Global profiling of protein–DNA and protein–nucleosome binding affinities using quantitative mass spectrometry

Quantitative mass spectrometry enables the proteome-wide assessment of biomolecular binding affinities. While previous approaches mainly focused on protein–small molecule interactions, the authors here present a method to probe protein–DNA and protein–nucleosome binding affinities at proteome scale....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Matthew M. Makowski, Cathrin Gräwe, Benjamin M. Foster, Nhuong V. Nguyen, Till Bartke, Michiel Vermeulen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c2e2ac02d50d492280b29ec96a5b844c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c2e2ac02d50d492280b29ec96a5b844c
record_format	dspace
spelling	oai:doaj.org-article:c2e2ac02d50d492280b29ec96a5b844c2021-12-02T16:56:59ZGlobal profiling of protein–DNA and protein–nucleosome binding affinities using quantitative mass spectrometry10.1038/s41467-018-04084-02041-1723https://doaj.org/article/c2e2ac02d50d492280b29ec96a5b844c2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04084-0https://doaj.org/toc/2041-1723Quantitative mass spectrometry enables the proteome-wide assessment of biomolecular binding affinities. While previous approaches mainly focused on protein–small molecule interactions, the authors here present a method to probe protein–DNA and protein–nucleosome binding affinities at proteome scale.Matthew M. MakowskiCathrin GräweBenjamin M. FosterNhuong V. NguyenTill BartkeMichiel VermeulenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew M. Makowski Cathrin Gräwe Benjamin M. Foster Nhuong V. Nguyen Till Bartke Michiel Vermeulen Global profiling of protein–DNA and protein–nucleosome binding affinities using quantitative mass spectrometry
description	Quantitative mass spectrometry enables the proteome-wide assessment of biomolecular binding affinities. While previous approaches mainly focused on protein–small molecule interactions, the authors here present a method to probe protein–DNA and protein–nucleosome binding affinities at proteome scale.
format	article
author	Matthew M. Makowski Cathrin Gräwe Benjamin M. Foster Nhuong V. Nguyen Till Bartke Michiel Vermeulen
author_facet	Matthew M. Makowski Cathrin Gräwe Benjamin M. Foster Nhuong V. Nguyen Till Bartke Michiel Vermeulen
author_sort	Matthew M. Makowski
title	Global profiling of protein–DNA and protein–nucleosome binding affinities using quantitative mass spectrometry
title_short	Global profiling of protein–DNA and protein–nucleosome binding affinities using quantitative mass spectrometry
title_full	Global profiling of protein–DNA and protein–nucleosome binding affinities using quantitative mass spectrometry
title_fullStr	Global profiling of protein–DNA and protein–nucleosome binding affinities using quantitative mass spectrometry
title_full_unstemmed	Global profiling of protein–DNA and protein–nucleosome binding affinities using quantitative mass spectrometry
title_sort	global profiling of protein–dna and protein–nucleosome binding affinities using quantitative mass spectrometry
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c2e2ac02d50d492280b29ec96a5b844c
work_keys_str_mv	AT matthewmmakowski globalprofilingofproteindnaandproteinnucleosomebindingaffinitiesusingquantitativemassspectrometry AT cathringrawe globalprofilingofproteindnaandproteinnucleosomebindingaffinitiesusingquantitativemassspectrometry AT benjaminmfoster globalprofilingofproteindnaandproteinnucleosomebindingaffinitiesusingquantitativemassspectrometry AT nhuongvnguyen globalprofilingofproteindnaandproteinnucleosomebindingaffinitiesusingquantitativemassspectrometry AT tillbartke globalprofilingofproteindnaandproteinnucleosomebindingaffinitiesusingquantitativemassspectrometry AT michielvermeulen globalprofilingofproteindnaandproteinnucleosomebindingaffinitiesusingquantitativemassspectrometry
_version_	1718382704600285184

Global profiling of protein–DNA and protein–nucleosome binding affinities using quantitative mass spectrometry

Ejemplares similares