Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach

Taccalonolide microtubule stabilizers covalently bind β-tubulin and overcome taxane resistance mechanisms. Here, the authors synthesized fluorogenic taccalonolide probes and investigated the specificity of taccalonolide binding to β-tubulin and the molecular interactions between drug and target,

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Autores principales:	Lin Du, Samantha S. Yee, Karthik Ramachandran, April L. Risinger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c2f5d7e5ec534b638cfd953643d55b03
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spelling	oai:doaj.org-article:c2f5d7e5ec534b638cfd953643d55b032021-12-02T17:31:57ZElucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach10.1038/s41467-019-14277-w2041-1723https://doaj.org/article/c2f5d7e5ec534b638cfd953643d55b032020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14277-whttps://doaj.org/toc/2041-1723Taccalonolide microtubule stabilizers covalently bind β-tubulin and overcome taxane resistance mechanisms. Here, the authors synthesized fluorogenic taccalonolide probes and investigated the specificity of taccalonolide binding to β-tubulin and the molecular interactions between drug and target,Lin DuSamantha S. YeeKarthik RamachandranApril L. RisingerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lin Du Samantha S. Yee Karthik Ramachandran April L. Risinger Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach
description	Taccalonolide microtubule stabilizers covalently bind β-tubulin and overcome taxane resistance mechanisms. Here, the authors synthesized fluorogenic taccalonolide probes and investigated the specificity of taccalonolide binding to β-tubulin and the molecular interactions between drug and target,
format	article
author	Lin Du Samantha S. Yee Karthik Ramachandran April L. Risinger
author_facet	Lin Du Samantha S. Yee Karthik Ramachandran April L. Risinger
author_sort	Lin Du
title	Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach
title_short	Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach
title_full	Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach
title_fullStr	Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach
title_full_unstemmed	Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach
title_sort	elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c2f5d7e5ec534b638cfd953643d55b03
work_keys_str_mv	AT lindu elucidatingtargetspecificityofthetaccalonolidecovalentmicrotubulestabilizersemployingacombinatorialchemicalapproach AT samanthasyee elucidatingtargetspecificityofthetaccalonolidecovalentmicrotubulestabilizersemployingacombinatorialchemicalapproach AT karthikramachandran elucidatingtargetspecificityofthetaccalonolidecovalentmicrotubulestabilizersemployingacombinatorialchemicalapproach AT aprillrisinger elucidatingtargetspecificityofthetaccalonolidecovalentmicrotubulestabilizersemployingacombinatorialchemicalapproach
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Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach

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