BLEEDING MANAGEMENT DURING DELIVERY AND POSTPARTUM PERIOD IN GLANZMANN THROMBASTHENIA: EXPERIENCES FROM TWO CASES

Objective: Glanzmann thrombasthenia (GT) is a hereditary bleeding disorder. The platelets lack αIIbβ3integrin and fail to aggregate. Pregnancy can also lead to isoantibody formation when fetal cells with β3integrins pass into the circulation of a mother lacking them; a consequence is neonatal thromb...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Özden ÖZLÜK, Mustafa Murat ÖZBALAK, Tarık Onur TİRYAKİ, Sevgi KALAYOĞLU BEŞIŞIK, Tuba SARAÇ SİVRİKOZ
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/c2b4b3726a1445d88f9a5b5bd19c070b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c2b4b3726a1445d88f9a5b5bd19c070b
record_format	dspace
spelling	oai:doaj.org-article:c2b4b3726a1445d88f9a5b5bd19c070b2021-11-10T04:35:37ZBLEEDING MANAGEMENT DURING DELIVERY AND POSTPARTUM PERIOD IN GLANZMANN THROMBASTHENIA: EXPERIENCES FROM TWO CASES2531-137910.1016/j.htct.2021.10.1029https://doaj.org/article/c2b4b3726a1445d88f9a5b5bd19c070b2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137921011767https://doaj.org/toc/2531-1379Objective: Glanzmann thrombasthenia (GT) is a hereditary bleeding disorder. The platelets lack αIIbβ3integrin and fail to aggregate. Pregnancy can also lead to isoantibody formation when fetal cells with β3integrins pass into the circulation of a mother lacking them; a consequence is neonatal thrombocytopenia and a high risk of mortality. We here present our experience with two GT patients, in which rFVIIa was our choice for bleeding prophylaxis and/or control during delivery and postpartum period. Case report: Case 1: A 28-year-old woman with GT was hospitalized. She was on 38th gestational week (GW). Vaginal delivery was completed with rFVIIa prophylaxis. Postpartum 5th day rFVIIa stopped. The patient discharged with a minimal vaginal bleeding. Postpartum10th day, she developed severe bleeding. GT seemed to be the only related factor. rFVIIa restarted with tranexamic acid and misoprostol. Two apheresis units of platelets were transfused. That time, rFVIIa continued 7 days. Methodology: Case 2: A 26-year-old woman with GT developed hematuria on 30th GW. No urinary system pathology was found. With. rFVIIa treatment, hematuria was ceased. On 39th GW, during labor she developed massive bleeding. As urgent management, 8 random units of platelet and 5 units of packed red blood cell were transfused with local vaginal compress. rFVIIa treatment was initiated. On 10th days of rFIIa with minimal vaginal bleeding the patient was discharged from the hospital. Results: In both of the patients, no major neonatal bleeding problem was experienced. Conclusion: GT patients are at risk for heavy bleeding during labor, deliver or postpartum. Platelet transfusion is simple and easy option for bleeding control. In alloimmunized patients pooled platelet should be used. The use of rFVIIa appears to be safe and relatively effective.Özden ÖZLÜKMustafa Murat ÖZBALAKTarık Onur TİRYAKİSevgi KALAYOĞLU BEŞIŞIKTuba SARAÇ SİVRİKOZElsevierarticleDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S40- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Özden ÖZLÜK Mustafa Murat ÖZBALAK Tarık Onur TİRYAKİ Sevgi KALAYOĞLU BEŞIŞIK Tuba SARAÇ SİVRİKOZ BLEEDING MANAGEMENT DURING DELIVERY AND POSTPARTUM PERIOD IN GLANZMANN THROMBASTHENIA: EXPERIENCES FROM TWO CASES
description	Objective: Glanzmann thrombasthenia (GT) is a hereditary bleeding disorder. The platelets lack αIIbβ3integrin and fail to aggregate. Pregnancy can also lead to isoantibody formation when fetal cells with β3integrins pass into the circulation of a mother lacking them; a consequence is neonatal thrombocytopenia and a high risk of mortality. We here present our experience with two GT patients, in which rFVIIa was our choice for bleeding prophylaxis and/or control during delivery and postpartum period. Case report: Case 1: A 28-year-old woman with GT was hospitalized. She was on 38th gestational week (GW). Vaginal delivery was completed with rFVIIa prophylaxis. Postpartum 5th day rFVIIa stopped. The patient discharged with a minimal vaginal bleeding. Postpartum10th day, she developed severe bleeding. GT seemed to be the only related factor. rFVIIa restarted with tranexamic acid and misoprostol. Two apheresis units of platelets were transfused. That time, rFVIIa continued 7 days. Methodology: Case 2: A 26-year-old woman with GT developed hematuria on 30th GW. No urinary system pathology was found. With. rFVIIa treatment, hematuria was ceased. On 39th GW, during labor she developed massive bleeding. As urgent management, 8 random units of platelet and 5 units of packed red blood cell were transfused with local vaginal compress. rFVIIa treatment was initiated. On 10th days of rFIIa with minimal vaginal bleeding the patient was discharged from the hospital. Results: In both of the patients, no major neonatal bleeding problem was experienced. Conclusion: GT patients are at risk for heavy bleeding during labor, deliver or postpartum. Platelet transfusion is simple and easy option for bleeding control. In alloimmunized patients pooled platelet should be used. The use of rFVIIa appears to be safe and relatively effective.
format	article
author	Özden ÖZLÜK Mustafa Murat ÖZBALAK Tarık Onur TİRYAKİ Sevgi KALAYOĞLU BEŞIŞIK Tuba SARAÇ SİVRİKOZ
author_facet	Özden ÖZLÜK Mustafa Murat ÖZBALAK Tarık Onur TİRYAKİ Sevgi KALAYOĞLU BEŞIŞIK Tuba SARAÇ SİVRİKOZ
author_sort	Özden ÖZLÜK
title	BLEEDING MANAGEMENT DURING DELIVERY AND POSTPARTUM PERIOD IN GLANZMANN THROMBASTHENIA: EXPERIENCES FROM TWO CASES
title_short	BLEEDING MANAGEMENT DURING DELIVERY AND POSTPARTUM PERIOD IN GLANZMANN THROMBASTHENIA: EXPERIENCES FROM TWO CASES
title_full	BLEEDING MANAGEMENT DURING DELIVERY AND POSTPARTUM PERIOD IN GLANZMANN THROMBASTHENIA: EXPERIENCES FROM TWO CASES
title_fullStr	BLEEDING MANAGEMENT DURING DELIVERY AND POSTPARTUM PERIOD IN GLANZMANN THROMBASTHENIA: EXPERIENCES FROM TWO CASES
title_full_unstemmed	BLEEDING MANAGEMENT DURING DELIVERY AND POSTPARTUM PERIOD IN GLANZMANN THROMBASTHENIA: EXPERIENCES FROM TWO CASES
title_sort	bleeding management during delivery and postpartum period in glanzmann thrombasthenia: experiences from two cases
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c2b4b3726a1445d88f9a5b5bd19c070b
work_keys_str_mv	AT ozdenozluk bleedingmanagementduringdeliveryandpostpartumperiodinglanzmannthrombastheniaexperiencesfromtwocases AT mustafamuratozbalak bleedingmanagementduringdeliveryandpostpartumperiodinglanzmannthrombastheniaexperiencesfromtwocases AT tarıkonurtiryaki bleedingmanagementduringdeliveryandpostpartumperiodinglanzmannthrombastheniaexperiencesfromtwocases AT sevgikalayoglubesisik bleedingmanagementduringdeliveryandpostpartumperiodinglanzmannthrombastheniaexperiencesfromtwocases AT tubasaracsivrikoz bleedingmanagementduringdeliveryandpostpartumperiodinglanzmannthrombastheniaexperiencesfromtwocases
_version_	1718440595015335936

BLEEDING MANAGEMENT DURING DELIVERY AND POSTPARTUM PERIOD IN GLANZMANN THROMBASTHENIA: EXPERIENCES FROM TWO CASES

Ejemplares similares