Theory and simulations of condensin mediated loop extrusion in DNA

How chromosomes, which are polymers with nearly billion base pairs, are packaged in the restricted nuclear volume is not well understood. Here, the authors combine polymer physics, nonequilibrium fluctuation theorem, and simulations to quantitatively predict the force-dependent velocity and step-siz...

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Autores principales: Ryota Takaki, Atreya Dey, Guang Shi, D. Thirumalai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c2acd25da64d4e2ca116bf75bc99129d
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