Wound healing activity of Allium cepa L. bulbs in a second-degree burn wound model in Holtzman rats

Background: The bulb of Allium cepa Linnaeus (onion) is used in traditional medicine as an antidiabetic, antioxidant, antihypertensive, anti-inflammatory, and antihyperlipidemic, among others. The lack of information or little knowledge about the effects of Allium cepa L. on skin lesions, specifica...

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Autores principales:	Ana María Guevara-Vásquez, Carmen Marín-Tello
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2021
Materias:	Burn Allium cepa L Phytochemicals Burn healing Silver sulfadiazine Histology Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/c2ab3faabfb24fb6995e0e268babb3fb
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spelling	oai:doaj.org-article:c2ab3faabfb24fb6995e0e268babb3fb2021-12-02T19:37:11Z Wound healing activity of Allium cepa L. bulbs in a second-degree burn wound model in Holtzman rats10.17533/udea.vitae.v28n3a3457370121-40042145-2660https://doaj.org/article/c2ab3faabfb24fb6995e0e268babb3fb2021-08-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/345737https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 Background: The bulb of Allium cepa Linnaeus (onion) is used in traditional medicine as an antidiabetic, antioxidant, antihypertensive, anti-inflammatory, and antihyperlipidemic, among others. The lack of information or little knowledge about the effects of Allium cepa L. on skin lesions, specifically burn wounds, arouses interest in studying its effects on these skin disorders. Objective: This study assessed the wound healing activity of Allium cepa L. on second-degree burns induced in Holtzman rats. Method: Thirty-two albino rats were randomly distributed into four groups of 8 rats each, including the Healthy group, the Control group, the Experimental group (Allium cepa L.), and the Standard group (1% silver sulfadiazine). Burn wounds were induced, and topical treatments were performed daily for 21 days. The reduction of the burned body area (mm2) was determined during the experimental time. Albino rats were sacrificed with an excess of surgical anesthesia to obtain tissue samples for histopathological analysis. Results: Standard and experimental groups significantly reduced burned body area (p<0.01) compared to the control group. Histopathological studies showed hyperemic chorion in the Control group, fibroblasts, and collagen in the Standard group, and dermis composed of a reticular stratum of fibroblasts, collagen, and few blood vessels in the Experimental group. Conclusion: Allium cepa L. revealed wound-healing activity on burns induced in Holtzman rats and reduced the damage produced by burns. Ana María Guevara-VásquezCarmen Marín-TelloUniversidad de AntioquiaarticleBurnAllium cepa LPhytochemicalsBurn healingSilver sulfadiazineHistologyFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 28, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Burn Allium cepa L Phytochemicals Burn healing Silver sulfadiazine Histology Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Burn Allium cepa L Phytochemicals Burn healing Silver sulfadiazine Histology Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Ana María Guevara-Vásquez Carmen Marín-Tello Wound healing activity of Allium cepa L. bulbs in a second-degree burn wound model in Holtzman rats
description	Background: The bulb of Allium cepa Linnaeus (onion) is used in traditional medicine as an antidiabetic, antioxidant, antihypertensive, anti-inflammatory, and antihyperlipidemic, among others. The lack of information or little knowledge about the effects of Allium cepa L. on skin lesions, specifically burn wounds, arouses interest in studying its effects on these skin disorders. Objective: This study assessed the wound healing activity of Allium cepa L. on second-degree burns induced in Holtzman rats. Method: Thirty-two albino rats were randomly distributed into four groups of 8 rats each, including the Healthy group, the Control group, the Experimental group (Allium cepa L.), and the Standard group (1% silver sulfadiazine). Burn wounds were induced, and topical treatments were performed daily for 21 days. The reduction of the burned body area (mm2) was determined during the experimental time. Albino rats were sacrificed with an excess of surgical anesthesia to obtain tissue samples for histopathological analysis. Results: Standard and experimental groups significantly reduced burned body area (p<0.01) compared to the control group. Histopathological studies showed hyperemic chorion in the Control group, fibroblasts, and collagen in the Standard group, and dermis composed of a reticular stratum of fibroblasts, collagen, and few blood vessels in the Experimental group. Conclusion: Allium cepa L. revealed wound-healing activity on burns induced in Holtzman rats and reduced the damage produced by burns.
format	article
author	Ana María Guevara-Vásquez Carmen Marín-Tello
author_facet	Ana María Guevara-Vásquez Carmen Marín-Tello
author_sort	Ana María Guevara-Vásquez
title	Wound healing activity of Allium cepa L. bulbs in a second-degree burn wound model in Holtzman rats
title_short	Wound healing activity of Allium cepa L. bulbs in a second-degree burn wound model in Holtzman rats
title_full	Wound healing activity of Allium cepa L. bulbs in a second-degree burn wound model in Holtzman rats
title_fullStr	Wound healing activity of Allium cepa L. bulbs in a second-degree burn wound model in Holtzman rats
title_full_unstemmed	Wound healing activity of Allium cepa L. bulbs in a second-degree burn wound model in Holtzman rats
title_sort	wound healing activity of allium cepa l. bulbs in a second-degree burn wound model in holtzman rats
publisher	Universidad de Antioquia
publishDate	2021
url	https://doaj.org/article/c2ab3faabfb24fb6995e0e268babb3fb
work_keys_str_mv	AT anamariaguevaravasquez woundhealingactivityofalliumcepalbulbsinaseconddegreeburnwoundmodelinholtzmanrats AT carmenmarintello woundhealingactivityofalliumcepalbulbsinaseconddegreeburnwoundmodelinholtzmanrats
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Wound healing activity of Allium cepa L. bulbs in a second-degree burn wound model in Holtzman rats

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