Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach
Taccalonolide microtubule stabilizers covalently bind β-tubulin and overcome taxane resistance mechanisms. Here, the authors synthesized fluorogenic taccalonolide probes and investigated the specificity of taccalonolide binding to β-tubulin and the molecular interactions between drug and target,
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2020
|
| Subjects: | |
| Online Access: | https://doaj.org/article/c2f5d7e5ec534b638cfd953643d55b03 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|