Pseudoboehmite as a drug delivery system for acyclovir

Abstract Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and it is indicated for the treatment and management of recurrent cold sores on the lips and face, genital herpes, among other diseases. The problem...

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Autores principales:	Renato Meneghetti Peres, Jéssica Maiara Leme Sousa, Mariana Oliva de Oliveira, Maura Vincenza Rossi, Rene Ramos de Oliveira, Nelson Batista de Lima, Ayrton Bernussi, Juliusz Warzywoda, Bruno Sarmento, Antonio Hortencio Munhoz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c2c6b9b5c16949c984dcb3a107312d1d
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spelling	oai:doaj.org-article:c2c6b9b5c16949c984dcb3a107312d1d2021-12-02T18:47:04ZPseudoboehmite as a drug delivery system for acyclovir10.1038/s41598-021-94325-y2045-2322https://doaj.org/article/c2c6b9b5c16949c984dcb3a107312d1d2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94325-yhttps://doaj.org/toc/2045-2322Abstract Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and it is indicated for the treatment and management of recurrent cold sores on the lips and face, genital herpes, among other diseases. The problem of the oral bioavailability of acyclovir is limited because of the low permeability across the gastrointestinal membrane. The use of nanoparticles of pseudoboehmite as a drug delivery system in vitro assays is a promising approach to further the permeability of acyclovir release. Here we report the synthesis of high purity pseudoboehmite from aluminium nitrate and ammonium hydroxide containing nanoparticles, using the sol–gel method, as a drug delivery system to improve the systemic bioavailability of acyclovir. The presence of pseudoboehmite nanoparticles were verified by infrared spectroscopy, transmission electron microscopy, and X-ray diffraction techniques. In vivo tests were performed with Wistar rats to compare the release of acyclovir, with and without the addition of pseudoboehmite. The administration of acyclovir with the addition of pseudoboehmite increased the drug content by 4.6 times in the plasma of Wistar rats after 4 h administration. We determined that the toxicity of pseudoboehmite is low up to 10 mg/mL, in gel and the dried pseudoboehmite nanoparticles.Renato Meneghetti PeresJéssica Maiara Leme SousaMariana Oliva de OliveiraMaura Vincenza RossiRene Ramos de OliveiraNelson Batista de LimaAyrton BernussiJuliusz WarzywodaBruno SarmentoAntonio Hortencio MunhozNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Renato Meneghetti Peres Jéssica Maiara Leme Sousa Mariana Oliva de Oliveira Maura Vincenza Rossi Rene Ramos de Oliveira Nelson Batista de Lima Ayrton Bernussi Juliusz Warzywoda Bruno Sarmento Antonio Hortencio Munhoz Pseudoboehmite as a drug delivery system for acyclovir
description	Abstract Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and it is indicated for the treatment and management of recurrent cold sores on the lips and face, genital herpes, among other diseases. The problem of the oral bioavailability of acyclovir is limited because of the low permeability across the gastrointestinal membrane. The use of nanoparticles of pseudoboehmite as a drug delivery system in vitro assays is a promising approach to further the permeability of acyclovir release. Here we report the synthesis of high purity pseudoboehmite from aluminium nitrate and ammonium hydroxide containing nanoparticles, using the sol–gel method, as a drug delivery system to improve the systemic bioavailability of acyclovir. The presence of pseudoboehmite nanoparticles were verified by infrared spectroscopy, transmission electron microscopy, and X-ray diffraction techniques. In vivo tests were performed with Wistar rats to compare the release of acyclovir, with and without the addition of pseudoboehmite. The administration of acyclovir with the addition of pseudoboehmite increased the drug content by 4.6 times in the plasma of Wistar rats after 4 h administration. We determined that the toxicity of pseudoboehmite is low up to 10 mg/mL, in gel and the dried pseudoboehmite nanoparticles.
format	article
author	Renato Meneghetti Peres Jéssica Maiara Leme Sousa Mariana Oliva de Oliveira Maura Vincenza Rossi Rene Ramos de Oliveira Nelson Batista de Lima Ayrton Bernussi Juliusz Warzywoda Bruno Sarmento Antonio Hortencio Munhoz
author_facet	Renato Meneghetti Peres Jéssica Maiara Leme Sousa Mariana Oliva de Oliveira Maura Vincenza Rossi Rene Ramos de Oliveira Nelson Batista de Lima Ayrton Bernussi Juliusz Warzywoda Bruno Sarmento Antonio Hortencio Munhoz
author_sort	Renato Meneghetti Peres
title	Pseudoboehmite as a drug delivery system for acyclovir
title_short	Pseudoboehmite as a drug delivery system for acyclovir
title_full	Pseudoboehmite as a drug delivery system for acyclovir
title_fullStr	Pseudoboehmite as a drug delivery system for acyclovir
title_full_unstemmed	Pseudoboehmite as a drug delivery system for acyclovir
title_sort	pseudoboehmite as a drug delivery system for acyclovir
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c2c6b9b5c16949c984dcb3a107312d1d
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Pseudoboehmite as a drug delivery system for acyclovir

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