Theory and simulations of condensin mediated loop extrusion in DNA

How chromosomes, which are polymers with nearly billion base pairs, are packaged in the restricted nuclear volume is not well understood. Here, the authors combine polymer physics, nonequilibrium fluctuation theorem, and simulations to quantitatively predict the force-dependent velocity and step-siz...

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Autores principales:	Ryota Takaki, Atreya Dey, Guang Shi, D. Thirumalai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c2acd25da64d4e2ca116bf75bc99129d
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spelling	oai:doaj.org-article:c2acd25da64d4e2ca116bf75bc99129d2021-12-02T17:13:18ZTheory and simulations of condensin mediated loop extrusion in DNA10.1038/s41467-021-26167-12041-1723https://doaj.org/article/c2acd25da64d4e2ca116bf75bc99129d2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26167-1https://doaj.org/toc/2041-1723How chromosomes, which are polymers with nearly billion base pairs, are packaged in the restricted nuclear volume is not well understood. Here, the authors combine polymer physics, nonequilibrium fluctuation theorem, and simulations to quantitatively predict the force-dependent velocity and step-size distribution of condensin, which facilitates the folding of chromosomes by loop extrusion.Ryota TakakiAtreya DeyGuang ShiD. ThirumalaiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ryota Takaki Atreya Dey Guang Shi D. Thirumalai Theory and simulations of condensin mediated loop extrusion in DNA
description	How chromosomes, which are polymers with nearly billion base pairs, are packaged in the restricted nuclear volume is not well understood. Here, the authors combine polymer physics, nonequilibrium fluctuation theorem, and simulations to quantitatively predict the force-dependent velocity and step-size distribution of condensin, which facilitates the folding of chromosomes by loop extrusion.
format	article
author	Ryota Takaki Atreya Dey Guang Shi D. Thirumalai
author_facet	Ryota Takaki Atreya Dey Guang Shi D. Thirumalai
author_sort	Ryota Takaki
title	Theory and simulations of condensin mediated loop extrusion in DNA
title_short	Theory and simulations of condensin mediated loop extrusion in DNA
title_full	Theory and simulations of condensin mediated loop extrusion in DNA
title_fullStr	Theory and simulations of condensin mediated loop extrusion in DNA
title_full_unstemmed	Theory and simulations of condensin mediated loop extrusion in DNA
title_sort	theory and simulations of condensin mediated loop extrusion in dna
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c2acd25da64d4e2ca116bf75bc99129d
work_keys_str_mv	AT ryotatakaki theoryandsimulationsofcondensinmediatedloopextrusionindna AT atreyadey theoryandsimulationsofcondensinmediatedloopextrusionindna AT guangshi theoryandsimulationsofcondensinmediatedloopextrusionindna AT dthirumalai theoryandsimulationsofcondensinmediatedloopextrusionindna
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Theory and simulations of condensin mediated loop extrusion in DNA

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