Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

In multiple sclerosis (MS), antigen-presenting cells inducing cytotoxic T cell response against mature oligodendrocytes remain to be identified. Here the authors show that oligodendrocyte precursors cross-present antigen taken up from mature oligodendrocytes, and are targeted by cytotoxic T cells in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Leslie Kirby, Jing Jin, Jaime Gonzalez Cardona, Matthew D. Smith, Kyle A. Martin, Jingya Wang, Hayley Strasburger, Leyla Herbst, Maya Alexis, Jodi Karnell, Todd Davidson, Ranjan Dutta, Joan Goverman, Dwight Bergles, Peter A. Calabresi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c2bdb6f697aa4aefb31caee253b40c56
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c2bdb6f697aa4aefb31caee253b40c56
record_format	dspace
spelling	oai:doaj.org-article:c2bdb6f697aa4aefb31caee253b40c562021-12-02T16:58:17ZOligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination10.1038/s41467-019-11638-32041-1723https://doaj.org/article/c2bdb6f697aa4aefb31caee253b40c562019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11638-3https://doaj.org/toc/2041-1723In multiple sclerosis (MS), antigen-presenting cells inducing cytotoxic T cell response against mature oligodendrocytes remain to be identified. Here the authors show that oligodendrocyte precursors cross-present antigen taken up from mature oligodendrocytes, and are targeted by cytotoxic T cells in cell culture and in an animal model of MS.Leslie KirbyJing JinJaime Gonzalez CardonaMatthew D. SmithKyle A. MartinJingya WangHayley StrasburgerLeyla HerbstMaya AlexisJodi KarnellTodd DavidsonRanjan DuttaJoan GovermanDwight BerglesPeter A. CalabresiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leslie Kirby Jing Jin Jaime Gonzalez Cardona Matthew D. Smith Kyle A. Martin Jingya Wang Hayley Strasburger Leyla Herbst Maya Alexis Jodi Karnell Todd Davidson Ranjan Dutta Joan Goverman Dwight Bergles Peter A. Calabresi Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination
description	In multiple sclerosis (MS), antigen-presenting cells inducing cytotoxic T cell response against mature oligodendrocytes remain to be identified. Here the authors show that oligodendrocyte precursors cross-present antigen taken up from mature oligodendrocytes, and are targeted by cytotoxic T cells in cell culture and in an animal model of MS.
format	article
author	Leslie Kirby Jing Jin Jaime Gonzalez Cardona Matthew D. Smith Kyle A. Martin Jingya Wang Hayley Strasburger Leyla Herbst Maya Alexis Jodi Karnell Todd Davidson Ranjan Dutta Joan Goverman Dwight Bergles Peter A. Calabresi
author_facet	Leslie Kirby Jing Jin Jaime Gonzalez Cardona Matthew D. Smith Kyle A. Martin Jingya Wang Hayley Strasburger Leyla Herbst Maya Alexis Jodi Karnell Todd Davidson Ranjan Dutta Joan Goverman Dwight Bergles Peter A. Calabresi
author_sort	Leslie Kirby
title	Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination
title_short	Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination
title_full	Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination
title_fullStr	Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination
title_full_unstemmed	Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination
title_sort	oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c2bdb6f697aa4aefb31caee253b40c56
work_keys_str_mv	AT lesliekirby oligodendrocyteprecursorcellspresentantigenandarecytotoxictargetsininflammatorydemyelination AT jingjin oligodendrocyteprecursorcellspresentantigenandarecytotoxictargetsininflammatorydemyelination AT jaimegonzalezcardona oligodendrocyteprecursorcellspresentantigenandarecytotoxictargetsininflammatorydemyelination AT matthewdsmith oligodendrocyteprecursorcellspresentantigenandarecytotoxictargetsininflammatorydemyelination AT kyleamartin oligodendrocyteprecursorcellspresentantigenandarecytotoxictargetsininflammatorydemyelination AT jingyawang oligodendrocyteprecursorcellspresentantigenandarecytotoxictargetsininflammatorydemyelination AT hayleystrasburger oligodendrocyteprecursorcellspresentantigenandarecytotoxictargetsininflammatorydemyelination AT leylaherbst oligodendrocyteprecursorcellspresentantigenandarecytotoxictargetsininflammatorydemyelination AT mayaalexis oligodendrocyteprecursorcellspresentantigenandarecytotoxictargetsininflammatorydemyelination AT jodikarnell oligodendrocyteprecursorcellspresentantigenandarecytotoxictargetsininflammatorydemyelination AT todddavidson oligodendrocyteprecursorcellspresentantigenandarecytotoxictargetsininflammatorydemyelination AT ranjandutta oligodendrocyteprecursorcellspresentantigenandarecytotoxictargetsininflammatorydemyelination AT joangoverman oligodendrocyteprecursorcellspresentantigenandarecytotoxictargetsininflammatorydemyelination AT dwightbergles oligodendrocyteprecursorcellspresentantigenandarecytotoxictargetsininflammatorydemyelination AT peteracalabresi oligodendrocyteprecursorcellspresentantigenandarecytotoxictargetsininflammatorydemyelination
_version_	1718382354512216064

Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

Ejemplares similares