Combinations of alcohol-induced flushing with genetic polymorphisms of alcohol and aldehyde dehydrogenases and the risk of alcohol dependence in Japanese men and women.

<h4>Objective</h4>The risk of alcohol dependence (AD) in Japanese men and women was evaluated according to combinations of alcohol flushing and aldehyde dehydrogenase-2 (ALDH2, rs671) and alcohol dehydrogenase-1B (ADH1B, rs1229984) genotypes, all of which are known to determine AD suscep...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Akira Yokoyama, Tetsuji Yokoyama, Mitsuru Kimura, Sachio Matsushita, Masako Yokoyama
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c2a9371368e9436f9944e30088e0518b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c2a9371368e9436f9944e30088e0518b
record_format	dspace
spelling	oai:doaj.org-article:c2a9371368e9436f9944e30088e0518b2021-12-02T20:06:26ZCombinations of alcohol-induced flushing with genetic polymorphisms of alcohol and aldehyde dehydrogenases and the risk of alcohol dependence in Japanese men and women.1932-620310.1371/journal.pone.0255276https://doaj.org/article/c2a9371368e9436f9944e30088e0518b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255276https://doaj.org/toc/1932-6203<h4>Objective</h4>The risk of alcohol dependence (AD) in Japanese men and women was evaluated according to combinations of alcohol flushing and aldehyde dehydrogenase-2 (ALDH2, rs671) and alcohol dehydrogenase-1B (ADH1B, rs1229984) genotypes, all of which are known to determine AD susceptibility in Asians. Previous studies have focused on men, since women account for a smaller proportion of AD subjects.<h4>Methods</h4>Case control studies were conducted between 3721 male and 335 female AD Japanese and 610 male and 406 female controls who were asked about their current or former tendency to experience facial flushing after drinking a glass of beer and underwent ALDH2 and ADH1B genotyping. The time at which alcohol-induced facial flushing tendencies had disappeared in former-flushing AD subjects was also evaluated.<h4>Results</h4>Current alcohol flushing, the inactive ALDH21/2 genotype, and the fast-metabolizing ADH1B*2 allele were less frequently found in the AD groups. Although alcohol flushing was strongly influenced by the ALDH2 and ADH1B genotypes, multiple logistic model showed that never or former flushing and the genotype combinations were independent strong risk factors of AD in men and women. Never or former flushing (vs. current flushing) markedly increased the odds ratios of AD in carriers of each of the ALDH2 and ADH1B genotype combinations. The temporal profiles for drinking and flushing in former-flushing AD subjects revealed that the flushing response disappeared soon after or before the start of habitual drinking during young adulthood, regardless of the ALDH2 genotype.<h4>Conclusion</h4>Although alcohol flushing is influenced by the ALDH2 and ADH1B genotypes, constitutional or acquired flushing tolerance is an independent susceptibility trait for AD. The combination of the alcohol flushing status and the ALDH2 and ADH1B genotypes can provide a better new strategy for AD risk assessment than the alcohol flushing status alone or the genotypes alone in Asian men and women.Akira YokoyamaTetsuji YokoyamaMitsuru KimuraSachio MatsushitaMasako YokoyamaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0255276 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Akira Yokoyama Tetsuji Yokoyama Mitsuru Kimura Sachio Matsushita Masako Yokoyama Combinations of alcohol-induced flushing with genetic polymorphisms of alcohol and aldehyde dehydrogenases and the risk of alcohol dependence in Japanese men and women.
description	<h4>Objective</h4>The risk of alcohol dependence (AD) in Japanese men and women was evaluated according to combinations of alcohol flushing and aldehyde dehydrogenase-2 (ALDH2, rs671) and alcohol dehydrogenase-1B (ADH1B, rs1229984) genotypes, all of which are known to determine AD susceptibility in Asians. Previous studies have focused on men, since women account for a smaller proportion of AD subjects.<h4>Methods</h4>Case control studies were conducted between 3721 male and 335 female AD Japanese and 610 male and 406 female controls who were asked about their current or former tendency to experience facial flushing after drinking a glass of beer and underwent ALDH2 and ADH1B genotyping. The time at which alcohol-induced facial flushing tendencies had disappeared in former-flushing AD subjects was also evaluated.<h4>Results</h4>Current alcohol flushing, the inactive ALDH21/2 genotype, and the fast-metabolizing ADH1B*2 allele were less frequently found in the AD groups. Although alcohol flushing was strongly influenced by the ALDH2 and ADH1B genotypes, multiple logistic model showed that never or former flushing and the genotype combinations were independent strong risk factors of AD in men and women. Never or former flushing (vs. current flushing) markedly increased the odds ratios of AD in carriers of each of the ALDH2 and ADH1B genotype combinations. The temporal profiles for drinking and flushing in former-flushing AD subjects revealed that the flushing response disappeared soon after or before the start of habitual drinking during young adulthood, regardless of the ALDH2 genotype.<h4>Conclusion</h4>Although alcohol flushing is influenced by the ALDH2 and ADH1B genotypes, constitutional or acquired flushing tolerance is an independent susceptibility trait for AD. The combination of the alcohol flushing status and the ALDH2 and ADH1B genotypes can provide a better new strategy for AD risk assessment than the alcohol flushing status alone or the genotypes alone in Asian men and women.
format	article
author	Akira Yokoyama Tetsuji Yokoyama Mitsuru Kimura Sachio Matsushita Masako Yokoyama
author_facet	Akira Yokoyama Tetsuji Yokoyama Mitsuru Kimura Sachio Matsushita Masako Yokoyama
author_sort	Akira Yokoyama
title	Combinations of alcohol-induced flushing with genetic polymorphisms of alcohol and aldehyde dehydrogenases and the risk of alcohol dependence in Japanese men and women.
title_short	Combinations of alcohol-induced flushing with genetic polymorphisms of alcohol and aldehyde dehydrogenases and the risk of alcohol dependence in Japanese men and women.
title_full	Combinations of alcohol-induced flushing with genetic polymorphisms of alcohol and aldehyde dehydrogenases and the risk of alcohol dependence in Japanese men and women.
title_fullStr	Combinations of alcohol-induced flushing with genetic polymorphisms of alcohol and aldehyde dehydrogenases and the risk of alcohol dependence in Japanese men and women.
title_full_unstemmed	Combinations of alcohol-induced flushing with genetic polymorphisms of alcohol and aldehyde dehydrogenases and the risk of alcohol dependence in Japanese men and women.
title_sort	combinations of alcohol-induced flushing with genetic polymorphisms of alcohol and aldehyde dehydrogenases and the risk of alcohol dependence in japanese men and women.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c2a9371368e9436f9944e30088e0518b
work_keys_str_mv	AT akirayokoyama combinationsofalcoholinducedflushingwithgeneticpolymorphismsofalcoholandaldehydedehydrogenasesandtheriskofalcoholdependenceinjapanesemenandwomen AT tetsujiyokoyama combinationsofalcoholinducedflushingwithgeneticpolymorphismsofalcoholandaldehydedehydrogenasesandtheriskofalcoholdependenceinjapanesemenandwomen AT mitsurukimura combinationsofalcoholinducedflushingwithgeneticpolymorphismsofalcoholandaldehydedehydrogenasesandtheriskofalcoholdependenceinjapanesemenandwomen AT sachiomatsushita combinationsofalcoholinducedflushingwithgeneticpolymorphismsofalcoholandaldehydedehydrogenasesandtheriskofalcoholdependenceinjapanesemenandwomen AT masakoyokoyama combinationsofalcoholinducedflushingwithgeneticpolymorphismsofalcoholandaldehydedehydrogenasesandtheriskofalcoholdependenceinjapanesemenandwomen
_version_	1718375386483523584

Combinations of alcohol-induced flushing with genetic polymorphisms of alcohol and aldehyde dehydrogenases and the risk of alcohol dependence in Japanese men and women.

Ejemplares similares