Modeling the distribution of new MRI cortical lesions in multiple sclerosis longitudinal studies.

<h4>Objective</h4>Recent studies have shown the relevance of the cerebral grey matter involvement in multiple sclerosis (MS). The number of new cortical lesions (CLs), detected by specific MRI sequences, has the potential to become a new research outcome in longitudinal MS studies. Aim o...

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Autores principales:	Maria Pia Sormani, Massimiliano Calabrese, Alessio Signori, Antonio Giorgio, Paolo Gallo, Nicola De Stefano
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c2f1f7f648ad45fca5a5e618da9cab10
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spelling	oai:doaj.org-article:c2f1f7f648ad45fca5a5e618da9cab102021-11-18T07:35:59ZModeling the distribution of new MRI cortical lesions in multiple sclerosis longitudinal studies.1932-620310.1371/journal.pone.0026712https://doaj.org/article/c2f1f7f648ad45fca5a5e618da9cab102011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22028937/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Recent studies have shown the relevance of the cerebral grey matter involvement in multiple sclerosis (MS). The number of new cortical lesions (CLs), detected by specific MRI sequences, has the potential to become a new research outcome in longitudinal MS studies. Aim of this study is to define the statistical model better describing the distribution of new CLs developed over 12 and 24 months in patients with relapsing-remitting (RR) MS.<h4>Methods</h4>Four different models were tested (the Poisson, the Negative Binomial, the zero-inflated Poisson and the zero-inflated Negative Binomial) on a group of 191 RRMS patients untreated or treated with 3 different disease modifying therapies. Sample size for clinical trials based on this new outcome measure were estimated by a bootstrap resampling technique.<h4>Results</h4>The zero-inflated Poisson model gave the best fit, according to the Akaike criterion to the observed distribution of new CLs developed over 12 and 24 months both in each treatment group and in the whole RRMS patients group adjusting for treatment effect.<h4>Conclusions</h4>The sample size calculations based on the zero-inflated Poisson model indicate that randomized clinical trials using this new MRI marker as an outcome are feasible.Maria Pia SormaniMassimiliano CalabreseAlessio SignoriAntonio GiorgioPaolo GalloNicola De StefanoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 10, p e26712 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Pia Sormani Massimiliano Calabrese Alessio Signori Antonio Giorgio Paolo Gallo Nicola De Stefano Modeling the distribution of new MRI cortical lesions in multiple sclerosis longitudinal studies.
description	<h4>Objective</h4>Recent studies have shown the relevance of the cerebral grey matter involvement in multiple sclerosis (MS). The number of new cortical lesions (CLs), detected by specific MRI sequences, has the potential to become a new research outcome in longitudinal MS studies. Aim of this study is to define the statistical model better describing the distribution of new CLs developed over 12 and 24 months in patients with relapsing-remitting (RR) MS.<h4>Methods</h4>Four different models were tested (the Poisson, the Negative Binomial, the zero-inflated Poisson and the zero-inflated Negative Binomial) on a group of 191 RRMS patients untreated or treated with 3 different disease modifying therapies. Sample size for clinical trials based on this new outcome measure were estimated by a bootstrap resampling technique.<h4>Results</h4>The zero-inflated Poisson model gave the best fit, according to the Akaike criterion to the observed distribution of new CLs developed over 12 and 24 months both in each treatment group and in the whole RRMS patients group adjusting for treatment effect.<h4>Conclusions</h4>The sample size calculations based on the zero-inflated Poisson model indicate that randomized clinical trials using this new MRI marker as an outcome are feasible.
format	article
author	Maria Pia Sormani Massimiliano Calabrese Alessio Signori Antonio Giorgio Paolo Gallo Nicola De Stefano
author_facet	Maria Pia Sormani Massimiliano Calabrese Alessio Signori Antonio Giorgio Paolo Gallo Nicola De Stefano
author_sort	Maria Pia Sormani
title	Modeling the distribution of new MRI cortical lesions in multiple sclerosis longitudinal studies.
title_short	Modeling the distribution of new MRI cortical lesions in multiple sclerosis longitudinal studies.
title_full	Modeling the distribution of new MRI cortical lesions in multiple sclerosis longitudinal studies.
title_fullStr	Modeling the distribution of new MRI cortical lesions in multiple sclerosis longitudinal studies.
title_full_unstemmed	Modeling the distribution of new MRI cortical lesions in multiple sclerosis longitudinal studies.
title_sort	modeling the distribution of new mri cortical lesions in multiple sclerosis longitudinal studies.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/c2f1f7f648ad45fca5a5e618da9cab10
work_keys_str_mv	AT mariapiasormani modelingthedistributionofnewmricorticallesionsinmultiplesclerosislongitudinalstudies AT massimilianocalabrese modelingthedistributionofnewmricorticallesionsinmultiplesclerosislongitudinalstudies AT alessiosignori modelingthedistributionofnewmricorticallesionsinmultiplesclerosislongitudinalstudies AT antoniogiorgio modelingthedistributionofnewmricorticallesionsinmultiplesclerosislongitudinalstudies AT paologallo modelingthedistributionofnewmricorticallesionsinmultiplesclerosislongitudinalstudies AT nicoladestefano modelingthedistributionofnewmricorticallesionsinmultiplesclerosislongitudinalstudies
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Modeling the distribution of new MRI cortical lesions in multiple sclerosis longitudinal studies.

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