Lack of association between ACE I/D, NOS3 VNTR polymorphisms and drug toxicity of tacrolimus treated post-renal transplantation patients

Introduction: Tacrolimus is the most commonly used calcineurin inhibitor for renal transplant individuals. Genetic factors play a major role in allografts by affecting blood pressure regulation, vascular proliferation and inflammatory responses. Objectives: The aim of this study was to evaluate a po...

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Autores principales:	Kathulapali Krishna, Sanjana Satheesh, Gnanasambandan Ramanathan, Solomon F. D. Paul, Jayakumar Matcha, Ramprasad Elumalai
Formato:	article
Lenguaje:	EN
Publicado:	Society of Diabetic Nephropathy Prevention 2020
Materias:	tacrolimus ace i/d nos3 vntr transplantation polymorphisms end-stage renal disease calcineurin inhibitors Therapeutics. Pharmacology RM1-950 Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/c2aee2b67d304a198b3bb1d2667301e5
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spelling	oai:doaj.org-article:c2aee2b67d304a198b3bb1d2667301e52021-11-17T08:13:31ZLack of association between ACE I/D, NOS3 VNTR polymorphisms and drug toxicity of tacrolimus treated post-renal transplantation patients2345-420210.34172/npj.2020.19https://doaj.org/article/c2aee2b67d304a198b3bb1d2667301e52020-05-01T00:00:00Zhttps://jnephropharmacology.com/PDF/npj-4304https://doaj.org/toc/2345-4202Introduction: Tacrolimus is the most commonly used calcineurin inhibitor for renal transplant individuals. Genetic factors play a major role in allografts by affecting blood pressure regulation, vascular proliferation and inflammatory responses. Objectives: The aim of this study was to evaluate a possible role of the ACE I/D and NOS3 VNTR polymorphisms in kidney transplantation patients treated with tacrolimus in the south Indian population. Patients and Methods: This study included 50 kidney transplant individuals and 100 unrelated healthy individuals from the general population as control. The genotyping was performed by polymerase chain reaction and electrophoresis. Genotypes were compared among cases and controls applying χ2 test. The difference in C/D ratios was compared using Mann–Whitney U test or Kruskal-Wallis test. Results: The ACE ID polymorphisms in different models [genetic (P=0.723), dominant (P=0.148) and recessive (P=0.652)] or allele model (P=0.455) did not differ significantly between the groups. Similarly, there was no significant difference for the NOS3 VNTR genotypes in genetic model (bb vs ba P=0.118; bb vs aa P=0.446), dominant model (bb vs ba+aa P=0.099) and allelic model (b vs a P=0.103). No significant difference was observed for ACE ID and NOS3 VNTR genotypes between the toxicity and non-toxicity groups. Furthermore, no significant association was observed for daily dose and concentration dose ratio for the studied polymorphisms. Conclusion: The present study revealed no significant association between cases and controls as well as toxicity and non-toxicity groups. Furthermore, there was no association between genotypes and daily dose and dose concentration.Kathulapali KrishnaSanjana SatheeshGnanasambandan RamanathanSolomon F. D. PaulJayakumar MatchaRamprasad ElumalaiSociety of Diabetic Nephropathy Prevention articletacrolimusace i/dnos3 vntrtransplantationpolymorphismsend-stage renal diseasecalcineurin inhibitorsTherapeutics. PharmacologyRM1-950Diseases of the genitourinary system. UrologyRC870-923ENJournal of Nephropharmacology, Vol 9, Iss 2, Pp e19-e19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	tacrolimus ace i/d nos3 vntr transplantation polymorphisms end-stage renal disease calcineurin inhibitors Therapeutics. Pharmacology RM1-950 Diseases of the genitourinary system. Urology RC870-923
spellingShingle	tacrolimus ace i/d nos3 vntr transplantation polymorphisms end-stage renal disease calcineurin inhibitors Therapeutics. Pharmacology RM1-950 Diseases of the genitourinary system. Urology RC870-923 Kathulapali Krishna Sanjana Satheesh Gnanasambandan Ramanathan Solomon F. D. Paul Jayakumar Matcha Ramprasad Elumalai Lack of association between ACE I/D, NOS3 VNTR polymorphisms and drug toxicity of tacrolimus treated post-renal transplantation patients
description	Introduction: Tacrolimus is the most commonly used calcineurin inhibitor for renal transplant individuals. Genetic factors play a major role in allografts by affecting blood pressure regulation, vascular proliferation and inflammatory responses. Objectives: The aim of this study was to evaluate a possible role of the ACE I/D and NOS3 VNTR polymorphisms in kidney transplantation patients treated with tacrolimus in the south Indian population. Patients and Methods: This study included 50 kidney transplant individuals and 100 unrelated healthy individuals from the general population as control. The genotyping was performed by polymerase chain reaction and electrophoresis. Genotypes were compared among cases and controls applying χ2 test. The difference in C/D ratios was compared using Mann–Whitney U test or Kruskal-Wallis test. Results: The ACE ID polymorphisms in different models [genetic (P=0.723), dominant (P=0.148) and recessive (P=0.652)] or allele model (P=0.455) did not differ significantly between the groups. Similarly, there was no significant difference for the NOS3 VNTR genotypes in genetic model (bb vs ba P=0.118; bb vs aa P=0.446), dominant model (bb vs ba+aa P=0.099) and allelic model (b vs a P=0.103). No significant difference was observed for ACE ID and NOS3 VNTR genotypes between the toxicity and non-toxicity groups. Furthermore, no significant association was observed for daily dose and concentration dose ratio for the studied polymorphisms. Conclusion: The present study revealed no significant association between cases and controls as well as toxicity and non-toxicity groups. Furthermore, there was no association between genotypes and daily dose and dose concentration.
format	article
author	Kathulapali Krishna Sanjana Satheesh Gnanasambandan Ramanathan Solomon F. D. Paul Jayakumar Matcha Ramprasad Elumalai
author_facet	Kathulapali Krishna Sanjana Satheesh Gnanasambandan Ramanathan Solomon F. D. Paul Jayakumar Matcha Ramprasad Elumalai
author_sort	Kathulapali Krishna
title	Lack of association between ACE I/D, NOS3 VNTR polymorphisms and drug toxicity of tacrolimus treated post-renal transplantation patients
title_short	Lack of association between ACE I/D, NOS3 VNTR polymorphisms and drug toxicity of tacrolimus treated post-renal transplantation patients
title_full	Lack of association between ACE I/D, NOS3 VNTR polymorphisms and drug toxicity of tacrolimus treated post-renal transplantation patients
title_fullStr	Lack of association between ACE I/D, NOS3 VNTR polymorphisms and drug toxicity of tacrolimus treated post-renal transplantation patients
title_full_unstemmed	Lack of association between ACE I/D, NOS3 VNTR polymorphisms and drug toxicity of tacrolimus treated post-renal transplantation patients
title_sort	lack of association between ace i/d, nos3 vntr polymorphisms and drug toxicity of tacrolimus treated post-renal transplantation patients
publisher	Society of Diabetic Nephropathy Prevention
publishDate	2020
url	https://doaj.org/article/c2aee2b67d304a198b3bb1d2667301e5
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Lack of association between ACE I/D, NOS3 VNTR polymorphisms and drug toxicity of tacrolimus treated post-renal transplantation patients

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