Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions

Abstract Exposure to microgravity and ionizing radiation during spaceflight missions causes excessive reactive oxygen species (ROS) production that contributes to cellular stress and damage in astronauts. Average spaceflight mission time is expected to lengthen as humanity aims to visit other planet...

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Autores principales:	Xavier Gómez, Serena Sanon, Kevin Zambrano, Samira Asquel, Mariuxi Bassantes, Julián E. Morales, Gabriela Otáñez, Core Pomaquero, Sarah Villarroel, Alejandro Zurita, Carlos Calvache, Kathlyn Celi, Terry Contreras, Dylan Corrales, María Belén Naciph, José Peña, Andrés Caicedo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biotechnology TP248.13-248.65 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/c2e919d6288d46c781b925b82b76f54b
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spelling	oai:doaj.org-article:c2e919d6288d46c781b925b82b76f54b2021-12-02T17:26:49ZKey points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions10.1038/s41526-021-00162-82373-8065https://doaj.org/article/c2e919d6288d46c781b925b82b76f54b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41526-021-00162-8https://doaj.org/toc/2373-8065Abstract Exposure to microgravity and ionizing radiation during spaceflight missions causes excessive reactive oxygen species (ROS) production that contributes to cellular stress and damage in astronauts. Average spaceflight mission time is expected to lengthen as humanity aims to visit other planets. However, longer missions or spaceflights will undoubtedly lead to an increment in microgravity, ionizing radiation and ROS production. Strategies to minimize ROS damage are necessary to maintain the health of astronauts, future space colonists, and tourists during and after spaceflight missions. An antioxidant cocktail formulated to prevent or mitigate ROS damage during space exploration could help maintain the health of space explorers. We propose key points to consider when developing an antioxidant cocktail. We discuss how ROS damages our body and organs, the genetic predisposition of astronauts to its damage, characteristics and evidence of the effectiveness of antioxidants to combat excess ROS, differences in drug metabolism when on Earth and in space that could modify antioxidant effects, and the characteristics and efficacy of common antioxidants. Based on this information we propose a workflow for assessing astronaut resistance to ROS damage, infight monitoring of ROS production, and an antioxidant cocktail. Developing an antioxidant cocktail represents a big challenge to translate current medical practices from an Earth setting to space. The key points presented in this review could promote the development of different antioxidant formulations to maintain space explorers’ health in the future.Xavier GómezSerena SanonKevin ZambranoSamira AsquelMariuxi BassantesJulián E. MoralesGabriela OtáñezCore PomaqueroSarah VillarroelAlejandro ZuritaCarlos CalvacheKathlyn CeliTerry ContrerasDylan CorralesMaría Belén NaciphJosé PeñaAndrés CaicedoNature PortfolioarticleBiotechnologyTP248.13-248.65PhysiologyQP1-981ENnpj Microgravity, Vol 7, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physiology QP1-981
spellingShingle	Biotechnology TP248.13-248.65 Physiology QP1-981 Xavier Gómez Serena Sanon Kevin Zambrano Samira Asquel Mariuxi Bassantes Julián E. Morales Gabriela Otáñez Core Pomaquero Sarah Villarroel Alejandro Zurita Carlos Calvache Kathlyn Celi Terry Contreras Dylan Corrales María Belén Naciph José Peña Andrés Caicedo Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions
description	Abstract Exposure to microgravity and ionizing radiation during spaceflight missions causes excessive reactive oxygen species (ROS) production that contributes to cellular stress and damage in astronauts. Average spaceflight mission time is expected to lengthen as humanity aims to visit other planets. However, longer missions or spaceflights will undoubtedly lead to an increment in microgravity, ionizing radiation and ROS production. Strategies to minimize ROS damage are necessary to maintain the health of astronauts, future space colonists, and tourists during and after spaceflight missions. An antioxidant cocktail formulated to prevent or mitigate ROS damage during space exploration could help maintain the health of space explorers. We propose key points to consider when developing an antioxidant cocktail. We discuss how ROS damages our body and organs, the genetic predisposition of astronauts to its damage, characteristics and evidence of the effectiveness of antioxidants to combat excess ROS, differences in drug metabolism when on Earth and in space that could modify antioxidant effects, and the characteristics and efficacy of common antioxidants. Based on this information we propose a workflow for assessing astronaut resistance to ROS damage, infight monitoring of ROS production, and an antioxidant cocktail. Developing an antioxidant cocktail represents a big challenge to translate current medical practices from an Earth setting to space. The key points presented in this review could promote the development of different antioxidant formulations to maintain space explorers’ health in the future.
format	article
author	Xavier Gómez Serena Sanon Kevin Zambrano Samira Asquel Mariuxi Bassantes Julián E. Morales Gabriela Otáñez Core Pomaquero Sarah Villarroel Alejandro Zurita Carlos Calvache Kathlyn Celi Terry Contreras Dylan Corrales María Belén Naciph José Peña Andrés Caicedo
author_facet	Xavier Gómez Serena Sanon Kevin Zambrano Samira Asquel Mariuxi Bassantes Julián E. Morales Gabriela Otáñez Core Pomaquero Sarah Villarroel Alejandro Zurita Carlos Calvache Kathlyn Celi Terry Contreras Dylan Corrales María Belén Naciph José Peña Andrés Caicedo
author_sort	Xavier Gómez
title	Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions
title_short	Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions
title_full	Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions
title_fullStr	Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions
title_full_unstemmed	Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions
title_sort	key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ros) during manned space missions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c2e919d6288d46c781b925b82b76f54b
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Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions

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