The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
The self-assembly of α-synuclein (αS) is a pathological feature of Parkinson’s disease. The αS species responsible for neuronal damage are not well characterized. Here, the authors show that αS fibrils release soluble prefibrillar oligomeric species responsible for neurotoxicity in vitro.
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/c2f2c92ceab748c787667121d9608d0b |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:c2f2c92ceab748c787667121d9608d0b |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:c2f2c92ceab748c787667121d9608d0b2021-12-02T16:35:53ZThe release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells10.1038/s41467-021-21937-32041-1723https://doaj.org/article/c2f2c92ceab748c787667121d9608d0b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21937-3https://doaj.org/toc/2041-1723The self-assembly of α-synuclein (αS) is a pathological feature of Parkinson’s disease. The αS species responsible for neuronal damage are not well characterized. Here, the authors show that αS fibrils release soluble prefibrillar oligomeric species responsible for neurotoxicity in vitro.Roberta CascellaSerene W. ChenAlessandra BigiJosé D. CaminoCatherine K. XuChristopher M. DobsonFabrizio ChitiNunilo CremadesCristina CecchiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Roberta Cascella Serene W. Chen Alessandra Bigi José D. Camino Catherine K. Xu Christopher M. Dobson Fabrizio Chiti Nunilo Cremades Cristina Cecchi The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells |
| description |
The self-assembly of α-synuclein (αS) is a pathological feature of Parkinson’s disease. The αS species responsible for neuronal damage are not well characterized. Here, the authors show that αS fibrils release soluble prefibrillar oligomeric species responsible for neurotoxicity in vitro. |
| format |
article |
| author |
Roberta Cascella Serene W. Chen Alessandra Bigi José D. Camino Catherine K. Xu Christopher M. Dobson Fabrizio Chiti Nunilo Cremades Cristina Cecchi |
| author_facet |
Roberta Cascella Serene W. Chen Alessandra Bigi José D. Camino Catherine K. Xu Christopher M. Dobson Fabrizio Chiti Nunilo Cremades Cristina Cecchi |
| author_sort |
Roberta Cascella |
| title |
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells |
| title_short |
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells |
| title_full |
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells |
| title_fullStr |
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells |
| title_full_unstemmed |
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells |
| title_sort |
release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c2f2c92ceab748c787667121d9608d0b |
| work_keys_str_mv |
AT robertacascella thereleaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells AT serenewchen thereleaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells AT alessandrabigi thereleaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells AT josedcamino thereleaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells AT catherinekxu thereleaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells AT christophermdobson thereleaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells AT fabriziochiti thereleaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells AT nunilocremades thereleaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells AT cristinacecchi thereleaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells AT robertacascella releaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells AT serenewchen releaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells AT alessandrabigi releaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells AT josedcamino releaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells AT catherinekxu releaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells AT christophermdobson releaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells AT fabriziochiti releaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells AT nunilocremades releaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells AT cristinacecchi releaseoftoxicoligomersfromasynucleinfibrilsinducesdysfunctioninneuronalcells |
| _version_ |
1718383716719394816 |