IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques

Infection of African green monkeys with SIV is associated with reduced pathogenicity. Here the authors explore the requirement of differentiated NK cell populations in a pathogenic Rhesus macaque model of SIV infection and show administration of IL-21 and IFNα rescues terminally differentiated NK ce...

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Autores principales:	Justin Harper, Nicolas Huot, Luca Micci, Gregory Tharp, Colin King, Philippe Rascle, Neeta Shenvi, Hong Wang, Cristin Galardi, Amit A. Upadhyay, Francois Villinger, Jeffrey Lifson, Guido Silvestri, Kirk Easley, Beatrice Jacquelin, Steven Bosinger, Michaela Müller-Trutwin, Mirko Paiardini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c2ab2bb398384c18b3ef628de01ccc2b
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spelling	oai:doaj.org-article:c2ab2bb398384c18b3ef628de01ccc2b2021-12-02T16:51:29ZIL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques10.1038/s41467-021-23189-72041-1723https://doaj.org/article/c2ab2bb398384c18b3ef628de01ccc2b2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23189-7https://doaj.org/toc/2041-1723Infection of African green monkeys with SIV is associated with reduced pathogenicity. Here the authors explore the requirement of differentiated NK cell populations in a pathogenic Rhesus macaque model of SIV infection and show administration of IL-21 and IFNα rescues terminally differentiated NK cells, similarly to what found in African green monkeys, and limits the SIV reservoir in antiretroviral therapy treated macaques.Justin HarperNicolas HuotLuca MicciGregory TharpColin KingPhilippe RascleNeeta ShenviHong WangCristin GalardiAmit A. UpadhyayFrancois VillingerJeffrey LifsonGuido SilvestriKirk EasleyBeatrice JacquelinSteven BosingerMichaela Müller-TrutwinMirko PaiardiniNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Justin Harper Nicolas Huot Luca Micci Gregory Tharp Colin King Philippe Rascle Neeta Shenvi Hong Wang Cristin Galardi Amit A. Upadhyay Francois Villinger Jeffrey Lifson Guido Silvestri Kirk Easley Beatrice Jacquelin Steven Bosinger Michaela Müller-Trutwin Mirko Paiardini IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques
description	Infection of African green monkeys with SIV is associated with reduced pathogenicity. Here the authors explore the requirement of differentiated NK cell populations in a pathogenic Rhesus macaque model of SIV infection and show administration of IL-21 and IFNα rescues terminally differentiated NK cells, similarly to what found in African green monkeys, and limits the SIV reservoir in antiretroviral therapy treated macaques.
format	article
author	Justin Harper Nicolas Huot Luca Micci Gregory Tharp Colin King Philippe Rascle Neeta Shenvi Hong Wang Cristin Galardi Amit A. Upadhyay Francois Villinger Jeffrey Lifson Guido Silvestri Kirk Easley Beatrice Jacquelin Steven Bosinger Michaela Müller-Trutwin Mirko Paiardini
author_facet	Justin Harper Nicolas Huot Luca Micci Gregory Tharp Colin King Philippe Rascle Neeta Shenvi Hong Wang Cristin Galardi Amit A. Upadhyay Francois Villinger Jeffrey Lifson Guido Silvestri Kirk Easley Beatrice Jacquelin Steven Bosinger Michaela Müller-Trutwin Mirko Paiardini
author_sort	Justin Harper
title	IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques
title_short	IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques
title_full	IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques
title_fullStr	IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques
title_full_unstemmed	IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques
title_sort	il-21 and ifnα therapy rescues terminally differentiated nk cells and limits siv reservoir in art-treated macaques
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c2ab2bb398384c18b3ef628de01ccc2b
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IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques

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