The interaction between a sexually transferred steroid hormone and a female protein regulates oogenesis in the malaria mosquito Anopheles gambiae.

Molecular interactions between male and female factors during mating profoundly affect the reproductive behavior and physiology of female insects. In natural populations of the malaria mosquito Anopheles gambiae, blood-fed females direct nutritional resources towards oogenesis only when inseminated....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Francesco Baldini, Paolo Gabrieli, Adam South, Clarissa Valim, Francesca Mancini, Flaminia Catteruccia
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c2bcda9730854e70a751fd776a3df1e1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c2bcda9730854e70a751fd776a3df1e1
record_format	dspace
spelling	oai:doaj.org-article:c2bcda9730854e70a751fd776a3df1e12021-11-18T05:37:46ZThe interaction between a sexually transferred steroid hormone and a female protein regulates oogenesis in the malaria mosquito Anopheles gambiae.1544-91731545-788510.1371/journal.pbio.1001695https://doaj.org/article/c2bcda9730854e70a751fd776a3df1e12013-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24204210/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Molecular interactions between male and female factors during mating profoundly affect the reproductive behavior and physiology of female insects. In natural populations of the malaria mosquito Anopheles gambiae, blood-fed females direct nutritional resources towards oogenesis only when inseminated. Here we show that the mating-dependent pathway of egg development in these mosquitoes is regulated by the interaction between the steroid hormone 20-hydroxy-ecdysone (20E) transferred by males during copulation and a female Mating-Induced Stimulator of Oogenesis (MISO) protein. RNAi silencing of MISO abolishes the increase in oogenesis caused by mating in blood-fed females, causes a delay in oocyte development, and impairs the function of male-transferred 20E. Co-immunoprecipitation experiments show that MISO and 20E interact in the female reproductive tract. Moreover MISO expression after mating is induced by 20E via the Ecdysone Receptor, demonstrating a close cooperation between the two factors. Male-transferred 20E therefore acts as a mating signal that females translate into an increased investment in egg development via a MISO-dependent pathway. The identification of this male-female reproductive interaction offers novel opportunities for the control of mosquito populations that transmit malaria.Francesco BaldiniPaolo GabrieliAdam SouthClarissa ValimFrancesca ManciniFlaminia CatterucciaPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 11, Iss 10, p e1001695 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Francesco Baldini Paolo Gabrieli Adam South Clarissa Valim Francesca Mancini Flaminia Catteruccia The interaction between a sexually transferred steroid hormone and a female protein regulates oogenesis in the malaria mosquito Anopheles gambiae.
description	Molecular interactions between male and female factors during mating profoundly affect the reproductive behavior and physiology of female insects. In natural populations of the malaria mosquito Anopheles gambiae, blood-fed females direct nutritional resources towards oogenesis only when inseminated. Here we show that the mating-dependent pathway of egg development in these mosquitoes is regulated by the interaction between the steroid hormone 20-hydroxy-ecdysone (20E) transferred by males during copulation and a female Mating-Induced Stimulator of Oogenesis (MISO) protein. RNAi silencing of MISO abolishes the increase in oogenesis caused by mating in blood-fed females, causes a delay in oocyte development, and impairs the function of male-transferred 20E. Co-immunoprecipitation experiments show that MISO and 20E interact in the female reproductive tract. Moreover MISO expression after mating is induced by 20E via the Ecdysone Receptor, demonstrating a close cooperation between the two factors. Male-transferred 20E therefore acts as a mating signal that females translate into an increased investment in egg development via a MISO-dependent pathway. The identification of this male-female reproductive interaction offers novel opportunities for the control of mosquito populations that transmit malaria.
format	article
author	Francesco Baldini Paolo Gabrieli Adam South Clarissa Valim Francesca Mancini Flaminia Catteruccia
author_facet	Francesco Baldini Paolo Gabrieli Adam South Clarissa Valim Francesca Mancini Flaminia Catteruccia
author_sort	Francesco Baldini
title	The interaction between a sexually transferred steroid hormone and a female protein regulates oogenesis in the malaria mosquito Anopheles gambiae.
title_short	The interaction between a sexually transferred steroid hormone and a female protein regulates oogenesis in the malaria mosquito Anopheles gambiae.
title_full	The interaction between a sexually transferred steroid hormone and a female protein regulates oogenesis in the malaria mosquito Anopheles gambiae.
title_fullStr	The interaction between a sexually transferred steroid hormone and a female protein regulates oogenesis in the malaria mosquito Anopheles gambiae.
title_full_unstemmed	The interaction between a sexually transferred steroid hormone and a female protein regulates oogenesis in the malaria mosquito Anopheles gambiae.
title_sort	interaction between a sexually transferred steroid hormone and a female protein regulates oogenesis in the malaria mosquito anopheles gambiae.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/c2bcda9730854e70a751fd776a3df1e1
work_keys_str_mv	AT francescobaldini theinteractionbetweenasexuallytransferredsteroidhormoneandafemaleproteinregulatesoogenesisinthemalariamosquitoanophelesgambiae AT paologabrieli theinteractionbetweenasexuallytransferredsteroidhormoneandafemaleproteinregulatesoogenesisinthemalariamosquitoanophelesgambiae AT adamsouth theinteractionbetweenasexuallytransferredsteroidhormoneandafemaleproteinregulatesoogenesisinthemalariamosquitoanophelesgambiae AT clarissavalim theinteractionbetweenasexuallytransferredsteroidhormoneandafemaleproteinregulatesoogenesisinthemalariamosquitoanophelesgambiae AT francescamancini theinteractionbetweenasexuallytransferredsteroidhormoneandafemaleproteinregulatesoogenesisinthemalariamosquitoanophelesgambiae AT flaminiacatteruccia theinteractionbetweenasexuallytransferredsteroidhormoneandafemaleproteinregulatesoogenesisinthemalariamosquitoanophelesgambiae AT francescobaldini interactionbetweenasexuallytransferredsteroidhormoneandafemaleproteinregulatesoogenesisinthemalariamosquitoanophelesgambiae AT paologabrieli interactionbetweenasexuallytransferredsteroidhormoneandafemaleproteinregulatesoogenesisinthemalariamosquitoanophelesgambiae AT adamsouth interactionbetweenasexuallytransferredsteroidhormoneandafemaleproteinregulatesoogenesisinthemalariamosquitoanophelesgambiae AT clarissavalim interactionbetweenasexuallytransferredsteroidhormoneandafemaleproteinregulatesoogenesisinthemalariamosquitoanophelesgambiae AT francescamancini interactionbetweenasexuallytransferredsteroidhormoneandafemaleproteinregulatesoogenesisinthemalariamosquitoanophelesgambiae AT flaminiacatteruccia interactionbetweenasexuallytransferredsteroidhormoneandafemaleproteinregulatesoogenesisinthemalariamosquitoanophelesgambiae
_version_	1718424878299742208

The interaction between a sexually transferred steroid hormone and a female protein regulates oogenesis in the malaria mosquito Anopheles gambiae.

Ejemplares similares