ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS

Abstract. Autoimmune thyroiditis (Hashimoto’s thyroiditis, HT) still represents an unresolved problem of modern endocrinology, since its etiology and pathogenesis are yet unclear. Cytokines play an important role in the regulation of immune and inflammatory response, therefore, some gene v...

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Autores principales:	E. M. Biktagirova, L. I. Sattarova, G. R. Vagapova, O. A. Kravtsova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	autoimmune thyroiditis gene polymorphism interleukin 1β interleukin 4 interleukin 6 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c2e3d72724624a88b22751fd426cca38
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spelling	oai:doaj.org-article:c2e3d72724624a88b22751fd426cca382021-11-18T08:03:42ZASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS1563-06252313-741X10.15789/1563-0625-2011-6-603-608https://doaj.org/article/c2e3d72724624a88b22751fd426cca382014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/601https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Autoimmune thyroiditis (Hashimoto’s thyroiditis, HT) still represents an unresolved problem of modern endocrinology, since its etiology and pathogenesis are yet unclear. Cytokines play an important role in the regulation of immune and inflammatory response, therefore, some gene variants encoding them, are considered as potential risk risk factors for autoimmune thyroid diseases. We have genotyped 298 women from the Republic of Tatarstan (RT, control group, 137 persons; HT patients, 161) for the following gene polymorphisms: interleukin-1 beta (IL-1β) +3953 C/T (rs 1143634); interleukin 4 (IL-4) -590C/T (rs 2243250), and interleukin 6 (IL-6) -174C/G (rs 1800795), using allele-specific PCR. The results showed a significantly increased frequencies of C allele (P = 0.0003) and CT genotype (P = 0.048, OR = 6.05, 95%CI 2.59-2.97) of +3953 C/T of IL-1β in patients with Hashimoto's thyroiditis, as compared with control group. The latter group showed higher prevalence of T allele (P = 0.0003) and TT genotype (P = 4.95 Ч 6.10; OR = 0.15, 95%CI 0.06-0.38). The 590C/T and -174C/G polymorphic variants in, resp., IL-4 and IL-6 genes are not associated with increased risk of this disease among women from RT. (Med. Immunol., 2011, vol. 13, N 6, pp 603-608)E. M. BiktagirovaL. I. SattarovaG. R. VagapovaO. A. KravtsovaSPb RAACIarticleautoimmune thyroiditisgene polymorphisminterleukin 1βinterleukin 4interleukin 6Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 6, Pp 603-608 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	autoimmune thyroiditis gene polymorphism interleukin 1β interleukin 4 interleukin 6 Immunologic diseases. Allergy RC581-607
spellingShingle	autoimmune thyroiditis gene polymorphism interleukin 1β interleukin 4 interleukin 6 Immunologic diseases. Allergy RC581-607 E. M. Biktagirova L. I. Sattarova G. R. Vagapova O. A. Kravtsova ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS
description	Abstract. Autoimmune thyroiditis (Hashimoto’s thyroiditis, HT) still represents an unresolved problem of modern endocrinology, since its etiology and pathogenesis are yet unclear. Cytokines play an important role in the regulation of immune and inflammatory response, therefore, some gene variants encoding them, are considered as potential risk risk factors for autoimmune thyroid diseases. We have genotyped 298 women from the Republic of Tatarstan (RT, control group, 137 persons; HT patients, 161) for the following gene polymorphisms: interleukin-1 beta (IL-1β) +3953 C/T (rs 1143634); interleukin 4 (IL-4) -590C/T (rs 2243250), and interleukin 6 (IL-6) -174C/G (rs 1800795), using allele-specific PCR. The results showed a significantly increased frequencies of C allele (P = 0.0003) and CT genotype (P = 0.048, OR = 6.05, 95%CI 2.59-2.97) of +3953 C/T of IL-1β in patients with Hashimoto's thyroiditis, as compared with control group. The latter group showed higher prevalence of T allele (P = 0.0003) and TT genotype (P = 4.95 Ч 6.10; OR = 0.15, 95%CI 0.06-0.38). The 590C/T and -174C/G polymorphic variants in, resp., IL-4 and IL-6 genes are not associated with increased risk of this disease among women from RT. (Med. Immunol., 2011, vol. 13, N 6, pp 603-608)
format	article
author	E. M. Biktagirova L. I. Sattarova G. R. Vagapova O. A. Kravtsova
author_facet	E. M. Biktagirova L. I. Sattarova G. R. Vagapova O. A. Kravtsova
author_sort	E. M. Biktagirova
title	ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS
title_short	ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS
title_full	ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS
title_fullStr	ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS
title_full_unstemmed	ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS
title_sort	association of il-1β, il-4 and il-6 genes polymorphisms with genetic predisposition for autoimmune thyroiditis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/c2e3d72724624a88b22751fd426cca38
work_keys_str_mv	AT embiktagirova associationofil1bil4andil6genespolymorphismswithgeneticpredispositionforautoimmunethyroiditis AT lisattarova associationofil1bil4andil6genespolymorphismswithgeneticpredispositionforautoimmunethyroiditis AT grvagapova associationofil1bil4andil6genespolymorphismswithgeneticpredispositionforautoimmunethyroiditis AT oakravtsova associationofil1bil4andil6genespolymorphismswithgeneticpredispositionforautoimmunethyroiditis
_version_	1718422506663051264

ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS

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