A novel, multitargeted endogenous metabolic modulator composition impacts metabolism, inflammation, and fibrosis in nonalcoholic steatohepatitis-relevant primary human cell models

Abstract Nonalcoholic steatohepatitis (NASH) is a complex metabolic disease of heterogeneous and multifactorial pathogenesis that may benefit from coordinated multitargeted interventions. Endogenous metabolic modulators (EMMs) encompass a broad set of molecular families, including amino acids and re...

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Autores principales: Nadine Daou, Andreu Viader, Murat Cokol, Arianna Nitzel, Manu V. Chakravarthy, Raffi Afeyan, Tony Tramontin, Svetlana Marukian, Michael J. Hamill
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c2f374aab92a482f9c189e152af4110d
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