The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion
Abstract The human ABC transporter ABCG2 (Breast Cancer Resistance Protein, BCRP) is implicated in anticancer resistance, in detoxification across barriers and linked to gout. Here, we generate a novel atomic model of ABCG2 using the crystal structure of ABCG5/G8. Extensive mutagenesis verifies the...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2017
|
| Subjects: | |
| Online Access: | https://doaj.org/article/c2c9f38203e64d76aa5b081be233b11c |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|