Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra.
<h4>Rationale</h4>Low-grade inflammation and emphysema have been shown to be associated with an increased risk of lung cancer. However, the systemic inflammatory response in patients with emphysema is still unknown.<h4>Objective</h4>TO COMPARE THE PLASMA CYTOKINE PROFILES IN...
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2013
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oai:doaj.org-article:c2bd8e4dc3cc4fc688fa0329e2742b852021-11-18T07:50:29ZSmokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra.1932-620310.1371/journal.pone.0060260https://doaj.org/article/c2bd8e4dc3cc4fc688fa0329e2742b852013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23577098/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Rationale</h4>Low-grade inflammation and emphysema have been shown to be associated with an increased risk of lung cancer. However, the systemic inflammatory response in patients with emphysema is still unknown.<h4>Objective</h4>TO COMPARE THE PLASMA CYTOKINE PROFILES IN TWO GROUPS OF CURRENT OR FORMER SMOKERS WITHOUT AIRWAY OBSTRUCTION: a control group of individuals without computed tomography (CT) detected emphysema vs. a study group of individuals with CT detected emphysema.<h4>Methods</h4>Subjects underwent a chest CT, spirometry, and determination of EGF, IL-15, IL-1ra, IL-8, MCP-1, MIP-1β, TGFα, TNFα, and VEGF levels in plasma. Cytokine levels in each group were compared adjusting for confounding factors.<h4>Results</h4>160 current smokers and former smokers without airway obstruction participated in the study: 80 without emphysema and 80 subjects with emphysema. Adjusted group comparisons revealed significant reductions in EGF (-0.317, p = 0.01), IL-15 (-0.21, p = 0.01), IL-8 (-0.180, p = 0.02) and IL-1ra (-0.220, p = 0.03) in subjects with emphysema and normal spirometry.<h4>Conclusions</h4>Current or former smokers expressing a well-defined disease characteristic such as emphysema, has a specific plasma cytokine profile. This includes a decrease of cytokines mainly implicated in activation of apoptosis or decrease of immunosurveillance. This information should be taken into account when evaluated patients with tobacco respiratory diseases.Juan P de-TorresDavid BlancoAna B AlcaideLuis M SeijoGorka BastarrikaMaría José PajaresArrate Muñoz-BarrutiaCarlos Ortiz-de-SolorzanoRuben PioArantza CampoUsua MontesVictor SeguraJesús PueyoLuis M MontuengaJavier J ZuluetaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e60260 (2013) |
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Medicine R Science Q Juan P de-Torres David Blanco Ana B Alcaide Luis M Seijo Gorka Bastarrika María José Pajares Arrate Muñoz-Barrutia Carlos Ortiz-de-Solorzano Ruben Pio Arantza Campo Usua Montes Victor Segura Jesús Pueyo Luis M Montuenga Javier J Zulueta Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra. |
| description |
<h4>Rationale</h4>Low-grade inflammation and emphysema have been shown to be associated with an increased risk of lung cancer. However, the systemic inflammatory response in patients with emphysema is still unknown.<h4>Objective</h4>TO COMPARE THE PLASMA CYTOKINE PROFILES IN TWO GROUPS OF CURRENT OR FORMER SMOKERS WITHOUT AIRWAY OBSTRUCTION: a control group of individuals without computed tomography (CT) detected emphysema vs. a study group of individuals with CT detected emphysema.<h4>Methods</h4>Subjects underwent a chest CT, spirometry, and determination of EGF, IL-15, IL-1ra, IL-8, MCP-1, MIP-1β, TGFα, TNFα, and VEGF levels in plasma. Cytokine levels in each group were compared adjusting for confounding factors.<h4>Results</h4>160 current smokers and former smokers without airway obstruction participated in the study: 80 without emphysema and 80 subjects with emphysema. Adjusted group comparisons revealed significant reductions in EGF (-0.317, p = 0.01), IL-15 (-0.21, p = 0.01), IL-8 (-0.180, p = 0.02) and IL-1ra (-0.220, p = 0.03) in subjects with emphysema and normal spirometry.<h4>Conclusions</h4>Current or former smokers expressing a well-defined disease characteristic such as emphysema, has a specific plasma cytokine profile. This includes a decrease of cytokines mainly implicated in activation of apoptosis or decrease of immunosurveillance. This information should be taken into account when evaluated patients with tobacco respiratory diseases. |
| format |
article |
| author |
Juan P de-Torres David Blanco Ana B Alcaide Luis M Seijo Gorka Bastarrika María José Pajares Arrate Muñoz-Barrutia Carlos Ortiz-de-Solorzano Ruben Pio Arantza Campo Usua Montes Victor Segura Jesús Pueyo Luis M Montuenga Javier J Zulueta |
| author_facet |
Juan P de-Torres David Blanco Ana B Alcaide Luis M Seijo Gorka Bastarrika María José Pajares Arrate Muñoz-Barrutia Carlos Ortiz-de-Solorzano Ruben Pio Arantza Campo Usua Montes Victor Segura Jesús Pueyo Luis M Montuenga Javier J Zulueta |
| author_sort |
Juan P de-Torres |
| title |
Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra. |
| title_short |
Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra. |
| title_full |
Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra. |
| title_fullStr |
Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra. |
| title_full_unstemmed |
Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra. |
| title_sort |
smokers with ct detected emphysema and no airway obstruction have decreased plasma levels of egf, il-15, il-8 and il-1ra. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/c2bd8e4dc3cc4fc688fa0329e2742b85 |
| work_keys_str_mv |
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