Tetraspanins: Host Factors in Viral Infections

Tetraspanins are transmembrane glycoproteins that have been shown increasing interest as host factors in infectious diseases. In particular, they were implicated in the pathogenesis of both non-enveloped (human papillomavirus (HPV)) and enveloped (human immunodeficiency virus (HIV), Zika, influenza...

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Autores principales:	ChihSheng New, Zhao-Yong Lee, Kai Sen Tan, Amanda Huee-Ping Wong, De Yun Wang, Thai Tran
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	CD9 CD63 CD151 CD81 coronavirus COVID-19 Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c2f4a5bd74094ee88e3bef53a92c9681
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id	oai:doaj.org-article:c2f4a5bd74094ee88e3bef53a92c9681
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spelling	oai:doaj.org-article:c2f4a5bd74094ee88e3bef53a92c96812021-11-11T17:05:12ZTetraspanins: Host Factors in Viral Infections10.3390/ijms2221116091422-00671661-6596https://doaj.org/article/c2f4a5bd74094ee88e3bef53a92c96812021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11609https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Tetraspanins are transmembrane glycoproteins that have been shown increasing interest as host factors in infectious diseases. In particular, they were implicated in the pathogenesis of both non-enveloped (human papillomavirus (HPV)) and enveloped (human immunodeficiency virus (HIV), Zika, influenza A virus, (IAV), and coronavirus) viruses through multiple stages of infection, from the initial cell membrane attachment to the syncytium formation and viral particle release. However, the mechanisms by which different tetraspanins mediate their effects vary. This review aimed to compare and contrast the role of tetraspanins in the life cycles of HPV, HIV, Zika, IAV, and coronavirus viruses, which cause the most significant health and economic burdens to society. In doing so, a better understanding of the relative contribution of tetraspanins in virus infection will allow for a more targeted approach in the treatment of these diseases.ChihSheng NewZhao-Yong LeeKai Sen TanAmanda Huee-Ping WongDe Yun WangThai TranMDPI AGarticleCD9CD63CD151CD81coronavirusCOVID-19Biology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11609, p 11609 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CD9 CD63 CD151 CD81 coronavirus COVID-19 Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	CD9 CD63 CD151 CD81 coronavirus COVID-19 Biology (General) QH301-705.5 Chemistry QD1-999 ChihSheng New Zhao-Yong Lee Kai Sen Tan Amanda Huee-Ping Wong De Yun Wang Thai Tran Tetraspanins: Host Factors in Viral Infections
description	Tetraspanins are transmembrane glycoproteins that have been shown increasing interest as host factors in infectious diseases. In particular, they were implicated in the pathogenesis of both non-enveloped (human papillomavirus (HPV)) and enveloped (human immunodeficiency virus (HIV), Zika, influenza A virus, (IAV), and coronavirus) viruses through multiple stages of infection, from the initial cell membrane attachment to the syncytium formation and viral particle release. However, the mechanisms by which different tetraspanins mediate their effects vary. This review aimed to compare and contrast the role of tetraspanins in the life cycles of HPV, HIV, Zika, IAV, and coronavirus viruses, which cause the most significant health and economic burdens to society. In doing so, a better understanding of the relative contribution of tetraspanins in virus infection will allow for a more targeted approach in the treatment of these diseases.
format	article
author	ChihSheng New Zhao-Yong Lee Kai Sen Tan Amanda Huee-Ping Wong De Yun Wang Thai Tran
author_facet	ChihSheng New Zhao-Yong Lee Kai Sen Tan Amanda Huee-Ping Wong De Yun Wang Thai Tran
author_sort	ChihSheng New
title	Tetraspanins: Host Factors in Viral Infections
title_short	Tetraspanins: Host Factors in Viral Infections
title_full	Tetraspanins: Host Factors in Viral Infections
title_fullStr	Tetraspanins: Host Factors in Viral Infections
title_full_unstemmed	Tetraspanins: Host Factors in Viral Infections
title_sort	tetraspanins: host factors in viral infections
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c2f4a5bd74094ee88e3bef53a92c9681
work_keys_str_mv	AT chihshengnew tetraspaninshostfactorsinviralinfections AT zhaoyonglee tetraspaninshostfactorsinviralinfections AT kaisentan tetraspaninshostfactorsinviralinfections AT amandahueepingwong tetraspaninshostfactorsinviralinfections AT deyunwang tetraspaninshostfactorsinviralinfections AT thaitran tetraspaninshostfactorsinviralinfections
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Tetraspanins: Host Factors in Viral Infections

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