Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology

An actin cap protects the morphology of the nucleus during cellular mechanical stress. Here, the authors show that the nuclear lamina protein lamin A/C mediates the formation of the actin cap in response to stress, and model the distribution of forces in the presence and absence of the actin cap.

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Autores principales:	Jeong-Ki Kim, Arghavan Louhghalam, Geonhui Lee, Benjamin W. Schafer, Denis Wirtz, Dong-Hwee Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c2db46571a9e4e98b6c92809cc4d07ae
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spelling	oai:doaj.org-article:c2db46571a9e4e98b6c92809cc4d07ae2021-12-02T14:40:57ZNuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology10.1038/s41467-017-02217-52041-1723https://doaj.org/article/c2db46571a9e4e98b6c92809cc4d07ae2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02217-5https://doaj.org/toc/2041-1723An actin cap protects the morphology of the nucleus during cellular mechanical stress. Here, the authors show that the nuclear lamina protein lamin A/C mediates the formation of the actin cap in response to stress, and model the distribution of forces in the presence and absence of the actin cap.Jeong-Ki KimArghavan LouhghalamGeonhui LeeBenjamin W. SchaferDenis WirtzDong-Hwee KimNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeong-Ki Kim Arghavan Louhghalam Geonhui Lee Benjamin W. Schafer Denis Wirtz Dong-Hwee Kim Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology
description	An actin cap protects the morphology of the nucleus during cellular mechanical stress. Here, the authors show that the nuclear lamina protein lamin A/C mediates the formation of the actin cap in response to stress, and model the distribution of forces in the presence and absence of the actin cap.
format	article
author	Jeong-Ki Kim Arghavan Louhghalam Geonhui Lee Benjamin W. Schafer Denis Wirtz Dong-Hwee Kim
author_facet	Jeong-Ki Kim Arghavan Louhghalam Geonhui Lee Benjamin W. Schafer Denis Wirtz Dong-Hwee Kim
author_sort	Jeong-Ki Kim
title	Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology
title_short	Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology
title_full	Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology
title_fullStr	Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology
title_full_unstemmed	Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology
title_sort	nuclear lamin a/c harnesses the perinuclear apical actin cables to protect nuclear morphology
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c2db46571a9e4e98b6c92809cc4d07ae
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Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology

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