Bio-multifunctional noncovalent porphyrin functionalized carbon-based nanocomposite

Abstract Herein, in a one-pot method, the reduced graphene oxide layers with the assistance of multiwalled carbon nanotubes were decorated to provide a suitable space for the in situ growth of CoNi2S4, and the porphyrins were incorporated into the layers as well to increase the sensitivity of the pr...

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Autores principales:	Navid Rabiee, Mojtaba Bagherzadeh, Amir Mohammad Ghadiri, Yousef Fatahi, Nafiseh Baheiraei, Moein Safarkhani, Abdullah Aldhaher, Rassoul Dinarvand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c2d28a1a160f48ab9ade9956fc6f0c26
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spelling	oai:doaj.org-article:c2d28a1a160f48ab9ade9956fc6f0c262021-12-02T11:45:04ZBio-multifunctional noncovalent porphyrin functionalized carbon-based nanocomposite10.1038/s41598-021-86119-z2045-2322https://doaj.org/article/c2d28a1a160f48ab9ade9956fc6f0c262021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86119-zhttps://doaj.org/toc/2045-2322Abstract Herein, in a one-pot method, the reduced graphene oxide layers with the assistance of multiwalled carbon nanotubes were decorated to provide a suitable space for the in situ growth of CoNi2S4, and the porphyrins were incorporated into the layers as well to increase the sensitivity of the prepared nanostructure. The prepared nanocomposite can establish π–π interactions between the genetic material and on the surface of porphyrin rings. Also, hydrogen bonds between genetic domains and the porphyrin’ nitrogen and the surface hydroxyl groups are probable. Furthermore, the potential donor–acceptor relationship between the d7 transition metal, cobalt, and the genetic material provides a suitable way to increase the interaction and gene loading , and transfections. The reason for this phenomenon was optimized to increase the EGFP by up to 17.9%. Furthermore, the sensing ability of the nanocomposite towards H2O2 was investigated. In this regard, the limit of detection of the H2O2 obtained 10 µM. Also, the in situ biosensing ability in the HEK-293 and PC12 cell lines was evaluated by the addition of PMA. The nanocomposite showed the ability to detect the released H2O2 after adding the minimum amount of 120 ng/mL of the PMA.Navid RabieeMojtaba BagherzadehAmir Mohammad GhadiriYousef FatahiNafiseh BaheiraeiMoein SafarkhaniAbdullah AldhaherRassoul DinarvandNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Navid Rabiee Mojtaba Bagherzadeh Amir Mohammad Ghadiri Yousef Fatahi Nafiseh Baheiraei Moein Safarkhani Abdullah Aldhaher Rassoul Dinarvand Bio-multifunctional noncovalent porphyrin functionalized carbon-based nanocomposite
description	Abstract Herein, in a one-pot method, the reduced graphene oxide layers with the assistance of multiwalled carbon nanotubes were decorated to provide a suitable space for the in situ growth of CoNi2S4, and the porphyrins were incorporated into the layers as well to increase the sensitivity of the prepared nanostructure. The prepared nanocomposite can establish π–π interactions between the genetic material and on the surface of porphyrin rings. Also, hydrogen bonds between genetic domains and the porphyrin’ nitrogen and the surface hydroxyl groups are probable. Furthermore, the potential donor–acceptor relationship between the d7 transition metal, cobalt, and the genetic material provides a suitable way to increase the interaction and gene loading , and transfections. The reason for this phenomenon was optimized to increase the EGFP by up to 17.9%. Furthermore, the sensing ability of the nanocomposite towards H2O2 was investigated. In this regard, the limit of detection of the H2O2 obtained 10 µM. Also, the in situ biosensing ability in the HEK-293 and PC12 cell lines was evaluated by the addition of PMA. The nanocomposite showed the ability to detect the released H2O2 after adding the minimum amount of 120 ng/mL of the PMA.
format	article
author	Navid Rabiee Mojtaba Bagherzadeh Amir Mohammad Ghadiri Yousef Fatahi Nafiseh Baheiraei Moein Safarkhani Abdullah Aldhaher Rassoul Dinarvand
author_facet	Navid Rabiee Mojtaba Bagherzadeh Amir Mohammad Ghadiri Yousef Fatahi Nafiseh Baheiraei Moein Safarkhani Abdullah Aldhaher Rassoul Dinarvand
author_sort	Navid Rabiee
title	Bio-multifunctional noncovalent porphyrin functionalized carbon-based nanocomposite
title_short	Bio-multifunctional noncovalent porphyrin functionalized carbon-based nanocomposite
title_full	Bio-multifunctional noncovalent porphyrin functionalized carbon-based nanocomposite
title_fullStr	Bio-multifunctional noncovalent porphyrin functionalized carbon-based nanocomposite
title_full_unstemmed	Bio-multifunctional noncovalent porphyrin functionalized carbon-based nanocomposite
title_sort	bio-multifunctional noncovalent porphyrin functionalized carbon-based nanocomposite
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c2d28a1a160f48ab9ade9956fc6f0c26
work_keys_str_mv	AT navidrabiee biomultifunctionalnoncovalentporphyrinfunctionalizedcarbonbasednanocomposite AT mojtababagherzadeh biomultifunctionalnoncovalentporphyrinfunctionalizedcarbonbasednanocomposite AT amirmohammadghadiri biomultifunctionalnoncovalentporphyrinfunctionalizedcarbonbasednanocomposite AT youseffatahi biomultifunctionalnoncovalentporphyrinfunctionalizedcarbonbasednanocomposite AT nafisehbaheiraei biomultifunctionalnoncovalentporphyrinfunctionalizedcarbonbasednanocomposite AT moeinsafarkhani biomultifunctionalnoncovalentporphyrinfunctionalizedcarbonbasednanocomposite AT abdullahaldhaher biomultifunctionalnoncovalentporphyrinfunctionalizedcarbonbasednanocomposite AT rassouldinarvand biomultifunctionalnoncovalentporphyrinfunctionalizedcarbonbasednanocomposite
_version_	1718395307370217472

Bio-multifunctional noncovalent porphyrin functionalized carbon-based nanocomposite

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