The WT1-like transcription factor Klumpfuss maintains lineage commitment of enterocyte progenitors in the Drosophila intestine

Notch signaling mediates intestinal enteroblast specification in Drosophila but the molecular mechanism as to how this is regulated is unclear. Here, the authors show that the transcription factor Klumpfuss ensures enteroblast commitment through repression of enteroendocrine cell fate downstream of...

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Main Authors:	Jerome Korzelius, Sina Azami, Tal Ronnen-Oron, Philipp Koch, Maik Baldauf, Elke Meier, Imilce A. Rodriguez-Fernandez, Marco Groth, Pedro Sousa-Victor, Heinrich Jasper
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/c2a85d6a3b0f4b718c076a9ad8d66543
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spelling	oai:doaj.org-article:c2a85d6a3b0f4b718c076a9ad8d665432021-12-02T15:35:08ZThe WT1-like transcription factor Klumpfuss maintains lineage commitment of enterocyte progenitors in the Drosophila intestine10.1038/s41467-019-12003-02041-1723https://doaj.org/article/c2a85d6a3b0f4b718c076a9ad8d665432019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12003-0https://doaj.org/toc/2041-1723Notch signaling mediates intestinal enteroblast specification in Drosophila but the molecular mechanism as to how this is regulated is unclear. Here, the authors show that the transcription factor Klumpfuss ensures enteroblast commitment through repression of enteroendocrine cell fate downstream of Notch.Jerome KorzeliusSina AzamiTal Ronnen-OronPhilipp KochMaik BaldaufElke MeierImilce A. Rodriguez-FernandezMarco GrothPedro Sousa-VictorHeinrich JasperNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jerome Korzelius Sina Azami Tal Ronnen-Oron Philipp Koch Maik Baldauf Elke Meier Imilce A. Rodriguez-Fernandez Marco Groth Pedro Sousa-Victor Heinrich Jasper The WT1-like transcription factor Klumpfuss maintains lineage commitment of enterocyte progenitors in the Drosophila intestine
description	Notch signaling mediates intestinal enteroblast specification in Drosophila but the molecular mechanism as to how this is regulated is unclear. Here, the authors show that the transcription factor Klumpfuss ensures enteroblast commitment through repression of enteroendocrine cell fate downstream of Notch.
format	article
author	Jerome Korzelius Sina Azami Tal Ronnen-Oron Philipp Koch Maik Baldauf Elke Meier Imilce A. Rodriguez-Fernandez Marco Groth Pedro Sousa-Victor Heinrich Jasper
author_facet	Jerome Korzelius Sina Azami Tal Ronnen-Oron Philipp Koch Maik Baldauf Elke Meier Imilce A. Rodriguez-Fernandez Marco Groth Pedro Sousa-Victor Heinrich Jasper
author_sort	Jerome Korzelius
title	The WT1-like transcription factor Klumpfuss maintains lineage commitment of enterocyte progenitors in the Drosophila intestine
title_short	The WT1-like transcription factor Klumpfuss maintains lineage commitment of enterocyte progenitors in the Drosophila intestine
title_full	The WT1-like transcription factor Klumpfuss maintains lineage commitment of enterocyte progenitors in the Drosophila intestine
title_fullStr	The WT1-like transcription factor Klumpfuss maintains lineage commitment of enterocyte progenitors in the Drosophila intestine
title_full_unstemmed	The WT1-like transcription factor Klumpfuss maintains lineage commitment of enterocyte progenitors in the Drosophila intestine
title_sort	wt1-like transcription factor klumpfuss maintains lineage commitment of enterocyte progenitors in the drosophila intestine
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c2a85d6a3b0f4b718c076a9ad8d66543
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The WT1-like transcription factor Klumpfuss maintains lineage commitment of enterocyte progenitors in the Drosophila intestine

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