Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer

Resistance to Herceptin represents a major challenge for successful treatment of HER2-positive breast cancer. Here, the authors demonstrate that the activation of the IGF2/IRS1 signal caused by disruption of a negative feedback loop between FOXO3a-miR-128/miR-30/miR-193 induces Herceptin resistance.

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Autores principales:	Liyun Luo, Zhijie Zhang, Ni Qiu, Li Ling, Xiaoting Jia, Ying Song, Hongsheng Li, Jiansheng Li, Hui Lyu, Hao Liu, Zhimin He, Bolin Liu, Guopei Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c2ab2374f4c049a490b02ad183f4c03c
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spelling	oai:doaj.org-article:c2ab2374f4c049a490b02ad183f4c03c2021-12-02T15:36:11ZDisruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer10.1038/s41467-021-23052-92041-1723https://doaj.org/article/c2ab2374f4c049a490b02ad183f4c03c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23052-9https://doaj.org/toc/2041-1723Resistance to Herceptin represents a major challenge for successful treatment of HER2-positive breast cancer. Here, the authors demonstrate that the activation of the IGF2/IRS1 signal caused by disruption of a negative feedback loop between FOXO3a-miR-128/miR-30/miR-193 induces Herceptin resistance.Liyun LuoZhijie ZhangNi QiuLi LingXiaoting JiaYing SongHongsheng LiJiansheng LiHui LyuHao LiuZhimin HeBolin LiuGuopei ZhengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liyun Luo Zhijie Zhang Ni Qiu Li Ling Xiaoting Jia Ying Song Hongsheng Li Jiansheng Li Hui Lyu Hao Liu Zhimin He Bolin Liu Guopei Zheng Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer
description	Resistance to Herceptin represents a major challenge for successful treatment of HER2-positive breast cancer. Here, the authors demonstrate that the activation of the IGF2/IRS1 signal caused by disruption of a negative feedback loop between FOXO3a-miR-128/miR-30/miR-193 induces Herceptin resistance.
format	article
author	Liyun Luo Zhijie Zhang Ni Qiu Li Ling Xiaoting Jia Ying Song Hongsheng Li Jiansheng Li Hui Lyu Hao Liu Zhimin He Bolin Liu Guopei Zheng
author_facet	Liyun Luo Zhijie Zhang Ni Qiu Li Ling Xiaoting Jia Ying Song Hongsheng Li Jiansheng Li Hui Lyu Hao Liu Zhimin He Bolin Liu Guopei Zheng
author_sort	Liyun Luo
title	Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer
title_short	Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer
title_full	Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer
title_fullStr	Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer
title_full_unstemmed	Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer
title_sort	disruption of foxo3a-mirna feedback inhibition of igf2/igf-1r/irs1 signaling confers herceptin resistance in her2-positive breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c2ab2374f4c049a490b02ad183f4c03c
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Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer

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