IL-6, PF-4, sCD40 L, and homocysteine are associated with the radiological progression of cerebral small-vessel disease: a 2-year follow-up study

Jacek Staszewski,1 Renata Piusińska-Macoch,1 Bogdan Brodacki,1 Ewa Skrobowska,2 Adam Stępień1 1Clinic of Neurology, 2Department of Radiology, Military Institute of Medicine, Warsaw, Poland Background: Endothelial dysfunction (ED) is involved in the pathogenesis of cerebral small vessel disease (SV...

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Autores principales:	Staszewski J, Piusińska-Macoch R, Brodacki B, Skrobowska E, Stępień A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	cerebral small vessel disease radiological progression IL-6 PF-4 sCD40L homocysteine Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/c2d6a58d2d6c4547b25b88fa8c7d5a03
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spelling	oai:doaj.org-article:c2d6a58d2d6c4547b25b88fa8c7d5a032021-12-02T00:51:08ZIL-6, PF-4, sCD40 L, and homocysteine are associated with the radiological progression of cerebral small-vessel disease: a 2-year follow-up study1178-1998https://doaj.org/article/c2d6a58d2d6c4547b25b88fa8c7d5a032018-06-01T00:00:00Zhttps://www.dovepress.com/il-6-pf-4-scd40-l-and-homocysteine-are-associated-with-the-radiologica-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Jacek Staszewski,1 Renata Piusińska-Macoch,1 Bogdan Brodacki,1 Ewa Skrobowska,2 Adam Stępień1 1Clinic of Neurology, 2Department of Radiology, Military Institute of Medicine, Warsaw, Poland Background: Endothelial dysfunction (ED) is involved in the pathogenesis of cerebral small vessel disease (SVD), however, it is not clear if specific biomarkers related to ED are associated with radiological progression of SVD.Methods: A single-center, prospective cohort study was conducted among consecutive, adult patients with SVD. Logistic regression was used to analyze the association of each baseline biomarker (highest vs lowest tertile) and the MRI radiological outcome after 2 years. The mean Z-score for vascular inflammation (VI) combined soluble intercellular cell adhesion molecule-1 (sICAM-1), soluble platelet selectin (sP-selectin), CD40 ligand (sCD40 L), platelet factor-4 (PF-4) and homocysteine; Z-score for systemic inflammation (SI) combined high-sensitivity C-reactive protein (hsCRP), interleukin-1α and -6 (IL-1α and IL-6, respectively) and tumor necrosis factor-α (TNF-α). Results: The study group comprised 123 patients (age, mean±SD: 72.2±8 years, 49% females), with lacunar stroke (n=49), vascular dementia (n=48), and vascular parkinsonism (n=26). Moreover, 34.9% patients experienced radiological progression, 43% had progression of isolated white matter lesions (WMLs), 23.2% had new lacunes, and 34.8% had both WMLs progression and new lacunes. After adjustment for confounders (age, sex, blood pressure, MRI lesions load), the PF-4 (OR; 95% CI 5.5; 1.5–21), sCD40L (4.6; 1.1–18.6), IL-6 (7.4; 1.48–37), Z-score for VI (4.5; 1.1–18.6), and, marginally, homocysteine (4.1; 0.99–17) were associated with the risk of any radiological progression; further, homocysteine (2.4; 1.4–14), Z-score for SI (2.1; 1.2–14) and, marginally, IL-6 (6.0; 0.95 -38) were related to the development of new lacunes; PF-4 (7.9; 1.6–38) and, marginally, the Z-score for VI (4.2; 0.9–19.5) were correlated with the risk of WMLs progression. Additional adjustment for clinical SVD manifestations did not significantly alter the results. Conclusion: The data supports the concept that ED modulates the radiological progression of SVD and WMLs and lacunes are associated with different inflammatory markers. Keywords: cerebral small-vessel disease, radiological progression, IL-6, PF-4, sCD40 L, homocysteine Staszewski JPiusińska-Macoch RBrodacki BSkrobowska EStępień ADove Medical Pressarticlecerebral small vessel diseaseradiological progressionIL-6PF-4sCD40LhomocysteineGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 1135-1141 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	cerebral small vessel disease radiological progression IL-6 PF-4 sCD40L homocysteine Geriatrics RC952-954.6
spellingShingle	cerebral small vessel disease radiological progression IL-6 PF-4 sCD40L homocysteine Geriatrics RC952-954.6 Staszewski J Piusińska-Macoch R Brodacki B Skrobowska E Stępień A IL-6, PF-4, sCD40 L, and homocysteine are associated with the radiological progression of cerebral small-vessel disease: a 2-year follow-up study
description	Jacek Staszewski,1 Renata Piusińska-Macoch,1 Bogdan Brodacki,1 Ewa Skrobowska,2 Adam Stępień1 1Clinic of Neurology, 2Department of Radiology, Military Institute of Medicine, Warsaw, Poland Background: Endothelial dysfunction (ED) is involved in the pathogenesis of cerebral small vessel disease (SVD), however, it is not clear if specific biomarkers related to ED are associated with radiological progression of SVD.Methods: A single-center, prospective cohort study was conducted among consecutive, adult patients with SVD. Logistic regression was used to analyze the association of each baseline biomarker (highest vs lowest tertile) and the MRI radiological outcome after 2 years. The mean Z-score for vascular inflammation (VI) combined soluble intercellular cell adhesion molecule-1 (sICAM-1), soluble platelet selectin (sP-selectin), CD40 ligand (sCD40 L), platelet factor-4 (PF-4) and homocysteine; Z-score for systemic inflammation (SI) combined high-sensitivity C-reactive protein (hsCRP), interleukin-1α and -6 (IL-1α and IL-6, respectively) and tumor necrosis factor-α (TNF-α). Results: The study group comprised 123 patients (age, mean±SD: 72.2±8 years, 49% females), with lacunar stroke (n=49), vascular dementia (n=48), and vascular parkinsonism (n=26). Moreover, 34.9% patients experienced radiological progression, 43% had progression of isolated white matter lesions (WMLs), 23.2% had new lacunes, and 34.8% had both WMLs progression and new lacunes. After adjustment for confounders (age, sex, blood pressure, MRI lesions load), the PF-4 (OR; 95% CI 5.5; 1.5–21), sCD40L (4.6; 1.1–18.6), IL-6 (7.4; 1.48–37), Z-score for VI (4.5; 1.1–18.6), and, marginally, homocysteine (4.1; 0.99–17) were associated with the risk of any radiological progression; further, homocysteine (2.4; 1.4–14), Z-score for SI (2.1; 1.2–14) and, marginally, IL-6 (6.0; 0.95 -38) were related to the development of new lacunes; PF-4 (7.9; 1.6–38) and, marginally, the Z-score for VI (4.2; 0.9–19.5) were correlated with the risk of WMLs progression. Additional adjustment for clinical SVD manifestations did not significantly alter the results. Conclusion: The data supports the concept that ED modulates the radiological progression of SVD and WMLs and lacunes are associated with different inflammatory markers. Keywords: cerebral small-vessel disease, radiological progression, IL-6, PF-4, sCD40 L, homocysteine
format	article
author	Staszewski J Piusińska-Macoch R Brodacki B Skrobowska E Stępień A
author_facet	Staszewski J Piusińska-Macoch R Brodacki B Skrobowska E Stępień A
author_sort	Staszewski J
title	IL-6, PF-4, sCD40 L, and homocysteine are associated with the radiological progression of cerebral small-vessel disease: a 2-year follow-up study
title_short	IL-6, PF-4, sCD40 L, and homocysteine are associated with the radiological progression of cerebral small-vessel disease: a 2-year follow-up study
title_full	IL-6, PF-4, sCD40 L, and homocysteine are associated with the radiological progression of cerebral small-vessel disease: a 2-year follow-up study
title_fullStr	IL-6, PF-4, sCD40 L, and homocysteine are associated with the radiological progression of cerebral small-vessel disease: a 2-year follow-up study
title_full_unstemmed	IL-6, PF-4, sCD40 L, and homocysteine are associated with the radiological progression of cerebral small-vessel disease: a 2-year follow-up study
title_sort	il-6, pf-4, scd40 l, and homocysteine are associated with the radiological progression of cerebral small-vessel disease: a 2-year follow-up study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/c2d6a58d2d6c4547b25b88fa8c7d5a03
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IL-6, PF-4, sCD40 L, and homocysteine are associated with the radiological progression of cerebral small-vessel disease: a 2-year follow-up study

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