DOM-mediated membrane retention of fluoroquinolone as revealed by fluorescence quenching properties

Abstract In this study, membrane filtration tests showed that the membrane rejection degree of difloxacin hydrochloride (DFHC) increased significantly in the presence of Suwannee River DOM or Aldrich humic acid (2–10 mg-C/L). Titration experiments showed that the excitation and emission of Peak R be...

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Autores principales:	Shuang Liang, Li Lu, Fangang Meng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c2cd9fddf8a9479ea0cc353c0b4394b6
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spelling	oai:doaj.org-article:c2cd9fddf8a9479ea0cc353c0b4394b62021-12-02T15:05:17ZDOM-mediated membrane retention of fluoroquinolone as revealed by fluorescence quenching properties10.1038/s41598-017-05635-z2045-2322https://doaj.org/article/c2cd9fddf8a9479ea0cc353c0b4394b62017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05635-zhttps://doaj.org/toc/2045-2322Abstract In this study, membrane filtration tests showed that the membrane rejection degree of difloxacin hydrochloride (DFHC) increased significantly in the presence of Suwannee River DOM or Aldrich humic acid (2–10 mg-C/L). Titration experiments showed that the excitation and emission of Peak R belonging to DFHC exhibited blue shifts by 5 nm and 10 nm, respectively, in the presence of DOM. The presence of DFHC can, in turn, lead to more significant overlapping of the fluorescence peaks of the Suwannee River DOM and Aldrich humic acid. The parallel factor analysis (PARAFAC) of the excitation-emission matrix (EEM) spectra can well decompose the components belonging to DFHC from the DOM + DFHC mixtures. The maximum fluorescence intensity (FI max) of the antibiotic-like component (C1) sharply decreased upon the initial addition of DOM. More specifically, the Aldrich humic acid showed a larger quenching effect on DFHC than the Suwannee River DOM. The stability constants (K M ) obtained by the Ryan and Weber model also corroborated that the Aldrich humic acid had a much higher binding stability (K M = 4.07 L/mg) than the Suwannee River DOM (K M = 0.86 L/mg). These results have great implications for our understanding of the membrane filtration behavior of trace contaminants in natural waters.Shuang LiangLi LuFangang MengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shuang Liang Li Lu Fangang Meng DOM-mediated membrane retention of fluoroquinolone as revealed by fluorescence quenching properties
description	Abstract In this study, membrane filtration tests showed that the membrane rejection degree of difloxacin hydrochloride (DFHC) increased significantly in the presence of Suwannee River DOM or Aldrich humic acid (2–10 mg-C/L). Titration experiments showed that the excitation and emission of Peak R belonging to DFHC exhibited blue shifts by 5 nm and 10 nm, respectively, in the presence of DOM. The presence of DFHC can, in turn, lead to more significant overlapping of the fluorescence peaks of the Suwannee River DOM and Aldrich humic acid. The parallel factor analysis (PARAFAC) of the excitation-emission matrix (EEM) spectra can well decompose the components belonging to DFHC from the DOM + DFHC mixtures. The maximum fluorescence intensity (FI max) of the antibiotic-like component (C1) sharply decreased upon the initial addition of DOM. More specifically, the Aldrich humic acid showed a larger quenching effect on DFHC than the Suwannee River DOM. The stability constants (K M ) obtained by the Ryan and Weber model also corroborated that the Aldrich humic acid had a much higher binding stability (K M = 4.07 L/mg) than the Suwannee River DOM (K M = 0.86 L/mg). These results have great implications for our understanding of the membrane filtration behavior of trace contaminants in natural waters.
format	article
author	Shuang Liang Li Lu Fangang Meng
author_facet	Shuang Liang Li Lu Fangang Meng
author_sort	Shuang Liang
title	DOM-mediated membrane retention of fluoroquinolone as revealed by fluorescence quenching properties
title_short	DOM-mediated membrane retention of fluoroquinolone as revealed by fluorescence quenching properties
title_full	DOM-mediated membrane retention of fluoroquinolone as revealed by fluorescence quenching properties
title_fullStr	DOM-mediated membrane retention of fluoroquinolone as revealed by fluorescence quenching properties
title_full_unstemmed	DOM-mediated membrane retention of fluoroquinolone as revealed by fluorescence quenching properties
title_sort	dom-mediated membrane retention of fluoroquinolone as revealed by fluorescence quenching properties
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c2cd9fddf8a9479ea0cc353c0b4394b6
work_keys_str_mv	AT shuangliang dommediatedmembraneretentionoffluoroquinoloneasrevealedbyfluorescencequenchingproperties AT lilu dommediatedmembraneretentionoffluoroquinoloneasrevealedbyfluorescencequenchingproperties AT fangangmeng dommediatedmembraneretentionoffluoroquinoloneasrevealedbyfluorescencequenchingproperties
_version_	1718388919984193536

DOM-mediated membrane retention of fluoroquinolone as revealed by fluorescence quenching properties

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