Filovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover.

Bats are reservoirs for several zoonotic pathogens, including filoviruses. Recent work highlights the diversity of bat borne filoviruses in Asia. High risk activities at the bat-human interface pose the threat of zoonotic virus transmission. We present evidence for prior exposure of bat harvesters a...

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Autores principales:	Pilot Dovih, Eric D Laing, Yihui Chen, Dolyce H W Low, B R Ansil, Xinglou Yang, Zhengli Shi, Christopher C Broder, Gavin J D Smith, Martin Linster, Uma Ramakrishnan, Ian H Mendenhall
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2019
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/c2f087dc406748c6a76b954e91540676
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spelling	oai:doaj.org-article:c2f087dc406748c6a76b954e915406762021-12-02T20:23:49ZFilovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover.1935-27271935-273510.1371/journal.pntd.0007733https://doaj.org/article/c2f087dc406748c6a76b954e915406762019-10-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0007733https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Bats are reservoirs for several zoonotic pathogens, including filoviruses. Recent work highlights the diversity of bat borne filoviruses in Asia. High risk activities at the bat-human interface pose the threat of zoonotic virus transmission. We present evidence for prior exposure of bat harvesters and two resident fruit bat species to filovirus surface glycoproteins by screening sera in a multiplexed serological assay. Antibodies reactive to two antigenically distinct filoviruses were detected in human sera and to three individual filoviruses in bats in remote Northeast India. Sera obtained from Eonycteris spelaea bats showed similar patterns of cross-reactivity as human samples, suggesting them as the species responsible for the spillover. In contrast, sera from Rousettus leschenaultii bats reacted to two different virus glycoproteins. Our results indicate circulation of several filoviruses in bats and the possibility for filovirus transmission from bats to humans.Pilot DovihEric D LaingYihui ChenDolyce H W LowB R AnsilXinglou YangZhengli ShiChristopher C BroderGavin J D SmithMartin LinsterUma RamakrishnanIan H MendenhallPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 13, Iss 10, p e0007733 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Pilot Dovih Eric D Laing Yihui Chen Dolyce H W Low B R Ansil Xinglou Yang Zhengli Shi Christopher C Broder Gavin J D Smith Martin Linster Uma Ramakrishnan Ian H Mendenhall Filovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover.
description	Bats are reservoirs for several zoonotic pathogens, including filoviruses. Recent work highlights the diversity of bat borne filoviruses in Asia. High risk activities at the bat-human interface pose the threat of zoonotic virus transmission. We present evidence for prior exposure of bat harvesters and two resident fruit bat species to filovirus surface glycoproteins by screening sera in a multiplexed serological assay. Antibodies reactive to two antigenically distinct filoviruses were detected in human sera and to three individual filoviruses in bats in remote Northeast India. Sera obtained from Eonycteris spelaea bats showed similar patterns of cross-reactivity as human samples, suggesting them as the species responsible for the spillover. In contrast, sera from Rousettus leschenaultii bats reacted to two different virus glycoproteins. Our results indicate circulation of several filoviruses in bats and the possibility for filovirus transmission from bats to humans.
format	article
author	Pilot Dovih Eric D Laing Yihui Chen Dolyce H W Low B R Ansil Xinglou Yang Zhengli Shi Christopher C Broder Gavin J D Smith Martin Linster Uma Ramakrishnan Ian H Mendenhall
author_facet	Pilot Dovih Eric D Laing Yihui Chen Dolyce H W Low B R Ansil Xinglou Yang Zhengli Shi Christopher C Broder Gavin J D Smith Martin Linster Uma Ramakrishnan Ian H Mendenhall
author_sort	Pilot Dovih
title	Filovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover.
title_short	Filovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover.
title_full	Filovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover.
title_fullStr	Filovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover.
title_full_unstemmed	Filovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover.
title_sort	filovirus-reactive antibodies in humans and bats in northeast india imply zoonotic spillover.
publisher	Public Library of Science (PLoS)
publishDate	2019
url	https://doaj.org/article/c2f087dc406748c6a76b954e91540676
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Filovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover.

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