Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging

It was recently shown that basal cells in pseudostratified epithelia extend a long cytoplasmic process across the tight junction barrier into the lumen. Here Roy & Kim et al. show that these projections, which they call axiopodia, extend and retract over time in a c-Src and MEK-ERK-dependent man...

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Autores principales: Jeremy Roy, Bongki Kim, Eric Hill, Pablo Visconti, Dario Krapf, Claudio Vinegoni, Ralph Weissleder, Dennis Brown, Sylvie Breton
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/c2b4a35c0b4d4e6a977b4fe35a92f98f
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Sumario:It was recently shown that basal cells in pseudostratified epithelia extend a long cytoplasmic process across the tight junction barrier into the lumen. Here Roy & Kim et al. show that these projections, which they call axiopodia, extend and retract over time in a c-Src and MEK-ERK-dependent manner.