Assessment of renal function in geriatric palliative care patients – comparison of creatinine-based estimation equations

Assessment of renal function in geriatric palliative care patients – comparison of creatinine-based estimation equations

Ewa Deskur-Smielecka,1,2 Aleksandra Kotlinska-Lemieszek,1,2 Jerzy Chudek,3,4 Katarzyna Wieczorowska-Tobis1,2 1Department of Palliative Medicine, Poznan University of Medical Sciences, 2Palliative Medicine Unit, University Hospital of Lord’s Transfiguration, Poznan, 3Pathophysiology Unit,...

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Autores principales: Deskur-Smielecka E, Kotlinska-Lemieszek A, Chudek J, Wieczorowska-Tobis K
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
glomerular filtration rate
creatinine clearance
palliative care
advanced cancer
the elderly
Geriatrics
RC952-954.6
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spelling oai:doaj.org-article:c2eb9195496d4d95ae75d9f0064698162021-12-02T00:28:26ZAssessment of renal function in geriatric palliative care patients – comparison of creatinine-based estimation equations1178-1998https://doaj.org/article/c2eb9195496d4d95ae75d9f0064698162017-06-01T00:00:00Zhttps://www.dovepress.com/assessment-of-renal-function-in-geriatric-palliative-care-patients-com-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Ewa Deskur-Smielecka,1,2 Aleksandra Kotlinska-Lemieszek,1,2 Jerzy Chudek,3,4 Katarzyna Wieczorowska-Tobis1,2 1Department of Palliative Medicine, Poznan University of Medical Sciences, 2Palliative Medicine Unit, University Hospital of Lord’s Transfiguration, Poznan, 3Pathophysiology Unit, Department of Pathophysiology, 4Department of Internal Medicine and Oncological Chemotherapy, Medical Faculty in Katowice, Medical University of Silesia, Katowice, Poland Background: Renal function impairment is common in geriatric palliative care patients. Accurate assessment of renal function is necessary for appropriate drug dosage. Several equations are used to estimate kidney function. Aims: 1) To investigate the differences (Δ) in kidney function assessed with simplified Modification of Diet in Renal Disease (MDRD), Berlin Initiative Study (BIS1), and Cockcroft–Gault (C-G) formulas in geriatric palliative care patients, and 2) to assess factors that may influence these differences. Methods: A retrospective analysis of data of patients aged ≥70 years admitted to a palliative care in-patient unit. The agreement between C-G, MDRD, and BIS1 equations was assessed with Bland–Altman analysis. Partial correlation analysis was used to analyze factors influencing the discordance. Results: A total of 174 patients (67 men; mean age 77.9±5.8 years) were enrolled. The mean Δ MDRD and C-G was 18.6 (95% limits of agreement 55.3 and -18.2). The mean Δ BIS1 and C-G was 6.1 (25.7 and -13.5), and the mean Δ MDRD and BIS1 was 12.5 (40.6 and -15.6). According to the National Kidney Foundation classification, 61 (35.1%) patients were differently staged using MDRD and C-G, while ~20% of patients were differently staged with BIS1 and C-G and MDRD and BIS1. Serum creatinine (SCr) and body mass index (BMI) had the most important influence on variability of Δ MDRD and C-G (partial R2 37.7% and 28.4%). Variability of Δ BIS1 and C-G was mostly influenced by BMI (34.8%) and variability of Δ MDRD and BIS1 by SCr (42.2%). Age had relatively low influence on differences between equations (3.1%–9.5%). Conclusion: There is a considerable disagreement between renal function estimation formulas, especially MDRD and C-G in geriatric palliative care patients, which may lead to errors in drug dosage adjustment. The magnitude of discrepancy increases with lower SCr, lower BMI, and higher age. Keywords: creatinine clearance, estimated glomerular filtration rate, MDRD, BIS1, Cockcroft-Gault Deskur-Smielecka EKotlinska-Lemieszek AChudek JWieczorowska-Tobis KDove Medical Pressarticleglomerular filtration ratecreatinine clearancepalliative careadvanced cancerthe elderlyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 977-983 (2017)
institution DOAJ
collection DOAJ
language EN
topic glomerular filtration rate
creatinine clearance
palliative care
advanced cancer
the elderly
Geriatrics
RC952-954.6
spellingShingle glomerular filtration rate
creatinine clearance
palliative care
advanced cancer
the elderly
Geriatrics
RC952-954.6
Deskur-Smielecka E
Kotlinska-Lemieszek A
Chudek J
Wieczorowska-Tobis K
Assessment of renal function in geriatric palliative care patients – comparison of creatinine-based estimation equations
description Ewa Deskur-Smielecka,1,2 Aleksandra Kotlinska-Lemieszek,1,2 Jerzy Chudek,3,4 Katarzyna Wieczorowska-Tobis1,2 1Department of Palliative Medicine, Poznan University of Medical Sciences, 2Palliative Medicine Unit, University Hospital of Lord’s Transfiguration, Poznan, 3Pathophysiology Unit, Department of Pathophysiology, 4Department of Internal Medicine and Oncological Chemotherapy, Medical Faculty in Katowice, Medical University of Silesia, Katowice, Poland Background: Renal function impairment is common in geriatric palliative care patients. Accurate assessment of renal function is necessary for appropriate drug dosage. Several equations are used to estimate kidney function. Aims: 1) To investigate the differences (Δ) in kidney function assessed with simplified Modification of Diet in Renal Disease (MDRD), Berlin Initiative Study (BIS1), and Cockcroft–Gault (C-G) formulas in geriatric palliative care patients, and 2) to assess factors that may influence these differences. Methods: A retrospective analysis of data of patients aged ≥70 years admitted to a palliative care in-patient unit. The agreement between C-G, MDRD, and BIS1 equations was assessed with Bland–Altman analysis. Partial correlation analysis was used to analyze factors influencing the discordance. Results: A total of 174 patients (67 men; mean age 77.9±5.8 years) were enrolled. The mean Δ MDRD and C-G was 18.6 (95% limits of agreement 55.3 and -18.2). The mean Δ BIS1 and C-G was 6.1 (25.7 and -13.5), and the mean Δ MDRD and BIS1 was 12.5 (40.6 and -15.6). According to the National Kidney Foundation classification, 61 (35.1%) patients were differently staged using MDRD and C-G, while ~20% of patients were differently staged with BIS1 and C-G and MDRD and BIS1. Serum creatinine (SCr) and body mass index (BMI) had the most important influence on variability of Δ MDRD and C-G (partial R2 37.7% and 28.4%). Variability of Δ BIS1 and C-G was mostly influenced by BMI (34.8%) and variability of Δ MDRD and BIS1 by SCr (42.2%). Age had relatively low influence on differences between equations (3.1%–9.5%). Conclusion: There is a considerable disagreement between renal function estimation formulas, especially MDRD and C-G in geriatric palliative care patients, which may lead to errors in drug dosage adjustment. The magnitude of discrepancy increases with lower SCr, lower BMI, and higher age. Keywords: creatinine clearance, estimated glomerular filtration rate, MDRD, BIS1, Cockcroft-Gault 
format article
author Deskur-Smielecka E
Kotlinska-Lemieszek A
Chudek J
Wieczorowska-Tobis K
author_facet Deskur-Smielecka E
Kotlinska-Lemieszek A
Chudek J
Wieczorowska-Tobis K
author_sort Deskur-Smielecka E
title Assessment of renal function in geriatric palliative care patients – comparison of creatinine-based estimation equations
title_short Assessment of renal function in geriatric palliative care patients – comparison of creatinine-based estimation equations
title_full Assessment of renal function in geriatric palliative care patients – comparison of creatinine-based estimation equations
title_fullStr Assessment of renal function in geriatric palliative care patients – comparison of creatinine-based estimation equations
title_full_unstemmed Assessment of renal function in geriatric palliative care patients – comparison of creatinine-based estimation equations
title_sort assessment of renal function in geriatric palliative care patients – comparison of creatinine-based estimation equations
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/c2eb9195496d4d95ae75d9f006469816
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AT chudekj assessmentofrenalfunctioningeriatricpalliativecarepatientsndashcomparisonofcreatininebasedestimationequations
AT wieczorowskatobisk assessmentofrenalfunctioningeriatricpalliativecarepatientsndashcomparisonofcreatininebasedestimationequations
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