Exosome-mediated stable epigenetic repression of HIV-1

A strategy to control HIV-1 infection is to stably repress HIV-1 and induce “deep latency”. Here the authors show that a recombinant anti-HIV-1-1 protein can be packaged as mRNA into exosomes and delivered systemically to repress HIV-1-1 within the context of virus infected mice and achieve long ter...

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Autores principales:	Surya Shrivastava, Roslyn M. Ray, Leo Holguin, Lilliana Echavarria, Nicole Grepo, Tristan A. Scott, John Burnett, Kevin V. Morris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c2f5bfdbc83d4fcc98387b48cc1d19d1
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spelling	oai:doaj.org-article:c2f5bfdbc83d4fcc98387b48cc1d19d12021-12-02T18:48:11ZExosome-mediated stable epigenetic repression of HIV-110.1038/s41467-021-25839-22041-1723https://doaj.org/article/c2f5bfdbc83d4fcc98387b48cc1d19d12021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25839-2https://doaj.org/toc/2041-1723A strategy to control HIV-1 infection is to stably repress HIV-1 and induce “deep latency”. Here the authors show that a recombinant anti-HIV-1-1 protein can be packaged as mRNA into exosomes and delivered systemically to repress HIV-1-1 within the context of virus infected mice and achieve long term silencing of HIV-1-1 expression.Surya ShrivastavaRoslyn M. RayLeo HolguinLilliana EchavarriaNicole GrepoTristan A. ScottJohn BurnettKevin V. MorrisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Surya Shrivastava Roslyn M. Ray Leo Holguin Lilliana Echavarria Nicole Grepo Tristan A. Scott John Burnett Kevin V. Morris Exosome-mediated stable epigenetic repression of HIV-1
description	A strategy to control HIV-1 infection is to stably repress HIV-1 and induce “deep latency”. Here the authors show that a recombinant anti-HIV-1-1 protein can be packaged as mRNA into exosomes and delivered systemically to repress HIV-1-1 within the context of virus infected mice and achieve long term silencing of HIV-1-1 expression.
format	article
author	Surya Shrivastava Roslyn M. Ray Leo Holguin Lilliana Echavarria Nicole Grepo Tristan A. Scott John Burnett Kevin V. Morris
author_facet	Surya Shrivastava Roslyn M. Ray Leo Holguin Lilliana Echavarria Nicole Grepo Tristan A. Scott John Burnett Kevin V. Morris
author_sort	Surya Shrivastava
title	Exosome-mediated stable epigenetic repression of HIV-1
title_short	Exosome-mediated stable epigenetic repression of HIV-1
title_full	Exosome-mediated stable epigenetic repression of HIV-1
title_fullStr	Exosome-mediated stable epigenetic repression of HIV-1
title_full_unstemmed	Exosome-mediated stable epigenetic repression of HIV-1
title_sort	exosome-mediated stable epigenetic repression of hiv-1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c2f5bfdbc83d4fcc98387b48cc1d19d1
work_keys_str_mv	AT suryashrivastava exosomemediatedstableepigeneticrepressionofhiv1 AT roslynmray exosomemediatedstableepigeneticrepressionofhiv1 AT leoholguin exosomemediatedstableepigeneticrepressionofhiv1 AT lillianaechavarria exosomemediatedstableepigeneticrepressionofhiv1 AT nicolegrepo exosomemediatedstableepigeneticrepressionofhiv1 AT tristanascott exosomemediatedstableepigeneticrepressionofhiv1 AT johnburnett exosomemediatedstableepigeneticrepressionofhiv1 AT kevinvmorris exosomemediatedstableepigeneticrepressionofhiv1
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Exosome-mediated stable epigenetic repression of HIV-1

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