Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study

<i>Background and Objectives:</i> Female reproductive hormones may affect core body temperature. This study aimed to investigate the effects of female reproductive hormones on inadvertent intraoperative hypothermia in patients who underwent laparoscopic gynecologic surgery under general...

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Autores principales:	Cheol Lee, SeongNam Park, ByoungRyun Kim, Hyeonbin Yim, Myeongjong Lee, Juhwan Lee, Hyungtae Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hypothermia gynecologic surgery reproductive hormones Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c2b9fb993ef64347bcc5bcf7670e7ede
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spelling	oai:doaj.org-article:c2b9fb993ef64347bcc5bcf7670e7ede2021-11-25T18:18:59ZEffects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study10.3390/medicina571112551648-91441010-660Xhttps://doaj.org/article/c2b9fb993ef64347bcc5bcf7670e7ede2021-11-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1255https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144<i>Background and Objectives:</i> Female reproductive hormones may affect core body temperature. This study aimed to investigate the effects of female reproductive hormones on inadvertent intraoperative hypothermia in patients who underwent laparoscopic gynecologic surgery under general anesthesia. <i>Materials and Methods:</i> This retrospective study included 660 menstruating and menopausal female patients aged 19–65 years. The patients were divided into two groups according to the occurrence of inadvertent intraoperative hypothermia: non-hypothermia group (<i>N</i> = 472) and hypothermia group (<i>N</i> = 188). After propensity score matching, 312 patients (<i>N</i> = 156 in each group) were analyzed to investigate the association between intraoperative hypothermia and female reproductive hormones. As potential predictors of inadvertent hypothermia, the levels of female reproductive hormones were analyzed using binary logistic regression. <i>Results:</i> The association of estradiol (r = −0.218, <i>p</i> = 0.000) and progesterone (r = −0.235, <i>p</i> = 0.000) levels with inadvertent intraoperative hypothermia was significant but weakly negative before matching; however, it was significant and moderately negative after matching (r = −0.326, <i>p</i> = 0.000 and r = −0.485, <i>p</i> = 0.000, respectively). In a binary logistic analysis, the odds ratio for estradiol was 0.995 (<i>p</i> = 0.014, 0.993 < 95% confidence interval [CI] < 0.998) before matching and 0.993 (<i>p</i> = 0.000, 0.862 < 95% CI < 0.930) after matching, and that for progesterone was 0.895 (<i>p</i> = 0.000, 0.862 < 95% CI < 0.930) before matching and 0.833 (<i>p</i> = 0.014, 0.990 < 95% CI < 0.996) after matching. <i>Conclusions:</i> Estradiol and progesterone levels were associated with inadvertent intraoperative hypothermia. However, the odds ratio for female reproductive hormone levels was close to 1. Therefore, female reproductive hormones may not be a risk factor for hypothermia during gynecologic surgery under general anesthesia. However, a small sample size in this study limits the generalizability of the results.Cheol LeeSeongNam ParkByoungRyun KimHyeonbin YimMyeongjong LeeJuhwan LeeHyungtae KimMDPI AGarticlehypothermiagynecologic surgeryreproductive hormonesMedicine (General)R5-920ENMedicina, Vol 57, Iss 1255, p 1255 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypothermia gynecologic surgery reproductive hormones Medicine (General) R5-920
spellingShingle	hypothermia gynecologic surgery reproductive hormones Medicine (General) R5-920 Cheol Lee SeongNam Park ByoungRyun Kim Hyeonbin Yim Myeongjong Lee Juhwan Lee Hyungtae Kim Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study
description	<i>Background and Objectives:</i> Female reproductive hormones may affect core body temperature. This study aimed to investigate the effects of female reproductive hormones on inadvertent intraoperative hypothermia in patients who underwent laparoscopic gynecologic surgery under general anesthesia. <i>Materials and Methods:</i> This retrospective study included 660 menstruating and menopausal female patients aged 19–65 years. The patients were divided into two groups according to the occurrence of inadvertent intraoperative hypothermia: non-hypothermia group (<i>N</i> = 472) and hypothermia group (<i>N</i> = 188). After propensity score matching, 312 patients (<i>N</i> = 156 in each group) were analyzed to investigate the association between intraoperative hypothermia and female reproductive hormones. As potential predictors of inadvertent hypothermia, the levels of female reproductive hormones were analyzed using binary logistic regression. <i>Results:</i> The association of estradiol (r = −0.218, <i>p</i> = 0.000) and progesterone (r = −0.235, <i>p</i> = 0.000) levels with inadvertent intraoperative hypothermia was significant but weakly negative before matching; however, it was significant and moderately negative after matching (r = −0.326, <i>p</i> = 0.000 and r = −0.485, <i>p</i> = 0.000, respectively). In a binary logistic analysis, the odds ratio for estradiol was 0.995 (<i>p</i> = 0.014, 0.993 < 95% confidence interval [CI] < 0.998) before matching and 0.993 (<i>p</i> = 0.000, 0.862 < 95% CI < 0.930) after matching, and that for progesterone was 0.895 (<i>p</i> = 0.000, 0.862 < 95% CI < 0.930) before matching and 0.833 (<i>p</i> = 0.014, 0.990 < 95% CI < 0.996) after matching. <i>Conclusions:</i> Estradiol and progesterone levels were associated with inadvertent intraoperative hypothermia. However, the odds ratio for female reproductive hormone levels was close to 1. Therefore, female reproductive hormones may not be a risk factor for hypothermia during gynecologic surgery under general anesthesia. However, a small sample size in this study limits the generalizability of the results.
format	article
author	Cheol Lee SeongNam Park ByoungRyun Kim Hyeonbin Yim Myeongjong Lee Juhwan Lee Hyungtae Kim
author_facet	Cheol Lee SeongNam Park ByoungRyun Kim Hyeonbin Yim Myeongjong Lee Juhwan Lee Hyungtae Kim
author_sort	Cheol Lee
title	Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study
title_short	Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study
title_full	Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study
title_fullStr	Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study
title_full_unstemmed	Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study
title_sort	effects of female reproductive hormone levels on inadvertent intraoperative hypothermia during laparoscopic gynecologic surgery: a retrospective study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c2b9fb993ef64347bcc5bcf7670e7ede
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Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study

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