The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion
Abstract The human ABC transporter ABCG2 (Breast Cancer Resistance Protein, BCRP) is implicated in anticancer resistance, in detoxification across barriers and linked to gout. Here, we generate a novel atomic model of ABCG2 using the crystal structure of ABCG5/G8. Extensive mutagenesis verifies the...
Enregistré dans:
| Auteurs principaux: | , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2017
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/c2c9f38203e64d76aa5b081be233b11c |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|