Long-Term Effects of Childhood Cancer Treatment on Dentition and Oral Health: A Dentist Survey Study from the DCCSS LATER 2 Study

Objectives: The aim of this study was to identify the prevalence of and independent risk factors for long-term effects of childhood cancer treatment on the dentition and oral health in childhood cancer survivors (CCSs). Methods: This cross-sectional study is part of the Dutch Childhood Cancer Surviv...

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Autores principales:	Juliette Stolze, Kim C. E. Vlaanderen, Frederique C. E. D. Holtbach, Jop C. Teepen, Leontien C. M. Kremer, Jacqueline J. Loonen, Eline van Dulmen-den Broeder, Marry M. van den Heuvel-Eibrink, Helena J. H. van der Pal, Birgitta Versluys, Margriet van der Heiden-van der Loo, Marloes Louwerens, Judith E. Raber-Durlacher, Dorine Bresters, Henk S. Brand
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	childhood cancer late effects dental developmental disorders dental abnormalities survivors oral health Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/c2ec67a19afe4694926d201b08bc0cc2
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spelling	oai:doaj.org-article:c2ec67a19afe4694926d201b08bc0cc22021-11-11T15:26:40ZLong-Term Effects of Childhood Cancer Treatment on Dentition and Oral Health: A Dentist Survey Study from the DCCSS LATER 2 Study10.3390/cancers132152642072-6694https://doaj.org/article/c2ec67a19afe4694926d201b08bc0cc22021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5264https://doaj.org/toc/2072-6694Objectives: The aim of this study was to identify the prevalence of and independent risk factors for long-term effects of childhood cancer treatment on the dentition and oral health in childhood cancer survivors (CCSs). Methods: This cross-sectional study is part of the Dutch Childhood Cancer Survivor Study (DCCSS) LATER 2. CCSs were diagnosed with cancer between 1963 and 2001. This study focuses on survey data of 154 CCSs on whom information about their oral health was received from their dentists (71.3%). Descriptive statistics and univariable and multivariable Poisson regression analyses were performed to determine the association between treatment characteristics and oral health data. Results: Of the study group, 36.3% had at least one DDD. The most prevalent DDDs were short-root anomaly (14.6%), agenesis (14.3%), and microdontia (13.6%). Risk factors for at least one DDD were younger age at diagnosis (<3 years) and dose-dependent alkylating agent therapy. Conclusions: This study provides more insight into risk factors for oral health problems in Dutch CCSs. This information is essential in order to improve early detection, prevention, dental care, and quality of life. Further studies are needed in order to better define dose-related radiotherapy exposure of the developing teeth in correlation with oral health problems.Juliette StolzeKim C. E. VlaanderenFrederique C. E. D. HoltbachJop C. TeepenLeontien C. M. KremerJacqueline J. LoonenEline van Dulmen-den BroederMarry M. van den Heuvel-EibrinkHelena J. H. van der PalBirgitta VersluysMargriet van der Heiden-van der LooMarloes LouwerensJudith E. Raber-DurlacherDorine BrestersHenk S. BrandMDPI AGarticlechildhood cancerlate effectsdental developmental disordersdental abnormalitiessurvivorsoral healthNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5264, p 5264 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	childhood cancer late effects dental developmental disorders dental abnormalities survivors oral health Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	childhood cancer late effects dental developmental disorders dental abnormalities survivors oral health Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Juliette Stolze Kim C. E. Vlaanderen Frederique C. E. D. Holtbach Jop C. Teepen Leontien C. M. Kremer Jacqueline J. Loonen Eline van Dulmen-den Broeder Marry M. van den Heuvel-Eibrink Helena J. H. van der Pal Birgitta Versluys Margriet van der Heiden-van der Loo Marloes Louwerens Judith E. Raber-Durlacher Dorine Bresters Henk S. Brand Long-Term Effects of Childhood Cancer Treatment on Dentition and Oral Health: A Dentist Survey Study from the DCCSS LATER 2 Study
description	Objectives: The aim of this study was to identify the prevalence of and independent risk factors for long-term effects of childhood cancer treatment on the dentition and oral health in childhood cancer survivors (CCSs). Methods: This cross-sectional study is part of the Dutch Childhood Cancer Survivor Study (DCCSS) LATER 2. CCSs were diagnosed with cancer between 1963 and 2001. This study focuses on survey data of 154 CCSs on whom information about their oral health was received from their dentists (71.3%). Descriptive statistics and univariable and multivariable Poisson regression analyses were performed to determine the association between treatment characteristics and oral health data. Results: Of the study group, 36.3% had at least one DDD. The most prevalent DDDs were short-root anomaly (14.6%), agenesis (14.3%), and microdontia (13.6%). Risk factors for at least one DDD were younger age at diagnosis (<3 years) and dose-dependent alkylating agent therapy. Conclusions: This study provides more insight into risk factors for oral health problems in Dutch CCSs. This information is essential in order to improve early detection, prevention, dental care, and quality of life. Further studies are needed in order to better define dose-related radiotherapy exposure of the developing teeth in correlation with oral health problems.
format	article
author	Juliette Stolze Kim C. E. Vlaanderen Frederique C. E. D. Holtbach Jop C. Teepen Leontien C. M. Kremer Jacqueline J. Loonen Eline van Dulmen-den Broeder Marry M. van den Heuvel-Eibrink Helena J. H. van der Pal Birgitta Versluys Margriet van der Heiden-van der Loo Marloes Louwerens Judith E. Raber-Durlacher Dorine Bresters Henk S. Brand
author_facet	Juliette Stolze Kim C. E. Vlaanderen Frederique C. E. D. Holtbach Jop C. Teepen Leontien C. M. Kremer Jacqueline J. Loonen Eline van Dulmen-den Broeder Marry M. van den Heuvel-Eibrink Helena J. H. van der Pal Birgitta Versluys Margriet van der Heiden-van der Loo Marloes Louwerens Judith E. Raber-Durlacher Dorine Bresters Henk S. Brand
author_sort	Juliette Stolze
title	Long-Term Effects of Childhood Cancer Treatment on Dentition and Oral Health: A Dentist Survey Study from the DCCSS LATER 2 Study
title_short	Long-Term Effects of Childhood Cancer Treatment on Dentition and Oral Health: A Dentist Survey Study from the DCCSS LATER 2 Study
title_full	Long-Term Effects of Childhood Cancer Treatment on Dentition and Oral Health: A Dentist Survey Study from the DCCSS LATER 2 Study
title_fullStr	Long-Term Effects of Childhood Cancer Treatment on Dentition and Oral Health: A Dentist Survey Study from the DCCSS LATER 2 Study
title_full_unstemmed	Long-Term Effects of Childhood Cancer Treatment on Dentition and Oral Health: A Dentist Survey Study from the DCCSS LATER 2 Study
title_sort	long-term effects of childhood cancer treatment on dentition and oral health: a dentist survey study from the dccss later 2 study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c2ec67a19afe4694926d201b08bc0cc2
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Long-Term Effects of Childhood Cancer Treatment on Dentition and Oral Health: A Dentist Survey Study from the DCCSS LATER 2 Study

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