Guidelines for therapeutic drug monitoring of vancomycin: a systematic review.

<h4>Background and objective</h4>Despite the availability of clinical practice guidelines (CPGs) for therapeutic drug monitoring (TDM) of vancomycin, vancomycin serum concentrations still do not reach therapeutic concentrations in many patients. Thus, we sought to systematically review t...

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Autores principales:	Zhi-Kang Ye, Can Li, Suo-Di Zhai
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c2ad0a93630c40658edab2449ba7bef2
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spelling	oai:doaj.org-article:c2ad0a93630c40658edab2449ba7bef22021-11-18T08:15:35ZGuidelines for therapeutic drug monitoring of vancomycin: a systematic review.1932-620310.1371/journal.pone.0099044https://doaj.org/article/c2ad0a93630c40658edab2449ba7bef22014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24932495/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and objective</h4>Despite the availability of clinical practice guidelines (CPGs) for therapeutic drug monitoring (TDM) of vancomycin, vancomycin serum concentrations still do not reach therapeutic concentrations in many patients. Thus, we sought to systematically review the quality and consistency of recommendations for an international cohort of CPGs regarding vancomycin TDM.<h4>Methods</h4>PubMed, Embase, guidelines' websites and Google were searched for CPGs for vancomycin TDM. Two independent assessors rated the quality of each CPG using the Appraisal of Guidelines for Research & Evaluation II (AGREEII) instrument and data were independently extracted.<h4>Results</h4>Twelve guidelines were evaluated and the overall quality of guidelines for vancomycin TDM was moderate. The highest score was recorded in the domain of clarity of presentation, and the lowest score was recorded in the domain of rigor of development and stakeholder involvement. The specific recommendations for vancomycin TDM were moderately consistent and guidelines varied in trough concentration monitoring, frequency of TDM, and serum concentration targets.<h4>Conclusion</h4>The overall guideline quality for vancomycin TDM was not optimal and effort is needed to improve guideline quality, especially in the domain of rigor of development and stakeholder involvement.Zhi-Kang YeCan LiSuo-Di ZhaiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e99044 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhi-Kang Ye Can Li Suo-Di Zhai Guidelines for therapeutic drug monitoring of vancomycin: a systematic review.
description	<h4>Background and objective</h4>Despite the availability of clinical practice guidelines (CPGs) for therapeutic drug monitoring (TDM) of vancomycin, vancomycin serum concentrations still do not reach therapeutic concentrations in many patients. Thus, we sought to systematically review the quality and consistency of recommendations for an international cohort of CPGs regarding vancomycin TDM.<h4>Methods</h4>PubMed, Embase, guidelines' websites and Google were searched for CPGs for vancomycin TDM. Two independent assessors rated the quality of each CPG using the Appraisal of Guidelines for Research & Evaluation II (AGREEII) instrument and data were independently extracted.<h4>Results</h4>Twelve guidelines were evaluated and the overall quality of guidelines for vancomycin TDM was moderate. The highest score was recorded in the domain of clarity of presentation, and the lowest score was recorded in the domain of rigor of development and stakeholder involvement. The specific recommendations for vancomycin TDM were moderately consistent and guidelines varied in trough concentration monitoring, frequency of TDM, and serum concentration targets.<h4>Conclusion</h4>The overall guideline quality for vancomycin TDM was not optimal and effort is needed to improve guideline quality, especially in the domain of rigor of development and stakeholder involvement.
format	article
author	Zhi-Kang Ye Can Li Suo-Di Zhai
author_facet	Zhi-Kang Ye Can Li Suo-Di Zhai
author_sort	Zhi-Kang Ye
title	Guidelines for therapeutic drug monitoring of vancomycin: a systematic review.
title_short	Guidelines for therapeutic drug monitoring of vancomycin: a systematic review.
title_full	Guidelines for therapeutic drug monitoring of vancomycin: a systematic review.
title_fullStr	Guidelines for therapeutic drug monitoring of vancomycin: a systematic review.
title_full_unstemmed	Guidelines for therapeutic drug monitoring of vancomycin: a systematic review.
title_sort	guidelines for therapeutic drug monitoring of vancomycin: a systematic review.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/c2ad0a93630c40658edab2449ba7bef2
work_keys_str_mv	AT zhikangye guidelinesfortherapeuticdrugmonitoringofvancomycinasystematicreview AT canli guidelinesfortherapeuticdrugmonitoringofvancomycinasystematicreview AT suodizhai guidelinesfortherapeuticdrugmonitoringofvancomycinasystematicreview
_version_	1718422010157072384

Guidelines for therapeutic drug monitoring of vancomycin: a systematic review.

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