, VFL, and VF was 2.472 and 0.282 in the AF and non-AF groups, respectively. After adjustment for covariates, new-onset AF was associated with 4.6-fold increased risk (p < 0.001) of VT, VFL, and VF over 10 years of follow-up. The risk of VT, VFL, and VF was even higher if identification of AF was based on intensified criteria (≥ 2 outpatient records or ≥ 1 inpatient record; hazard ratio = 5.221; p < 0.001). In conclusion, the incidence of VT, VFL, and VF was significantly increased in people with new-onset AF. The potential risk of suffering lethal ventricular arrhythmia in people with AF should be considered in clinical practice.
format	article
author	Yun Gi Kim Yun Young Choi Kyung-Do Han Kyongjin Min Ha Young Choi Jaemin Shim Jong-Il Choi Young-Hoon Kim
author_facet	Yun Gi Kim Yun Young Choi Kyung-Do Han Kyongjin Min Ha Young Choi Jaemin Shim Jong-Il Choi Young-Hoon Kim
author_sort	Yun Gi Kim
title	Atrial fibrillation is associated with increased risk of lethal ventricular arrhythmias
title_short	Atrial fibrillation is associated with increased risk of lethal ventricular arrhythmias
title_full	Atrial fibrillation is associated with increased risk of lethal ventricular arrhythmias
title_fullStr	Atrial fibrillation is associated with increased risk of lethal ventricular arrhythmias
title_full_unstemmed	Atrial fibrillation is associated with increased risk of lethal ventricular arrhythmias
title_sort	atrial fibrillation is associated with increased risk of lethal ventricular arrhythmias
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c2a7ab22db5045e194124e3bd98d162d
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Atrial fibrillation is associated with increased risk of lethal ventricular arrhythmias

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